Antioxidant supplementation and atrial arrhythmias in critically ill trauma patients

Mirhoseini, Mina F.; Hamblin, Susan; Moore, Will; Pouliot, Jonathon D.; Jenkins, Judith M.; Wang, Wei; Chandrasekhar, Rameela; Collier, Bryan R.; Patel, Mayur B.

doi:10.1016/j.jss.2017.09.012

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…There is still a lack of proper studies covering isolated use of Se in treatment of AF. Mirhoseini et al analyzed data from 4699 critically ill patients admitted to the intensive care unit [ 111 ]. The group, which received a mix of antioxidants (i.e., vitamin C, vitamin E and Se), did not display better outcomes in terms of incidence reduction in atrial arrhythmias compared to controls in the first two weeks of hospitalization (3.02% vs. 3.31%, p = 0.62).…”

Section: The Application Of Se In the Prevention And Treatment Of Cvdmentioning

confidence: 99%

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Leszto,

Biskup,

Korona

et al. 2024

Antioxidants

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Cardiovascular diseases stand as the predominant global cause of mortality, exerting a profound impact on both life expectancy and its quality. Given their immense public health burden, extensive efforts have been dedicated to comprehending the underlying mechanisms and developing strategies for prevention and treatment. Selenium, a crucial participant in redox reactions, emerges as a notable factor in maintaining myocardial cell homeostasis and influencing the progression of cardiovascular disorders. Some disorders, such as Keshan disease, are directly linked with its environmental deficiency. Nevertheless, the precise extent of its impact on the cardiovascular system remains unclear, marked by contradictory findings in the existing literature. High selenium levels have been associated with an increased risk of developing hypertension, while lower concentrations have been linked to heart failure and atrial fibrillation. Although some trials have shown its potential effectiveness in specific groups of patients, large cohort supplementation attempts have generally yielded unsatisfactory outcomes. Consequently, there persists a significant need for further research aimed at delineating specific patient cohorts and groups of diseases that would benefit from selenium supplementation.

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Section: The Application Of Se In the Prevention And Treatment Of Cvdmentioning

confidence: 99%

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Leszto,

Biskup,

Korona

et al. 2024

Antioxidants

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“…It is worth paying more attention to antioxidants before planned cardioversion, or in patients with implanted cardiac resynchronisation therapy defibrillators (CRT-D) or ICDs, in order to increase treatment effectiveness. Currently, there is a significant amount of research into the use of antioxidants in AF; however, the results are inconclusive [ 38 , 39 , 40 , 41 , 42 ]. There are at least several pathophysiological mechanisms, and each of them requires further research.…”

Section: Antioxidants In Arrhythmia Treatmentmentioning

confidence: 99%

“…Antioxidants can reduce OS in inflammation or cardiac ischaemia after surgery, which is one of the POAF development mechanisms. Mirhoseini et al presented antioxidant supplementation and atrial arrhythmias in critically ill trauma patients, representing a very diverse group [ 41 ]. AF is the most common arrhythmia and is independently associated with higher mortality in trauma patients [ 43 ].…”

Section: Antioxidants In Arrhythmia Treatmentmentioning

confidence: 99%

“…One of the studies used a high dose of an antioxidant (vitamin C—1000 mg orally, per tube or intravenously every 8 h, vitamin E—1000 units orally or per tube every 8 h and selenium—200 mcg orally, per tube or intravenously, daily for 7 days in total) during a two-week hospitalisation or before discharge, and showed the differences between the antioxidant and control groups. No differences were found in the hospital mortality rates, but the use of antioxidants was associated with a longer expected survival time [ 41 ]. Antioxidants may have antiarrhythmic effects, but they also reduce the inflammatory reaction severity, an important arrhythmogenic factor often found in injuries and polytrauma.…”

Section: Antioxidants In Arrhythmia Treatmentmentioning

confidence: 99%

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Antioxidants in Arrhythmia Treatment—Still a Controversy? A Review of Selected Clinical and Laboratory Research

Szyller

Jagielski²,

Bil‐Lula

2022

Antioxidants

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Antioxidants are substances that can prevent damage to cells caused by free radicals. Production of reactive oxygen species and the presence of oxidative stress play an important role in cardiac arrhythmias. Currently used antiarrhythmic drugs have many side effects. The research on animals and humans using antioxidants (such as vitamins C and E, resveratrol and synthetic substances) yields many interesting but inconclusive results. Natural antioxidants, such as vitamins C and E, can reduce the recurrence of atrial fibrillation (AF) after successful electrical cardioversion and protect against AF after cardiac surgery, but do not affect the incidence of atrial arrhythmias in critically ill patients with trauma. Vitamins C and E may also effectively treat ventricular tachycardia, ventricular fibrillation and long QT-related arrhythmias. Another natural antioxidant—resveratrol—may effectively treat AF and ventricular arrhythmias caused by ischaemia–reperfusion injury. It reduces the mortality associated with life-threatening ventricular arrhythmias and can be used to prevent myocardial remodelling. Statins also show antioxidant activity. Their action is related to the reduction of oxidative stress and anti-inflammatory effect. Therefore, statins can reduce the post-operative risk of AF and may be useful in lowering its recurrence rate after successful cardioversion. Promising results also apply to polyphenols, nitric oxide synthase inhibitors and MitoTEMPO. Although few clinical trials have been conducted, the use of antioxidants in treating arrhythmias is an interesting prospect.

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Cardiac Arrhythmias in Trauma Patients Undergoing Pericardiotomy: A Retrospective Analysis

Chae,

D'Ambrosio,

Kulshrestha

et al. 2024

Journal of Surgical Research

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Antioxidant supplementation and atrial arrhythmias in critically ill trauma patients

Cited by 5 publications

References 27 publications

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Selenium as a Modulator of Redox Reactions in the Prevention and Treatment of Cardiovascular Diseases

Antioxidants in Arrhythmia Treatment—Still a Controversy? A Review of Selected Clinical and Laboratory Research

Cardiac Arrhythmias in Trauma Patients Undergoing Pericardiotomy: A Retrospective Analysis

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