Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Repetto, Marisa G.; Llesuy, Susana

doi:10.1590/s0100-879x2002000500003

Cited by 432 publications

(309 citation statements)

References 38 publications

Supporting

Mentioning

277

Contrasting

Unclassified

Order By: Relevance

“…One of the main mechanisms attributed to the toxic effect of ethanol is the alteration in gastric cell homeostasis and tissue damage resulting from its direct action on the mucosa and the formation of free radicals and reactive oxygen species (19,20) .…”

Section: Discussionmentioning

confidence: 99%

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Nesello

Campos

Rosa

et al. 2017

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. Objective -The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. Methods -The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm 2 ) and relative lesion area (%) were determined. Results -The results showed significant gastroprotective activity against the aggressive agents used -ethanol and indomethacin -for all the extracts tested. Conclusion -It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Nesello

Campos

Rosa

et al. 2017

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Because of the side effects from the use of synthetic compounds (Yildirim et al, 2001), the search for natural substances that can be used as antioxidants in the food, cosmetic and health industries has been intensified (Repetto and Llesuy, 2002). In plants, these compounds are mainly represented by polyphenols, such as flavonoids, and carotenoids (Lizcano et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and phenol content of extracts of bark, stems, and young and mature leaves from Blepharocalyx salicifolius (Kunth) O. Berg

et al. 2016

View full text Add to dashboard Cite

Phenolic compounds are a group of plant secondary metabolites known to have a variety of bioactivities, including the ability to function as antioxidants. Because of the side effects of the use of synthetic substances, the search for natural and less toxic compounds has increased significantly. This study was designed to evaluate the antioxidant activity and phenol content of hexane, ethyl acetate, and aqueous extracts of the bark (suber) and stems as well as the young and mature leaves of Blepharocalyx salicifolius. The extracts were obtained by extraction with organic solvents and subsequent fractionation by chromatographic partition coefficient. Preliminary tests for the presence of antioxidants were performed using bioautography in thin-layer chromatography. The antioxidant activity of the extracts was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and the phenol content of the extracts was quantified using the Folin-Ciocalteu technique. The results showed that 9 of the 12 extracts evaluated displayed very strong antioxidant activity and three displayed moderate activity. Aqueous extracts of the young leaves and bark and the ethyl acetate extract of the young leaves showed the highest levels of antioxidant activity and total phenolic content (TPC). A correlation was observed between TPC and antioxidant activity index (AAI) with a correlation coefficient (r 2 ) of 0.7999. Thus, the high phenol content of B. salicifolius extracts and its correlation with antioxidant activity provide substrates for further studies.Keywords: bioactivity, Brazilian Savana (Cerrado), leaf maturation stage, Myrtaceae, scavenging free radicals.Atividade antioxidante e teor de polifenóis de extratos de cascas (súber), caule, folhas jovens e folhas maduras de Blepharocalyx salicifolius (Kunth) O. Berg (Murta) ResumoOs polifenóis são um grupo de metabólitos secundários vegetais que possuem uma variedade de bioatividades conhecidas, dentre elas a capacidade de funcionar como antioxidantes. Devido aos efeitos colaterais do uso excessivo de substâncias sintéticas, a busca por compostos naturais e menos tóxicos têm aumentado significativamente. Esse estudo teve por objetivo avaliar a atividade antioxidante e o teor de polifenóis dos extratos hexânicos, acetato de etila e aquosos de cascas (súber), caules, folhas jovens e folhas maduras de Blepharocalyx salicifolius. Os extratos foram obtidos por meio de extração com solventes orgânicos e subsequente fracionamento em cromatografia por coeficiente de partição. Testes preliminares da presença de compostos com atividade antioxidante foram realizados por meio de bioautografia em cromatografia de camada delgada. Os extratos foram submetidos ao teste da capacidade sequestrante do radical 2,2-difenil-1-picrilhidrazil (DPPH) para quantificação da atividade antioxidante e submetidos ao teste com o reagente de Folin-Ciocalteu para quantificação dos polifenóis. Os resultados mostraram que dos 12 extratos avaliados, 9 apresentaram atividade antioxidante muito forte e 3 atividad...

show abstract

“…Kvietys et al (1990) observed the involvement of neutrophils on the inflammatory process induced by ethanol, that attack the gastric mucosa and this releases inflammatory mediators that are responsible by recruitment of neutrophils. The oxidative stress is also involved on the pathogenesis caused by ethanol, hence the generation of free radicals causes cell and tissue damages, resulting on the gastric lesions (Repetto & Llesuy, 2002).…”

Section: Resultsmentioning

confidence: 99%

Biological activity of Herissantia crispa (L.) Brizicky

Lima¹,

Costa²,

Matias³

et al. 2009

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Atividade biológica da Herissantia crispa (L.) Brizicky". O extrato metanólico bruto (EMeOH) das partes aéreas da Herissantia crispa (L.) Brizicky, planta rica em flavonóides e que não possui estudos farmacológicos, foi testada para avaliar sua atividade sob os parâmetros comportamentais e determinar a dose letal 50 (DL 50 ) em camundongos; atividade antimicrobiana e antiulcerogênica. O EMeOH (5000 mg/kg, v.o. ou 2000 mg/kg i.p.) não alterou os parâmetros comportamentais e não causou mortes nos animais. A amostra vegetal em estudo inibiu o crescimento bacteriano. O EMeOH (750 mg/kg) apresentou atividade anti-diarréica. O EMeOH (250, 500 e 750 mg/kg) foi capaz de inibir as lesões gástricas induzidas pelo 0,3 M HCl/etanol 60% em camundongos. Desta forma, pode-se concluir que a planta em estudo apresenta atividade antiulcerogênica, entretanto, se faz necessário avaliar tal atividade através de modelos mais específicos e estudar o mecanismo de ação pelo qual a amostra vegetal protege a mucosa gástrica.Unitermos: Herissantia crispa, Malvaecae, avaliação comportamental, atividade antibacteriana, atividade antiulcerogênica. ABSTRACT:The crude methanol extract (EMeOH) of the aerial parts of Herissantia crispa (L.) Brizicky, plant riches in flavonoids and without pharmacological studies, was tested to value its activity under the behaviour parameters and to determine the lethal dose (LD 50 ) in mice; antimicrobial and antiulcerogenic activities. The EMeOH (5,000 mg/kg, v.o. or 2,000 mg/kg i.p.) did not alter the behaviour parameters and there were not mice deaths. The extract inhibited the bacterial growth. The EMeOH (750 mg/kg) showed anti-diarroeal activity. The EMeOH (250, 500 and 750 mg/kg) decreased the gastric lesions induced by 0.3 M HCl/ethanol 60% in mice. In conclusion, the EMeOH presents anti-ulcerogenic activity;, however it is necessary to value the antiulcerogenic activity in more specific models and to study the action mechanism by which the vegetable sample protects the gastric mucosa.

show abstract

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers

Cited by 432 publications

References 38 publications

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Screening of Wild Fruit Trees With Gastroprotective Activity in Different Experimental Models

Antioxidant activity and phenol content of extracts of bark, stems, and young and mature leaves from Blepharocalyx salicifolius (Kunth) O. Berg

Biological activity of Herissantia crispa (L.) Brizicky

Contact Info

Product

Resources

About