Antioxidant, thrombolytic, cytotoxic and antibacterial activities of leaves of Vitex peduncularis

Abstract

Vitex peduncularis (Verbenaceae), a perennial tree, is locally utilized for possessing multifaceted pharmacological properties including analgesic, antimalarial, anti-angina, antidiabetic, antioxidant, anti-inflammatory and hepatoprotective. Hence, this study aims to evaluate their antioxidant, thrombolytic, cytotoxic and antibacterial activities from the methanolic crude extract and its various solvent fractions. Data from antioxidant and thrombolytic assay displayed that Kupchan partitioned chloroform soluble fraction revealed the maximum phenolic content (73.39 mg of GAE/g of extract), DPPH free radical scavenging activity (26.69 μg/ml) and thrombolytic activity (37.35%). In brine shrimp lethality evaluation, the LC50 values indicate that the most cytotoxic compound was found to be from ethyl acetate soluble fraction (LC50 6.73 μg/ml). Finally, antibacterial activity of different fractions showed that both chloroform and methanolic fraction possessed mild activity against the tested bacteria. The potential biological effects of the crude fractions have been demonstrated demanding future studies of the isolated compounds to assess these activities. Bangladesh J. Sci. Ind. Res. 57(4), 239-246, 2022

Comparative Pharmacological Evaluation of Mangrove Plant Xylocarpus mekongensis Pierre and Associated Fungus

“…It just needs a tiny amount of test material, which is affordable and does not require aseptic methods. This bioassay evaluates cytotoxicity, antibacterial activities, pesticidal effects, and various pharmacologic actions [24]. The findings of this study suggest that chemicals with biological activity, such as those that inhibit enzymes and interfere with ion channels, are found in the bark extracts of X. mekongensis and endophytes.…”

Importance of conserving Vitex peduncularis: A depleting forest resource with immense ethnopharmacological uses

“…An enlarged calyx encloses fruit, and seeds are exalbuminous [21] . The species has numerous vernacular or regional names, e.g., Chang Xu Jing in China, Korobaong in Bengali, Horina in Chittagong [24] , Charaiygorwa in Hindi ('charai' means bird and 'gorwa' means leg) [25] and Goda in Bangladesh [21,26] . The hardcoated seed of V. peduncularis is naturally propagated from the seed despite having a very low natural germination rate.…”

“…[10] . Bark on stems and leaves both have antifungal, antibacterial, antioxidant, antidepressant [56] , insecticidal effects [10] , larvicidal efficacy against A. stephe and C. quinquefasciatus [57, 58,] , thrombolytic and cytotoxic properties [26] . Kirtikar and Basu [59] reported that in Chota Nagpur regions, localities use its bark to address aches and pains.…”