Antioxidant properties of thiamine

Lukienko, P. I.; Melnichenko, N.G.; Zverinskii, I. V.; Zabrodskaya, S. V.

doi:10.1007/bf02682257

Cited by 124 publications

(93 citation statements)

References 5 publications

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“…In vitro and in vivo studies indicate that thiamine [48] and benfotiamine [29] have antioxidant properties, notwithstanding the report that benfotiamine has no effect on ROS accumulation induced by high glucose [30], which is in keeping with results obtained by us using human endothelial cells (P. Madeddu, unpublished observations). In addition, we found that benfotiamine supplementation did not restore the reduced GSH:GSSG ratio in diabetic mice.…”

Section: Discussionsupporting

confidence: 86%

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis

et al. 2006

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Aims/hypothesis: Benfotiamine, a vitamin B1 analogue, reportedly prevents diabetic microangiopathy. The aim of this study was to evaluate whether benfotiamine is of benefit in reparative neovascularisation using a type I diabetes model of hindlimb ischaemia. We also investigated the involvement of protein kinase B (PKB)/Akt in the therapeutic effects of benfotiamine. Methods: Streptozotocin-induced diabetic mice, given oral benfotiamine or vehicle, were subjected to unilateral limb ischaemia. Reparative neovascularisation was analysed by histology. The expression of Nos3 and Casp3 was evaluated by real-time PCR, and the activation state of PKB/Akt was assessed by western blot analysis and immunohistochemistry. The functional importance of PKB/Akt in benfotiamine-induced effects was investigated using a dominant-negative construct.

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Section: Discussionsupporting

confidence: 86%

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis

et al. 2006

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“…Similarly, oxidative stress is associated with region-specific neuronal death, and lipid peroxidation product accumulates in the remaining thalamic neurons after 11 days inTD animal models [116]. In vitro,thiamine inhibits lipid peroxidation and the free radical oxidation of oleic acid in rat liver microsomes [117]. Male Wistar rats were intoxicated with an ethanol dose; the MDA, reduction GSH and vitamin E values were used as parameters of the liver's antioxidant system and showed improvement for the thiamine-treated group [118].…”

Section: Oxidative Stressmentioning

confidence: 99%

The Role of Thiamine in Autism

Lương¹

2013

AJPN

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Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed.

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“…In this respect, vitamin B1 plays a major role and its deficiency is lethal during the early part of gestation [57]. This vitamin affords some protection to the early embryo both because it prevents an extensive use of electrons for ROS production after releasing the feedback of ATP on its synthesis [58] and because it traps ROS efficiently [59].…”

Section: Ros Formation In the Mitochondria Of Placental And Fetal Tismentioning

confidence: 99%

“…These findings underline that we need to learn more on the mechanisms of vitamin action and dual potential. Conflicting observations are obtained on the role of vitamin B1 deficiency in gestation failure: secretion of pituitary hormones or estrogen do not seem to be impaired despite a loss of appetite in gestating rats [57], while this vitamin can be recruited and activated in cells of the pituitary or blood vessel walls scavenging damaged cell components after an episode of ischemia [105] and is also an efficient ROS trapping component [59]. Increased rates of ROS fluxes have been reported in vitamin A, B2, B6, B9 or B12 deficiencies [60,94,[106][107][108] which, together with the ROS trapping ability of these compounds [21,60,61,69,70,109,110], points to some relationship to ROS phenomena, in addition to their effect on the control of gene expression and metabolism [29,65,67,68,[110][111][112].…”

Section: Defense Against Ros and The Outcome Of Gestationmentioning

confidence: 99%

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

2006

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-In mammals, radical oxygen species (ROS) are essential factors of cell replication, differentiation and growth (oxidative signal), notably during gestation, but are also potentially damaging agents. In Women, ROS play a role in remodeling of uterine tissues, implantation of the embryo, settlement of the villi and development of blood vessels characteristic of gestation. The body stores of vitamins and minerals of gestating females are used to keep ROS fluxes at a level corresponding to oxidative signals and to prevent an imbalance between their production and scavenging (oxidative stress), which would be detrimental to the mother and fetus. There is some evidence that, although based on different regulatory mechanisms, most of the effects of ROS reported in humans also occur in pregnant ruminant females, some of which have been actually reported. Many vitamins and trace elements have dual effects in the organism of mammals: (a) they are involved in the control of metabolic pathways or/and gene expression, (b) but most of the time they also display ROS trapping activity or their deficiencies induce high rates of ROS production. Deficiencies induce different disorders of gestation and can be induced by different kinds of stress. An example is given, corresponding to the decreased contents of cobalt of forages, when exposed to sustained heavy rains, so that the supply of vitamins B12 to the organism of the ruminant that grazes them is reduced and failure of gestation is induced. Outdoor exposure of ruminants to adverse climatic conditions by itself can increase the vitamin and trace element requirements. Adaptation of production systems taking into account these interactions between gestation and sources of stress or change of the quality of feeding stuffs as well as further developments of knowledge in that field is necessary to promote sustainable agricultural practices.gestation / ovine / bovine / vitamins / trace elements / antioxidant enzymes / radical oxygen species / radical phenomena

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Antioxidant properties of thiamine

Cited by 124 publications

References 5 publications

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis

The Role of Thiamine in Autism

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

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