Antioxidant Studies of Thiazole Ring Bearing Chalcone Derivatives

Abstract

Oxidative stress is one of the common problems seen in a variety of diseases. Chalcones and in particular heteroaryl chalcones had reported with promising antioxidant activities. Hence, in the present work, we reported the antioxidant activity of twenty thiazole ring bearing chalcone derivatives (1-20). Among the tested compounds, compounds 17, 19 and 20 containing 2-pyridinyl, 3-pyridinyl and 2-thiazolyl scaffolds showed superior antioxidant activity than the standard with their IC50 values 4±1µg/mL, 3±1 µg/mL and 5±1 µg/mL respectively. The compound 19 is an interesting lead for the development of newer antioxidant agents.

Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review

“…The World Health Organization (WHO) reported that about a third of the world’s population is infected with M. tuberculosis . Kasetti and co-workers reported bioactive compounds containing thiazole and chalcone pharmacophores . All synthesized compounds were evaluated for their antitubercular activities by MTT assays.…”

“…A series of anticancer active thiazole-based chalcone derivatives 43 were reported by Kasetti and co-workers . Here, thiazole-carbaldehyde 41 was synthesized in three steps.…”

“…Kasetti and co-workers reported antioxidant active thiazole-based chalcone derivatives through the common Claisen–Schmidt condensation reaction . Here, thiazole-carbaldehyde 34 was dissolved in glacial acetic acid and hydrochloric acid.…”

“…Kasetti and co-workers reported antioxidant active thiazole-based chalcone derivatives through the common Claisen–Schmidt condensation reaction. 31 Here, thiazole-carbaldehyde 34 was dissolved in glacial acetic acid and hydrochloric acid. To this mixture was added aryl or heteroaryl ketone moiety 35 , which was previously dissolved in ethanol, and the mixture was refluxed.…”

“…A series of anticancer active thiazole-based chalcone derivatives 43 were reported by Kasetti and co-workers. 31 Here, thiazole-carbaldehyde 41 was synthesized in three steps. First, thiazole-carboxylate 39 was formed through subjecting benzamide 37 to 2-chloroacetate 38 .…”