Antioxidant therapy for management of oxidative stress induced hypertension

Abstract

Hypertension is considered as the most common risk factor for cardiovascular diseases, also is regarded as a leading cause of the mortality and morbidity worldwide. The mechanisms underlying the pathological process of hypertension are not completely explained. However, there is growing evidence that increased oxidative stress plays an important role in the pathophysiology of hypertension. Several preclinical studies and clinical trials have indicated that antioxidant therapy is important for management of hypertension, using antioxidants compounds such as alpha tocopherol (Vit E) and ascorbic acid (Vit C), polyphenols with others and some antihypertensive drugs that are now in clinical use (e.g. ACEIs, ARBs, novel B-blockers, dihydropyridine CCBs) which have antioxidative pleiotropic effects. The purpose of this review is to highlight the importance of antioxidant therapy for management of oxidative stress induced hypertension. Furthermore, we review the current knowledge in the oxidative stress and its significance in hypertension.

Optimization of a diagnostic platform for oxidation–reduction potential (ORP) measurement in human plasma

“…Numerous antioxidant therapies have been proposed for treatment of shock and other medical conditions, but few methods are available to identify those individuals with an imbalance in oxidative stress most likely to benefit from these treatments [18,19,20,21]. In this study, we optimized a protocol for point-of-care estimation of oxidative stress in human plasma.…”

Dihydropyridines as Calcium Channel Blockers: An Overview

“…Nifedipine may possibly meet the requirements of being a selective antagonist by exerting its best effect on the vessels compared to the myocardium, and also has no (or very little) effect on nodal tissue or atrioventricular conduction; The problem is that its selectivity for vessels is associated with rapid uptake and plasma distribution, as well as a rapid rate of fixation to its "receptor" in the complex of the calcium ion channel, for this reason produces rapid peripheral vasodilation. As a consequence, the autonomic nervous system is stimulated, determining a rapid and significant increase of the heart rate, which forces to concomitant treatment with β-blocker or a preparation of prolonged release [24][25][26][27][28][29].…”

Extracellular superoxide dismutase and its role in cancer

“…Development of therapeutic intervention strategies for ameliorating the negative effects of oxidative stress have produced both pharmacological and gene therapy based approaches for preventing tissue injury in disease models [58 59]. SODs have shown promise as treatment in the laboratory, yet clinical efforts are stymied by source purification, clearance rate, and distribution [60–62].…”