Antioxidant properties of aminoguanidine

Courderot-Masuyer, Carol; Dalloz, Florence; Maupoil, Véronique; Rochette, Luc

doi:10.1111/j.1472-8206.1999.tb00358.x

Cited by 63 publications

(38 citation statements)

References 24 publications

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“…AG has been reported to be an effective hydroxyl radical scavenger. 37 AG exhibits a significant dose-dependent effect against free radical damage. Aminoguanidine has been shown to exhibit trapping activity toward lipid-derived aldehydes such as MDA and 4-hydroxynonenal.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide‐induced hemorrhagic cystitis in rat

Abraham

Rabi

Selvakumar

2008

Cell Biochemistry & Function

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Cyclophosphamide (CP) is an antineoplastic agent that is used for the treatment of many neoplastic diseases. Hemorrhagic cystitis (HC) is a major dose limiting side effect of CP. Recent studies show that aminogaunidine, an inhibitor of inducible nitric oxide synthase is a potent antioxidant and prevents changes caused by oxidative stress such as depletion of antioxidant activity and tissue injury. The purpose of the study is to investigate the effect of aminoguanidine on parameters of oxidative stress, antioxidant enzymes and bladder injury caused by CP. Adult male rats were randomly divided into four groups. Control rats were administered saline; the AG control group received 200 mg/kg body wt of aminoguanidine; The CP group received a single injection of CP at the dose of 150 mg/kg body wt intraperitoneally. The CP þAG group received aminoguanidine (200 mg/kg body wt) intraperitoneally 1 h before the administration of CP. The rats were sacrificed 16 h after CP/saline administration. The bladder was used for light microscopic studies and biochemical studies. The markers of oxidative damage including protein carbonyl content, protein thiol, malondialdehyde and conjugated dienes were assayed in the homogenates along with the activities of the antioxidant enzymes, superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase and glutathione S transferase. In the bladders of CP treated rats edema of lamina propria with epithelial and sub-epithelial hemorrhage was seen. All the parameters of oxidative stress that were studied were significantly elevated in the bladders of CP treated rats. The activities of the antioxidant enzymes were significantly lowered in the bladders of CP treated rats. Aminoguanidine pretreatment prevented CP-induced oxidative stress, decrease in the activities of anti-oxidant enzymes and reduced bladder damage. The results of the present study suggest the antioxidant role for aminoguanidine in CP-induced bladder damage.

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Section: Discussionmentioning

confidence: 99%

Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide‐induced hemorrhagic cystitis in rat

Abraham

Rabi

Selvakumar

2008

Cell Biochemistry & Function

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“…According to the methods of Courderot-Masuyer et al ( 14 ), the reaction mixture containing 37.5 n M allophycocyanin, 3 m M AAPH, and aqueous solution of test sample in 75 m M phosphate buffer (pH 7.0) was incubated at 37˚C. The fluorescence obtained just before the addition of the radical generator AAPH was used as the 100% value for that sample.…”

Section: Methodsmentioning

confidence: 99%

Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes

Lee

Cho

Tanaka

et al. 2007

J Nutr Sci Vitaminol

160

105

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SummaryThe present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC 50 values of 4.35 and 2.41 g/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2 ′ -azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetesrelated pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against ␣ -amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of ␣ -amylase activity would probably depend on the degree of polymerization. On the other hand, against ␣ -glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems.

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“…10 In addition to being an inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. [11][12][13] It was reported that induction of iNOS after I/R increased peroxynitrite formation, has harmful effects on various tissues.…”

Section: Introductionmentioning

confidence: 99%

Effects of aminoguanidine against renal ischaemia–reperfusion injury in rats

Şahna

Parlakpınar

Cihan

et al. 2006

Cell Biochem. Funct.

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Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). In addition to being an inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that aminoguanidine reduces ischaemia-reperfusion (I/R)-induced damage. However, the role of aminoguanidine, in renal injury associated with I/R remains unknown. This study was designed to investigate the effects of aminoguanidine on renal I/R injury. There were three groups of eight rats each. I/R was induced by occlusion of the left renal vessels for 60 min, followed by 24 h reperfusion in rats. Malondialdehyde (MDA) levels, a stable metabolite of the free radical-mediated lipid peroxidation cascade, were found to be significantly higher in the I/R group (30.3 +/- 0.1 nmol g(-1) tissue) than in the control group (10 +/- 0.05 nmol g(-1)). Aminoguanidine (100 mg kg(-1)) administration to rats significantly reduced the MDA values. We also demonstrated that I/R leads to structural change but aminoguanidine did not reverse this change. Aminoguanidine, according to the biochemical finding is protective but histopathological findings did not reveal protection against I/R injury in kidney. The effects of aminoguanidine on I/R-induced damage remain a subject for future investigations.

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Antioxidant properties of aminoguanidine

Cited by 63 publications

References 24 publications

Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide‐induced hemorrhagic cystitis in rat

Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide‐induced hemorrhagic cystitis in rat

Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes

Effects of aminoguanidine against renal ischaemia–reperfusion injury in rats

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