Antioxidant Rich Tropical Herbs to Combat Areca-Nut Induced Opmds

Illeperuma, Rasika P.; Bandara, Kasun; Kim, Do Kyeong; Siriwardena, B. S. M. S.; Jayasinghe, Ruwan Duminda; Kim, Jin; Tilakaratne, Wanninayake Mudiyanselage

doi:10.1016/j.oooo.2019.02.203

Cited by 2 publications

(1 citation statement)

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“…One of the important findings related to alleviation of arecanut toxicity is co-administration antioxidants. Investigations by Illeperuma et al have shown that antioxidant rich herbal extracts can prevent arecanut induced ROS generation and genotoxicity in immortalized human oral keratinocytes and DNA double strand breaks in a mouse model [ 81 ]. Investigations by Zhou et al have shown that vitamins C and E can alleviate hepatoxic effects of arecanut in mice [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study

Paranagama

Piyarathne

Nandasena

et al. 2020

BMC Complement Med Ther

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Background The Sri Lankan traditional betel quid (TBQ) which had been extensively used in the country before its colonization is claimed to have antiperiodontopathic effects in the Sri Lankan folklore. However, there is no reported scientific evidence to support the claimed antiperiodontopathic effects mediated by this TBQ. The present study was carried out to investigate the protective effect of the Sri Lankan TBQ in the pathogenesis of periodontitis. Methods We investigate the ethyl acetate extract of the Sri Lankan TBQ for its antibacterial effects against the keystone periodontopathic bacterium, P. gingivalis and also its antioxidant potential, which is important to protect the periodontium from oxidative stress. Further, its safety was analyzed using the cytokinesis block micronucleus assay on human peripheral blood lymphocytes (PBLs). Results Ethyl acetate extract of this TBQ inhibited the growth of P. gingivalis with a minimum bactericidal concentration (MBC) of 125 μg/ml. It was found to be a rich source of polyphenols and displayed considerable DPPH and ABTS radical scavenging activities and a strong ferric reducing antioxidant power. This extract could protect the cultured human gingival fibroblasts from H 2 O 2 induced oxidative stress. In addition, this TBQ extract was not genotoxic to human PBLs even at a concentration of 2.5 mg/ml. Moreover, it exhibited protective effects against bleomycin induced genotoxicity in PBLs. Conclusion Ethyl acetate extract of the Sri Lankan TBQ is a source of natural antibacterial compounds against P. gingivalis . It is also a source of natural antioxidants which can protect human gingival fibroblasts from H 2 O 2 induced oxidative stress. These properties of the TBQ may have contributed to its claimed antiperiodontopathic effects. Besides, it was found to be relatively non-toxic to human cells. Thus this TBQ extract has a huge potential to be developed as a novel adjunctive therapeutic lead against periodontitis.

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Section: Discussionmentioning

confidence: 99%