Antioxidant System and Endoplasmic Reticulum Stress in Cataracts

Zhang, Xi; Liu, Bingqing; Lal, Kevin; Liu, Haihua; Tran, Myhoa; Zhou, Manyu; Ezugwu, Chimdindu; Gao, Xin; Dang, Terry; Au, My-Lien; Brown, Erica; Wu, Hongli; Liao, Yan

doi:10.1007/s10571-023-01427-4

Cell Mol Neurobiol

2023

DOI: 10.1007/s10571-023-01427-4

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Antioxidant System and Endoplasmic Reticulum Stress in Cataracts

Xi Zhang,

Bingqing Liu,

Kevin Lal

et al.

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2024

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Cited by 9 publications

(1 citation statement)

References 126 publications

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“…The Kelch-like-ECH associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) system is a crucial regulator of cellular stress response and redox balance. 16 Activation of Nrf2 has shown promise as a therapeutic target for enhancing antioxidant capacity and alleviating CILI. 17,18 However, ongoing debates persist in the clinical and scientific communities regarding the role of Nrf2 in carcinogenesis and cancers because of variations in contextual factors.…”

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confidence: 99%

Selection of GalNAc-Conjugated siKeap1 as Disease-Specific Delivery System for Chemotherapy-Induced Liver Injury and Chronic Liver Disease

You,

Tian,

Song

et al. 2024

Nano Lett.

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Chemotherapy-induced liver injury (CILI) is a pressing concern in cancer patients. One promising approach involves activating nuclear factor erythroid 2-related factor 2 (Nrf2) to mitigate CILI. However, selectively activating liver Nrf2 without compromising chemotherapy's efficacy has remained elusive. Herein, two RNAi delivery strategies were explored: lipid nanoparticle (LNP) and N-acetylgalactosamine (GalNAc) delivery systems loaded with siRNA designed to silence Kelch-like-ECH associated protein 1 (Keap1) by aiming for liver-specific Nrf2 activation. Remarkably, siKeap1-LNP exhibited unintended tumor targeting alongside liver effects, thereby potentially promoting tumor progression. Conversely, siKeap1-GalNAc did not compromise chemotherapy efficacy and outperformed the conventional Nrf2 activator, bardoxolone, in mitigating CILI. This study proposes siKeap1-GalNAc as a promising therapeutic avenue for liver injury. Importantly, our study bridges a crucial gap concerning the delivery system for liver targeting but not tumor targeting and underscores the importance of selecting nucleic acid delivery systems tailored to specific diseases, not just to specific organs.

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confidence: 99%

Selection of GalNAc-Conjugated siKeap1 as Disease-Specific Delivery System for Chemotherapy-Induced Liver Injury and Chronic Liver Disease

You,

Tian,

Song

et al. 2024

Nano Lett.

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Cyclic RGD conjugated PEG-PLGA nanoparticle enhances preventative effect of bilirubin on the development of ultraviolet-B (UVB)-induced cataract

Jin,

Huang,

Jin

et al. 2024

Chemical Engineering Journal

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Oxidative and endoplasmic reticulum stress in diabetes-related hearing loss: Protective effects of thioredoxin

Xu,

Zhong,

Zhu

et al. 2024

Life Sciences

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Antioxidant System and Endoplasmic Reticulum Stress in Cataracts

Cited by 9 publications

References 126 publications

Selection of GalNAc-Conjugated siKeap1 as Disease-Specific Delivery System for Chemotherapy-Induced Liver Injury and Chronic Liver Disease

Selection of GalNAc-Conjugated siKeap1 as Disease-Specific Delivery System for Chemotherapy-Induced Liver Injury and Chronic Liver Disease

Cyclic RGD conjugated PEG-PLGA nanoparticle enhances preventative effect of bilirubin on the development of ultraviolet-B (UVB)-induced cataract

Oxidative and endoplasmic reticulum stress in diabetes-related hearing loss: Protective effects of thioredoxin

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