Antioxidant Properties of Nigella sativa

Alenzi, Faris Q.; Altamimi, Mohammed A Alsakran; Kujan, Omar; Tarakji, Bassel; Tamimi, Waleed; Bagader, Omar; Al-Shangiti, Ali; Talohi, Abdulrahman N.; Alenezy, Awwad; Alswailmi, Farhan Khashim; Alenizi, Dhaifallah; Salem, Mohamed L.; Wyse, Richard K.H.

doi:10.4172/1747-0862.1000077

Cited by 26 publications

(14 citation statements)

References 58 publications

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“…Nigella sativa oil acts as an anti‐oxidant (Meral, Yener, Kahraman, & Mert, ), as well as a source of calcium, iron, sodium and potassium; these are essential co‐factors in various enzyme functions that improve sperm cryosurvivability. Flavonoids, anthocyanins, carotene, isothiocyanates and carotenoids are antioxidant components of N. sativa which can contribute to antioxidant defence and scavenge ROS (Alenzi et al, ). Yeste et al () stated that reduced glutathione improved boar sperm cryosurvival and fertilizing ability when added to freezing extenders.…”

Section: Discussionmentioning

confidence: 99%

Effects of pre‐freezeNigella sativaoil supplementation on cryosurvival of ovine spermatozoa

Miah

Bathgate

Hamano

et al. 2018

Reprod Domestic Animals

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Contents The study was designed with three experiments to evaluate the effects of pre‐freeze supplementation of Nigella sativa oil (NSO) and thymoquinone (TQ) on total motility, progressive motility, biokinetic characteristics, acrosomal integrity and DNA integrity of cryopreserved ovine spermatozoa. Semen samples collected from three proven fertile Merino rams were diluted with a Tris‐based cryomedia containing different levels of NSO (Experiment I: 0, 10, 100 and 1,000 g/ml), TQ (Experiment II: 0, 1, 10 and 20 g/ml) and their optimum levels (Experiment III: 100 g/ml of NSO, 10 g/ml of TQ and 1 mM of α‐tocopherol and cryopreserved as pellet (200µL) and subsequently evaluated at different post‐thaw incubation periods (0, 2 and 4 hr). The results revealed that the percentage of total motility, progressive motility and biokinetic characteristics such as average path velocity, curvilinear velocity and straight‐line velocity were higher (p < 0.05) in the sperm aliquots cryopreserved with 100 g/ml NSO or 10 g/ml TQ than in the sperm aliquots cryopreserved without supplementation just after thawing and 2 hr of post‐thaw incubation. Among the supplements, NSO (100 g/ml) showed higher values of the total motility, progressive motility, biokinetic characteristics specially, average path velocity, curvilinear velocity and straight‐line velocity, acrosome integrity and DNA integrity compared with the spermatozoa frozen without supplementation. Therefore, the results suggest that NSO may be added to the cryomedium to improve the cryosurvival of ovine spermatozoa.

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Section: Discussionmentioning

confidence: 99%

Effects of pre‐freezeNigella sativaoil supplementation on cryosurvival of ovine spermatozoa

Miah

Bathgate

Hamano

et al. 2018

Reprod Domestic Animals

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“…Early prognosis indicates that the disruption of angiogenic function in cancer cell is thought to be selective, affecting only the cancer cells, but not the normal cell [28,29]. This predicted selective effect of TQ was based on study showing toxicity in normal cells at the minimal level [30].…”

Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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“…Nigella sativa L. (Black seed) possesses therapeutic properties such as antioxidative (Alenzi et al, 2013), immunomodulatory, anti-inflammatory (Majdalawieh and Fayyad 2015), neuroprotective (Islam et al, 2015), genoprotective (Al-shdefat et al,2014) Previously published studies have shown that Nigella sativa (N. sativa) oil (NSO) has been reported to have anti-inflammatory, antioxidant and immunomodulatory, anti-carcinogenic, anti-hypertensive, and anti-ischemic properties (Majdalawieh and Fayyad 2015).Nigella. Sativa is recognized because of its role in improving the reproductive performance of male rats (Al-Sa'aidi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil

Sanaa

Nahas

2020

Egyptian Academic Journal of Biological Sciences, F. Toxicology

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Bispyribac sodium is commonly used as a herbicide worldwide. Few studies had investigated the health impact of exposure to it. Redox homeostasis has a great role during organogenesis through in cell growth, differentiation, and death. The aim of this study is to investigate the redox homeostasis imbalance and teratogenic effect of BPS in female rats exposed to bispyribac sodium (BPS) during organogenesis and evaluates the protective role of Nigella Sativa Oil (NSO). Pregnant female rats were grouped into four groups, negative and positive (NSO) control groups. While the others, BPS with and without NSO treatment groups. Results showed that BPS exposure during the pregnancy led to maternal and fetotoxicity as evidenced by preimplantation, post-implantation loss, reduction in placenta weight, reduction in fetal weight, fetal length, skeletal anomalies (incomplete ossification, misaligned sternbrae), visceral malformation (anophthalmia, microphthalmia, internal hydrocephaly, and microcephaly) and oxidative stress in dams serum. NSO treatment exhibited amelioration in the aforementioned maternal and fetotoxicity against BPS exposure.

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Antioxidant Properties of Nigella sativa

Cited by 26 publications

References 58 publications

Effects of pre‐freezeNigella sativaoil supplementation on cryosurvival of ovine spermatozoa

Effects of pre‐freezeNigella sativaoil supplementation on cryosurvival of ovine spermatozoa

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil

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