Antioxidant status in patients with bladder cancer regarding cancer stage and grade

Lepara, Zahid; Alić, Jasmin; Lepara, Orhan; Spahović, H.; Fajkić, Almir

doi:10.1016/j.ajur.2021.12.008

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…However, no significant differences were observed in the MDA level between the T1 and T2-T4 groups [49]. In contrast to our results, the more invasive stages of bladder cancer with greater progression potential (T2-T4) were related to increased enzyme antioxidant activity and decreased non-enzymatic antioxidant capacity [50]. In some cases, especially in the early stages, cancer cells could adapt to intrinsic oxidative stress or drug-induced oxidative stress by increasing their antioxidant system [51].…”

Section: Discussioncontrasting

confidence: 99%

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

et al. 2023

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Oxidative stress is defined as an imbalanced state of the production of reactive oxygen species and antioxidant capacity that causes oxidative damage to biomolecules, leading to cell injury and finally death. Oxidative stress mediates the development and progression of several cancer diseases, including bladder cancer. The aim of our study was to determine markers of levels of the oxidative stress in serum and urine in the same patients in parallel in serum and urine. Furthermore, we tried to estimate the associations between oxidative stress markers and the type of cancer, its clinical stage and grade, as the well as correlations between serum and urinary markers in patients with bladder cancer. Sixty-one bladder cancer and 50 healthy volunteers as a control group were included. We determined the serum and urine levels of advanced oxidation protein products (AOPP), Amadori products, total antioxidant capacity, total oxidant status (TOS), oxidative status index (OSI), and malondialdehyde. We confirm that almost all markers are elevated in serum and urine from patients with bladder cancer than from healthy subjects. Moreover, we did not find differences in the level of oxidative stress markers and the type of tumor, its clinical stage, and grade. We noted correlations between serum and urinary biomarkers, in particular TOS and OSI. Our results clearly indicate the participation of oxidative stress in the development of bladder cancer.

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Section: Discussioncontrasting

confidence: 99%

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

et al. 2023

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“…более инвазивные стадии злокачественных новообразований с большим потенциалом прогрессирования связаны с увеличением фермен-тативной антиоксидантной активности и снижением неферментативной антиоксидантной способности [12,13,14]. повышенные уровни афК вызывают экспрессию антиоксидантных ферментов, таких как каталаза и супероксиддисмутаза, которые защищают клетки против окислительного стресса.…”

Section: Discussionunclassified

Changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process

Alkhusein-Kulyaginova,

Dodokhova,

Vlasova

et al. 2023

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Objective: to evaluate changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process.Materials and methods: the study was conducted on mice of the C57Bl/6 line (females). 48 hours after the transplantation of tumor cells to female mice of the C57Bl/6 line, the studied compounds were administered intraperitoneally 1 time per day for 5 days according to the classical method used for screening compounds with a suspected antitumor effect. The tested compounds were administered at a total dose of 375 mg/kg. The animals were removed from the experiment on the 7th and 18th days after the transplantation of tumor cells.Results: with the introduction of Me-3, there was a decrease in malondialdehyde as the main indicator of the activity of lipid peroxidation at all stages of the development of the tumor process.Conclusions: the multidirectional effect of Me-3 on the enzymatic activity of the antioxidant system on days 7 and 18 of the development of melanoma B16 suggests some selectivity of action depending on the initial pro/antioxidant status of the cell, as well as the expediency of studying this group of compounds as a substrate for nanozymes with pro/antioxidant activity.

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“…In fact, the authors observed an increased risk of NMIBC following vitamin E administration, suggesting that its supplementation may be harmful to these patients [ 76 ]. In another clinical trial involving a cross-sectional study in which 90 BCa patients were recruited, significantly increased activities of antioxidant enzymes such as superoxide dismutase and catalase were associated with more invasive stages of BCa and with a higher progression potential [ 77 ]. This further suggests that antioxidants may have a dual role in BCa development and progression, and therefore, further investigations are required to provide a comprehensive understanding of the biology of antioxidants in the development and progression of BCa as well as other cancer types.…”

Section: Utilizing Oxidative Stress-based Strategies In the Treatment...mentioning

confidence: 99%

Redox System and Oxidative Stress-Targeted Therapeutic Approaches in Bladder Cancer

Dugbartey,

Relouw,

McFarlane

et al. 2024

Antioxidants

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Bladder cancer (BCa) is the most common genitourinary malignancy, with a high global incidence and recurrence rate that is paired with an increasing caregiver burden and higher financial cost, in addition to increasing morbidity and mortality worldwide. Histologically, BCa is categorized into non-muscle invasive, muscle invasive, and metastatic BCa, on the basis of which the therapeutic strategy is determined. Despite all innovations and recent advances in BCa research, conventional therapies such as chemotherapy, immunotherapy, radiotherapy, and surgery fall short in the complete management of this important malignancy. Besides this worrying trend, the molecular basis of BCa development also remains poorly understood. Burgeoning evidence from experimental and clinical studies suggests that oxidative stress resulting from an imbalance between reactive oxygen species (ROS) generation and the body’s antioxidant production plays an integral role in BCa development and progression. Hence, ROS-induced oxidative stress-related pathways are currently under investigation as potential therapeutic targets of BCa. This review focuses on our current understanding regarding ROS-associated pathways in BCa pathogenesis and progression, as well as on antioxidants as potential adjuvants to conventional BCa therapy.

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Antioxidant status in patients with bladder cancer regarding cancer stage and grade

Cited by 3 publications

References 19 publications

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

Oxidative Stress Markers in Urine and Serum of Patients with Bladder Cancer

Changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process

Redox System and Oxidative Stress-Targeted Therapeutic Approaches in Bladder Cancer

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