Antioxidant secondary metabolites from<i>Geranium lasiopus</i>Boiss. &amp; Heldr.

Şöhretoğlu, Didem; Sakar, M. Koray; Sabuncuoğlu, Suna; Özgüneş, Hilâl; Duman, Hayrí; Sterner, Olov

doi:10.1080/14786419.2011.578071

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…Their relative integral established a ratio of 0.4 : 1.0 for 1 and 2 , respectively. Compounds 1 and 2 were confirmed after the complete interpretation of the NMR data and the comparison with data reported in the literature regarding 1 and 2 . In the Tables S1 and S2, one could find a detailed comparison of previously reported data with the data described herein.…”

Section: Resultssupporting

confidence: 70%

Flavonoid glycosides from Persea caerulea. Unraveling their interactions with SDS‐micelles through matrix‐assisted DOSY, PGSE, mass spectrometry, and NOESY

Álvarez

Raya-Barón

Nieto

et al. 2016

Magnetic Reson in Chemistry

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Two flavonoid glycosides derived from rhamnopyranoside (1) and arabinofuranoside (2) have been isolated from leaves of Persea caerulea for the first time. The structures of 1 and 2 have been established by H NMR, C NMR, and IR spectroscopy, together with LC-ESI-TOF and LC-ESI-IT MS spectrometry. From the MS and MS/MS data, the molecular weights of the intact molecules as well as those of quercetin and kaempferol together with their sugar moieties were deduced. The NMR data provided information on the identity of the compounds, as well as the α and β configurations and the position of the glycosides on quercetin and kaempferol. We have also explored the application of sodium dodecyl sulfate (SDS) normal micelles in binary aqueous solution, at a range of concentrations, to the diffusion resolution of these two glycosides, by the application of matrix-assisted diffusion ordered spectroscopy (DOSY) and pulse field gradient spin echo (PGSE) methodologies, showing that SDS micelles offer a significant resolution which can, in part, be rationalized in terms of differing degrees of hydrophobicity, amphiphilicity, and steric effects. In addition, intra-residue and inter-residue proton-proton distances using nuclear Overhauser effect build-up curves were used to elucidate the conformational preferences of these two flavonoid glycosides when interacting with the micelles. By the combination of both diffusion and nuclear Overhauser spectroscopy techniques, the average location site of kaempferol and quercetin glycosides has been postulated, with the former exhibiting a clear insertion into the interior of the SDS-micelle, whereas the latter is placed closer to the surface. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultssupporting

confidence: 70%

Flavonoid glycosides from Persea caerulea. Unraveling their interactions with SDS‐micelles through matrix‐assisted DOSY, PGSE, mass spectrometry, and NOESY

Álvarez

Raya-Barón

Nieto

et al. 2016

Magnetic Reson in Chemistry

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“…The genus, Geranium , which belongs to the Geraniaceae family, is represented by 350 species in the world, of which 38 species include 14 endemic taxons in Turkey [ 83 ]. The genus Geranium is known to contain flavonoids, tannins, anthocyanidins, lignans, sterols, and polyphenolic compounds, as well as essential oils [ 84 ]. Geraniaceae are herbs or subshrubs, and a family of flowering plants in the order Geraniales.…”

Section: Polyphenols and Plant Familiesmentioning

confidence: 99%

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Riyaphan¹,

Pham

Leong

et al. 2021

Biomolecules

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Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose with surplus adverse effects, leading to efforts devoted to urgently seeking new anti-diabetes drugs from natural sources for delayed starch digestion. This review attempts to explore 10 families e.g., Bignoniaceae, Ericaceae, Dryopteridaceae, Campanulaceae, Geraniaceae, Euphorbiaceae, Rubiaceae, Acanthaceae, Rutaceae, and Moraceae as medicinal plants, and folk and herb medicines for lowering blood glucose level, or alternative anti-diabetic natural products. Many natural products have been studied in silico, in vitro, and in vivo assays to restrain hyperglycemia. In addition, natural products, and particularly polyphenols, possess diverse structures for exploring them as inhibitors of α-glucosidase and α-amylase. Interestingly, an in silico discovery approach using natural compounds via virtual screening could directly target α-glucosidase and α-amylase enzymes through Monte Carto molecular modeling. Autodock, MOE-Dock, Biovia Discovery Studio, PyMOL, and Accelrys have been used to discover new candidates as inhibitors or activators. While docking score, binding energy (Kcal/mol), the number of hydrogen bonds, or interactions with critical amino acid residues have been taken into concerning the reliability of software for validation of enzymatic analysis, in vitro cell assay and in vivo animal tests are required to obtain leads, hits, and candidates in drug discovery and development.

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“…19 To date there is no pharmacological effects described for compounds 3 and 4 but, compound 3 showed different antioxidant activities 20 and compound 4 is a tyrosinase inhibitor. …”

Section: Resultsmentioning

confidence: 99%

Flavonoids and other bioactive phenolics isolated from Cenostigma macrophyllum (Leguminosae)

Alves¹,

David²,

David³

et al. 2012

Quím. Nova

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Recebido em 1/9/11; aceito em 6/12/11; publicado na web em 31/1/12This work describes the phytochemical study of stem bark and leaves of Cenostigma macrophyllum Tul. (Leguminosae). Through usual chromatographic techniques were isolated bergenin as the primary compound of the stem bark of and from the leaves gallic acid, methyl gallate, ellagic acid, quercetin, quercetin, agathisflavone and vitexin were obtained. The isolates were identified by spectroscopic data analysis, and bergenin showed dose-related antinociception when assessed in acetic acid-induced writhing in mice.

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Antioxidant secondary metabolites fromGeranium lasiopusBoiss. & Heldr.

Cited by 9 publications

References 7 publications

Flavonoid glycosides from Persea caerulea. Unraveling their interactions with SDS‐micelles through matrix‐assisted DOSY, PGSE, mass spectrometry, and NOESY

Flavonoid glycosides from Persea caerulea. Unraveling their interactions with SDS‐micelles through matrix‐assisted DOSY, PGSE, mass spectrometry, and NOESY

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

Flavonoids and other bioactive phenolics isolated from Cenostigma macrophyllum (Leguminosae)

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