Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelaković, Goran; Nikolova, Dimitrinka; Gluud, Lise Lotte; Simonetti, Rosa G; Gluud, Christian

doi:10.1002/14651858.cd007176

Cited by 251 publications

(187 citation statements)

References 806 publications

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“…Unlike in animal models, the results of the interventional translational studies in humans were disappointing [42]. In fact, traditional antioxidants, such as beta-carotene and vitamin A or E supplements, may even increase mortality [43][44][45]. These rather unexpected results are usually explained by a potential interference of the treatment with the numerous physiological actions of ROS as a signaling molecule, such as the regulation of cellular redox potential or matrix metalloproteinases or the reduction of metal ions (reviewed in [46]), and a particular unfavorable chemistry.…”

Section: Ros In Ischemic Brain Injurymentioning

confidence: 99%

NADPH oxidases as therapeutic targets in ischemic stroke

Kahles

Brandes

2012

Cell. Mol. Life Sci.

121

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Reactive oxygen species (ROS) act physiologically as signaling molecules. In pathological conditions, such as ischemic stroke, ROS are released in excessive amounts and upon reperfusion exceed the body's antioxidant detoxifying capacity. This process leads to brain tissue damage during reoxygenation. Consequently, antioxidant strategies have long been suggested as a therapy for experimental stroke, but clinical trials have not yet been able to promote the translation of this concept into patient treatment regimens. As an evolution of this concept, recent studies have targeted the sources of ROS generation-rather than ROS themselves. In this context, NADPH oxidases have been identified as important generators of ROS in the cerebral vasculature under both physiological conditions in general and during ischemia/reoxygenation in particular. Inhibition of NADPH oxidases or genetic deletion of certain NADPH oxidase isoforms has been found to considerably reduce ischemic injury in experimental stroke. This review focuses on recent advances in the understanding of NADPH oxidase-mediated tissue injury in the cerebral vasculature, particularly at the level of the blood-brain barrier, and highlights promising inhibitory strategies that target the NADPH oxidases.

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Section: Ros In Ischemic Brain Injurymentioning

confidence: 99%

NADPH oxidases as therapeutic targets in ischemic stroke

Kahles

Brandes

2012

Cell. Mol. Life Sci.

121

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“…The Physicians' Health Study II showed that long-term vitamin E or vitamin E supplementation did not reduce the risk of major cardiovascular events in middle-aged and older men [38]. In Cochrane Review of 2008 (updated in 2012 [40], it was demonstrated that antioxidant supplements (beta-carotene, vitamin A, vitamin C, vitamin E, and selenium) seem to increase mortality [39]. This study included 78 randomized trials with 296,707 participants who were either healthy (primary prevention trials), or had various diseases in a stable phase: gastrointestinal, cardiovascular, neurological, ocular, dermatological, rheumatoid, renal, endocrinological, or unspecified diseases (secondary prevention trials).…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of antioxidants and fats in the context of coronary heart disease prevention among elderly people

Kolarzyk

Skop-Lewandowska

Jaworska

et al. 2018

Ann Agric Environ Med.

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-Gąsior A, Krzeszowska-Rosiek T. Dietary intake of antioxidants and fats in the context of coronary heart disease prevention among elderly people. Ann Agric Environ Med. 2018; 25(1): 131-136. doi: 10.5604/12321966.1233574 Abstract Introduction. Some literature data indicate that the proper intake of exogenic antioxidants from food and the proper intake of fats can offer significant protection against coronary heart disease. Objectives. The estimation of total antioxidant capacity of food intake on the basis of Dietary Antioxidant Index (DAI), together with an assessment of the contribution of particular food products in DAI, and the evaluation of consumption of all dietary fats and frequency of consumption of products that are a source of fats among elderly people in Krakow, Poland. Materials and method. 143 persons (73 women and 70 men) aged 65-80 were studied. None of them was under specialist medical control, including cardiological control. DAI was investigated on the basis of the Food Frequency Questionnaire (FFQ) which included 145 food items. DAI was measured using the method by Benzi and expressed as FRAP (the ability to reduce Fe 3+ to Fe

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“…Une revue Cochrane de 67 essais randomisant 232 500 participants entre supplé -mentation en antioxydants (vitamine A, bê tacarotè ne, vitamine C, vitamine E, sé lé nium) à doses nutritionnelles et placebo a é té publié e en 2008 [10]. La supplé mentation en antioxydants ne diminuait pas la mortalité , en pré vention primaire comme secondaire.…”

Section: Antioxydants Et Cancerunclassified

Diet and cancer: what evidences and recommendations?

Vano

Schneider

2009

Oncologie

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One third of cancer deaths are attributable to dietary/ nutritional factors. A high vegetable and/or fruit intake decreases the risk of upper aero-digestive tract (UADT) lung, esophageal and stomach cancer. Red and processed meats increase the risk of colorectal cancer (CRC). Alcoholic beverages increase the risk of UADT, lung, esophageal, CRC and breast cancer. Obesity promotes esophageal, CRC, postmenopausal breast cancer, endometrial and pancreatic cancer. Antioxidant supplementation has no preventive effect and may increase cancer risk. It is advised to limit alcoholic drinks as much as possible, to maintain an average body weight, to be physically active, to eat only a little red and processed meat, to eat at least five portions of fruit and vegetables a day, and to avoid dietary supplements.

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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Cited by 251 publications

References 806 publications

NADPH oxidases as therapeutic targets in ischemic stroke

NADPH oxidases as therapeutic targets in ischemic stroke

Dietary intake of antioxidants and fats in the context of coronary heart disease prevention among elderly people

Diet and cancer: what evidences and recommendations?

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