Antioxidant treatment normalizes nitric oxide production, renal sodium handling and blood pressure in experimental hyperleptinemia

Bełtowski, Jerzy; Wójcicka, Grażyna; Jamróz-Wiśniewska, Anna; Borkowska, Ewelina; Marciniak, Andrzej

doi:10.1016/j.lfs.2005.02.013

Cited by 20 publications

(20 citation statements)

References 55 publications

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“…Consistent with this, Na þ ,K þ -ATPase activity was higher in leptin-treated compared to the control group [98]. Most of these effects were prevented by coadministration of O 2 À scavenger, tempol, or NAD(P)H oxidase inhibitor, apocynin [99,100]. These data suggest that NAD(P)H oxidase-derived superoxide curtails NO availability, thus contributing to increased Na þ reabsorption, vasoconstriction and hypertension in leptin-treated rats (Fig.…”

Section: Hypertensive Effect Of Chronic Hyperleptinemiasupporting

confidence: 56%

Role of leptin in blood pressure regulation and arterial hypertension

Bełtowski

2006

Journal of Hypertension

192

123

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Leptin is a 16-kDa protein secreted by white adipose tissue that is primarily involved in the regulation of food intake and energy expenditure. Plasma leptin concentration is proportional to the amount of adipose tissue and is markedly increased in obese individuals. Recent studies suggest that leptin is involved in cardiovascular complications of obesity, including arterial hypertension. Acutely administered leptin has no effect on blood pressure, probably because it concomitantly stimulates the sympathetic nervous system and counteracting depressor mechanisms such as natriuresis and nitric oxide (NO)-dependent vasorelaxation. By contrast, chronic hyperleptinemia increases blood pressure because these acute depressor effects are impaired and/or additional sympathetic nervous system-independent pressor effects appear, such as oxidative stress, NO deficiency, enhanced renal Na reabsorption and overproduction of endothelin. Although the cause-effect relationship between leptin and high blood pressure in humans has not been demonstrated directly, many clinical studies have shown elevated plasma leptin in patients with essential hypertension and a significant positive correlation between leptin and blood pressure independent of body adiposity both in normotensive and in hypertensive individuals. In addition, leptin may contribute to end-organ damage in hypertensive individuals such as left ventricular hypertrophy, retinopathy and nephropathy, independent of regulating blood pressure. Here, current knowledge about the role of leptin in the regulation of blood pressure and in the pathogenesis of arterial hypertension is presented.

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Section: Hypertensive Effect Of Chronic Hyperleptinemiasupporting

confidence: 56%

Role of leptin in blood pressure regulation and arterial hypertension

Bełtowski

2006

Journal of Hypertension

192

123

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“…The assay procedure was described in detail in previous report (Beltowski et al 2005). Briefly, in the initial stage antigen was captured by a solid phase monoclonal antibody and was detected with biotin-labeled goat polyclonal anti-nitrotyrosine antibodies.…”

Section: Biochemical Markers Of Oxidative Stressmentioning

confidence: 99%

The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity

et al. 2010

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“…The dose of PD98059 was established according to the studies of Muthalif et al (2000a,b), in which this compound reduced blood pressure in deoxycorticosterone-salt-induced and in angiotensin II-induced hypertension. Groups receiving tempol, apocynin and prazosin without leptin were not included because these compounds have no effect on blood pressure and oxidative stress in animals not treated with leptin (Bełtowski et al, 2005b).…”

Section: Animals and Experimental Protocolmentioning

confidence: 99%

“…Nitrotyrosine level is an indirect marker of ONOO − generation. NT was measured by the EIA method using BIOXYTECH Nitrotyrosine-EIA kit (Oxis International, Portland, OR, USA) as previously described (Bełtowski et al, 2005b). Hydrogen peroxide in plasma and urine was measured by the FOX method based on the oxidation of Fe 2+ to Fe 3+ , which subsequently forms a blueviolet chromogen with xylenol orange (Yuen and Benzie, 2003).…”

Section: Indices Of Oxidative and Nitrosative Stressmentioning

confidence: 99%

“…Previously, we have demonstrated that experimental hyperleptinemia induced in the rat by 7-day administration of exogenous leptin reduces whole-body and intrarenal production of nitric oxide (NO) due to excessive formation of reactive oxygen species (ROS) (Bełtowski et al, 2004(Bełtowski et al, , 2005b. In addition, renal Na + ,K + -ATPase activity is increased in leptintreated animals and may drive enhanced tubular Na + reabsorption.…”

Section: Introductionmentioning

confidence: 99%

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