Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelaković, Goran; Nikolova, Dimitrinka; Gluud, Lise Lotte; Simonetti, Rosa G; Gluud, Christian

doi:10.1002/14651858.cd007176.pub2

Cited by 519 publications

(265 citation statements)

References 1,038 publications

Supporting

Mentioning

246

Contrasting

Unclassified

Order By: Relevance

“…However, the failure of single-nutrient supplementation to protect against CVD (7) and cancers (8,9) highlighted the fact that it was important to develop a more holistic view of food intake. Foods are biochemically complex and contain compounds that may interact with each other.…”

mentioning

confidence: 99%

The use of predefined diet quality scores in the context of CVD risk during urbanization in the South African Prospective Urban and Rural Epidemiological (PURE) study

Dolman

Wentzel-Viljoen

Jerling

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Urbanization is generally associated with increased CVD risk and accompanying dietary changes. Little is known regarding the association between increased CVD risk and dietary changes using approaches such as diet quality. The relevance of predefined diet quality scores (DQS) in non-Western developing countries has not yet been established. Design: The association between dietary intakes and CVD risk factors was investigated using two DQS, adapted to the black South African diet. Dietary intake data were collected using a quantitative FFQ. CVD risk was determined by analysing known CVD risk factors. Setting: Urban and rural areas in North West Province, South Africa. Subjects: Apparently healthy volunteers from the South African Prospective Urban and Rural Epidemiological (PURE) study population (n 1710). Results: CVD risk factors were significantly increased in the urban participants, especially women. Urban men and women had significantly higher intakes of both macro-and micronutrients with macronutrient intakes well within the recommended CVD guidelines. While micronutrient intakes were generally higher in the urban groups than in the rural groups, intakes of selected micronutrients were low in both groups. Both DQS indicated improved diet quality in the urban groups and good agreement was shown between the scores, although they seemed to measure different aspects of diet quality. Conclusions: The apparent paradox between improved diet quality and increased CVD risk in the urban groups can be explained when interpreting the cut-offs used in the scores against the absolute intakes of individual nutrients. Predefined DQS as well as current guidelines for CVD prevention should be interpreted with caution in non-Western developing countries.

show abstract

mentioning

confidence: 99%

The use of predefined diet quality scores in the context of CVD risk during urbanization in the South African Prospective Urban and Rural Epidemiological (PURE) study

Dolman

Wentzel-Viljoen

Jerling

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…This trend has been driven by a combination of factors including recent disappointing negative findings from supplementation trials of other vitamins (1) , some of which have shown harm (2) , and the evidence of pleiotropic effects of vitamin D on many body tissues (3) . A further development has been the report from the US Institute of Medicine (IOM) revising slightly higher the recommended daily intake of vitamin D (4) , which has received a mixed response from researchers and clinicians (5,6) .…”

mentioning

confidence: 99%

Vitamin D and public health: an overview of recent research on common diseases and mortality in adulthood

Scragg

2011

Public Health Nutr.

View full text Add to dashboard Cite

Objective: There is increasing interest in vitamin D and its possible health effects. The aims of the present overview are to summarise the research on common diseases for which there is substantial evidence on vitamin D, identify diseases where vitamin D may be beneficial and discuss the public health implications of these findings. Conclusions: Cohort studies show that baseline 25(OH)D levels predict increased risk of fractures, colorectal cancer, CVD and all-cause mortality. These associations are weak and could be explained by confounding variables such as obesity and physical activity. Because of their potential public health significance, RCT using vitamin D doses $50 mg/d are required to determine whether vitamin D protects against these diseases.

show abstract

“…show an impact of a supplementation, especially at high doses, in antioxidant nutrients on mortality, 230 CVD or cancer [29][30][31][32][33][34][35]. These results suggest that biological antioxidant status could be viewed as a 231 surrogate marker of fruit and vegetable consumption, and more broadly of an overall better diet 232 quality.…”

Section: Fsa-nps DI and Biomarkers Of Nutritional Status 176mentioning

confidence: 99%

“…31 A priori dietary scores aiming at assessing the level of adherence to these food groups-based 32 recommendations are therefore useful tool to monitor dietary pattern evolution in the population 33 and have allowed to quantify their predictive value as regards health outcomes such as 34 cardiovascular disease and cancer [7,8]. 35 However, within a given food group, nutritional quality can largely vary, and individual food choices 36 among a specific food group can impact overall diet quality [9]. Such variability within food groups 37 cannot be grasped by dietary scores based on level of adherence to food-based recommendations.…”

mentioning

confidence: 99%

Validation of the FSA nutrient profiling system dietary index in French adults—findings from SUVIMAX study

et al. 2015

View full text Add to dashboard Cite

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Cited by 519 publications

References 1,038 publications

The use of predefined diet quality scores in the context of CVD risk during urbanization in the South African Prospective Urban and Rural Epidemiological (PURE) study

The use of predefined diet quality scores in the context of CVD risk during urbanization in the South African Prospective Urban and Rural Epidemiological (PURE) study

Vitamin D and public health: an overview of recent research on common diseases and mortality in adulthood

Validation of the FSA nutrient profiling system dietary index in French adults—findings from SUVIMAX study

Contact Info

Product

Resources

About