Antioxidant Therapy in Idiopathic Tinnitus: Preliminary Outcomes

Savastano, Marina; Brescia, Giuseppe; Marioni, Gino

doi:10.1016/j.arcmed.2006.12.004

Cited by 43 publications

(43 citation statements)

References 23 publications

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“…Free radicals increase in the serum of patients with idiopathic tinnitus; the administration of antioxidants decreases the number of free radicals in the serum with an amelioration of symptoms. 21 In this study, we demonstrated that the stimulation of a particular set of acupoints associated with the oral administration of antioxidants could decrease the symptoms of subjective tinnitus. The treatment benefit lasted more than 3 months after the end of the therapy and there were no reported adverse effects.…”

Section: Discussionmentioning

confidence: 71%

Auricular Acupuncture Plus Antioxidants in the Treatment of Subjective Tinnitus: A Case Series

Shaladi

Crestani²,

Saltari

2009

Medical Acupuncture

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Background: Subjective tinnitus is the perception of an acoustic sensation that is not audible by other people, without any external sound stimulus. Objective: To assess the benefit of auricular acupuncture and antioxidants on subjective tinnitus. Design: A prospective questionnaire including an 11-point scale of the subjective volume, an 11-point scale of the severity of tinnitus, and the Zung Self-Rating Anxiety Scale were used to assess the response to acupuncture. Patients and Setting: We recruited 13 patients who reported symptoms of tinnitus for 3 to 5 years. We evaluated the patients at 3 times: at baseline, 1 month, and 4 months. The study was carried out during a 10-month period between November 2007 and August 2008 in an outpatient facility in Italy. Intervention: We treated the patients with oral antioxidants and auricular acupuncture 2 times a week, for 4 weeks; each acupuncture session lasted 30 minutes. Main Outcome Measures: The reduction of the subjective volume, of the severity of the tinnitus, and the improvement of the emotional state. Results: From baseline to 1 month, there was a reduction of 4.25 points (t ¼ 0.357; P ¼ .76) of the subjective volume of the tinnitus; a reduction of 5 points (t ¼ 0.544; P ¼ .64) of the severity of the tinnitus; and a reduction of 18.9 points (t ¼ 0.387; P ¼ .74) on the anxiety scale. No variation was registered between months 1 and 4, but patients reported improved sleep. Conclusions: Auricular acupuncture plus oral antioxidants nonsignificantly reduced the noise and the intensity of subjective tinnitus in this cohort. Larger trials including randomized treatment are needed to confirm this outcome.

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Section: Discussionmentioning

confidence: 71%

Auricular Acupuncture Plus Antioxidants in the Treatment of Subjective Tinnitus: A Case Series

Shaladi

Crestani²,

Saltari

2009

Medical Acupuncture

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“…Cardiovascular problems can cause problems in blood supply to labyrinthine artery and this causes hypoxia in the outer hair cells of the Table 1. Causes of tinnitus 7,[11][12][13][14][15] .…”

Section: Medicinal Plants and Tinnitusmentioning

confidence: 99%

“…Previous researches on tinnitus with unknown cause showed that oxidative stress events are one of the proposed mechanisms of tinnitus 6 in a way that antioxidants are known as one of the effective measures in reducing the severity of tinnitus 7 . Oxidative stress processes often occur in the context of an imbalance in the concentration of rare elements used in the construction of antioxidant enzymes 8 .…”

Section: Introductionmentioning

confidence: 99%

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Mahmoudian-Sani¹,

Hashemzadeh‐Chaleshtori²,

Asadi-Samani³

et al. 2017

The International Tinnitus Journal

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Introduction: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical-psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus. Evidence Acquisitions: Google Scholar, Directory of Open Access Journals (DOAJ), PubMed, LISTA (EBSCO) and Web of Science have been searched. Results: There are many studies on the therapeutic effect of Ginkgo biloba on patients with tinnitus. Most findings are in contrast with each other so that some of studies reported that Ginkgo biloba is effective in the treatment of tinnitus and other studies referred to it as ineffective herbal medicine. Generally, according to the previous studies and the present study, it can mention that the Ginkgo biloba may somewhat improve tinnitus. Conclusion: Since tinnitus is multifactorial, it is recommended to evaluate patients individually based on the cause of tinnitus, treatment formulas, and different doses of Ginkgo biloba at the more extensive level in future studies.

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“…The indirect ROS markers 48 h before and after medical treatment were quantitatively analysed in 31 consecutive patients with unilateral idiopathic tinnitus (44). They underwent an 18-week oral treatment with a mixture of phospholipids and vitamins (glycerophosphorylcholine, glycerophosphorylethanolamine, beta-carotene, vitamin C, vitamin E).…”

Section: Free Radical Scavengersmentioning

confidence: 99%

Tinnitus treatment: Are drugs effective?

Pyykkö

Zou

Kentala

et al. 2008

Audiological Medicine

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This work evaluates trials on drug treatment of tinnitus. Tinnitus is a subjective complaint and there are no objective outcome measures. The rationale of treating tinnitus is based on two major therapeutic models: 1) cochlear origin of tinnitus in that tinnitus is alleviated by cochlear mechanisms reducing the cytotoxicity induced by the metabolic stress, influencing neural transmission and restoring the cochlear homeostasis. 2) central origin of tinnitus that involves similar mechanisms to neuropathic pain. In controlled studies there are no convincing results that any treatment will be beneficial for tinnitus. There are some exceptions with drugs that antagonize neurotransmission in glutaminergic receptors, and also possibly melatonin when sleep disorders are associated with tinnitus. The central neurotransmitter agonists and antagonists seem not to be effective. Finally, novel nano-technological advances in targeted drug carrier technology that can administer growth factors and gene machinery may be useful in future treatment of tinnitus.

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Antioxidant Therapy in Idiopathic Tinnitus: Preliminary Outcomes

Cited by 43 publications

References 23 publications

Auricular Acupuncture Plus Antioxidants in the Treatment of Subjective Tinnitus: A Case Series

Auricular Acupuncture Plus Antioxidants in the Treatment of Subjective Tinnitus: A Case Series

Ginkgo biloba in the treatment of tinnitus: An updated literature review

Tinnitus treatment: Are drugs effective?

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