Antioxidant-rich beetroot juice does not adversely affect acute neuromuscular adaptation following eccentric exercise

Clifford, Tom; Bell, Oliver; West, Daniel J.; Howatson, Glyn; Stevenson, Emma

doi:10.1080/02640414.2016.1192670

Cited by 18 publications

(16 citation statements)

References 43 publications

(45 reference statements)

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“…Regarding this, our LLLT-induced oxidative stress inhibition findings may fall into the debate whether antioxidant treatment could attenuate or eliminate exercise-induced adaptive response in skeletal muscle [ 47 ]. Although some researchers have not reported ablation of beneficial exercise role with an antioxidant treatment [ 48 ], it was demonstrated that giving antioxidant (e.g., vitamin C) the whole adaptive response was knocked out [ 49 ]. Consequently, the impact of the LLLT-induced oxidative stress prevention in important physiological process as exercise-induced adaptation (e.g., muscle hypertrophy) shows to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High‐Intensity Resistive Exercise

Oliveira

Antônio

Arsa

et al. 2018

Oxidative Medicine and Cellular Longevity

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The aim of this study was to determine whether oxidative stress markers are influenced by low-intensity laser therapy (LLLT) in rats subjected to a high-intensity resistive exercise session (RE). Female Wistar rats divided into three experimental groups (Ctr: control, 4J: LLLT, and RE) and subdivided based on the sampling times (instantly or 24 h postexercise) underwent irradiation with LLLT using three-point transcutaneous method on the hind legs, which was applied to the gastrocnemius muscle at the distal, medial, and proximal points. Laser (4J) or placebo (device off) were carried out 60 sec prior to RE that consisted of four climbs bearing the maximum load with a 2 min time interval between each climb. Lipoperoxidation levels and antioxidant capacity were obtained in muscle. Lipoperoxidation levels were increased (4-HNE and CL markers) instantly post-RE. LLLT prior to RE avoided the increase of the lipid peroxidation levels. Similar results were also notified for oxidation protein assays. The GPx and FRAP activities did not reduce instantly or 24 h after RE. SOD increased 24 h after RE, while CAT activity did not change with RE or LLLT. In conclusion, LLLT prior to RE reduced the oxidative stress markers, as well as, avoided reduction, and still increased the antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%

Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High‐Intensity Resistive Exercise

Oliveira

Antônio

Arsa

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…It was demonstrated that giving antioxidant vitamin C or C and E complex reduced PGC-1 a or NRF2 activation and the whole adaptive response was knocked out ([20], [21], [35], [38], [40], [53], [61] (Table 1.)). However, other investigators noted that the adaptive response is much more complex and regulated by multi protein pathways and signaling agents besides ROS, and also that antioxidant treatment did not eliminate the beneficial effects of exercise [13], [25], [28], [55], [58], [64].…”

Section: Introductionmentioning

confidence: 99%

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

et al. 2017

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It is debated whether exercise-induced ROS production is obligatory to cause adaptive response. It is also claimed that antioxidant treatment could eliminate the adaptive response, which appears to be systemic and reportedly reduces the incidence of a wide range of diseases. Here we suggest that if the antioxidant treatment occurs before the physiological function-ROS dose-response curve reaches peak level, the antioxidants can attenuate function. On the other hand, if the antioxidant treatment takes place after the summit of the bell-shaped dose response curve, antioxidant treatment would have beneficial effects on function. We suggest that the effects of antioxidant treatment are dependent on the intensity of exercise, since the adaptive response, which is multi pathway dependent, is strongly influenced by exercise intensity. It is further suggested that levels of ROS concentration are associated with peak physiological function and can be extended by physical fitness level and this could be the basis for exercise pre-conditioning. Physical inactivity, aging or pathological disorders increase the sensitivity to oxidative stress by altering the bell-shaped dose response curve.

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“…Adding beetroot juice to the food of rats along with paracetamol results in decrease AST and ALT significantly to normal levels in rats. On the other hand, in human taking beetroot juice following a marathon decreased AST serum levels but not significantly compared to a placebo 31,47 . Beetroot mechanisms of action are through its anti-oxidant and anti-inflammatory properties and by enhances energy production via nitrate 24 .…”

Section: Fig 8a and B: Electromicrographs Of Rat Liver Of Group IV Smentioning

confidence: 82%

Untitled

2020

IJPSR

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Hepatotoxicity in the form of acute liver failure is a serious side effect of several drugs most importantly paracetamol. Beetroot main ingredients are nitrate, betalains, phenolics and ascorbic acid, which are responsible for its protective against oxidative stress and inflammation. Aim: This study assessed the possible protective effect of beetroot against liver toxicity induced by paracetamol. Method: Forty adult male rats where divided into four groups (ten/each): control groups, group I and II (with and without beetroot juice), group III, paracetamol treated group (400 mg/kg/day), and group IV protected group (paracetamol concomitant with beetroot juice by gavage 2 ml/day) for one month. Blood samples and liver tissues were collected and subjected to biochemical and microscopic analysis, respectively. Results: Results demonstrated that paracetamol consumption, group III, induced toxicity to the liver evident by high ALT and AST. The intake of beetroot juice concomitantly with paracetamol (group IV) ameliorates its side effects supported by histological findings and liver function chemistry results. Group IV showed a decreased ALT and AST levels to normal levels. Liver tissue and cells appeared close to normal under light and transmission electron microscope. In conclusion, results suggest a complementary effect of beetroot to mediate anti-hepatotoxicity.

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Antioxidant-rich beetroot juice does not adversely affect acute neuromuscular adaptation following eccentric exercise

Cited by 18 publications

References 43 publications

Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High‐Intensity Resistive Exercise

Photobiomodulation Leads to Reduced Oxidative Stress in Rats Submitted to High‐Intensity Resistive Exercise

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

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