Antioxidant Treatment with .ALPHA.-Tocopherol Improves Erectile Function in Hypertensive Rats

Ushiyama, Masayuki; Kuramochi, Tomoya; Yagi, Shinji; Katayama, Shigehiro

doi:10.1291/hypres.31.1007

Cited by 27 publications

(19 citation statements)

References 14 publications

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“…The intracavernosal pressure increase induced by pelvic nerve stimulation was augmented and nNOS and eNOS expression levels in the corpus cavernosum were increased in the SHR treated with a herbal formulation consisting of the seeds of Lycium chinense, Cornus officinalis, Rubus coreanus, and so on, compared with the nontreated SHR [111]. Relaxations in response to electrical field stimulation of the corpus cavernosum were improved and tissue cyclic GMP levels were greater in SHRs fed a-tocopherol compared with the controls; this treatment also decreased thiobarbituric acid-reacting substance levels and increased superoxide dismutase activity in the serum and corpus cavernosum [112]. The antioxidant therapy may contribute to improve the penile erectile function in hypertensive patients.…”

Section: Antihypertensive Therapy In Relation To Neuronal Nitric Oxidmentioning

confidence: 92%

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase

Toda¹,

Ayajiki²,

Okamura³

2009

Journal of Hypertension

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Nitric oxide formed by neuronal nitric oxide synthase (nNOS) in the brain, autonomic inhibitory (nitrergic) nerves, and heart plays important roles in the control of blood pressure. Activation of nitrergic nerves innervating the systemic vasculature elicits vasodilatation, decreases peripheral resistance, and lowers blood pressure. Impairment of nitrergic nerve function, as well as endothelial dysfunction, results in systemic and pulmonary hypertension and decreased regional blood flow. Blockade of nNOS activity in the brain, particularly the medulla and hypothalamus, causes systemic hypertension. Under hypertensive states, such as those in spontaneously hypertensive and Dahl salt-sensitive rats, the expression of the nNOS gene in the brain is increased; this appears to counteract the activated sympathetic function in the vasomotor center. The present article summarizes information concerning the modulation of systemic and pulmonary hypertension through nNOS-derived nitric oxide produced in the brain and periphery.

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Section: Antihypertensive Therapy In Relation To Neuronal Nitric Oxidmentioning

confidence: 92%

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase

Toda¹,

Ayajiki²,

Okamura³

2009

Journal of Hypertension

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“…Chez l'animal, il a été mis en évidence une augmentation du stress oxydatif ainsi que la fabrication de ROS [23]. La nicotinamide adénine dinucleotide phosphate (NADPH) oxydase serait en partie responsable de la production de ROS et des altérations de la SOD [24,25]. Chez le rat hypertendu atteint de dysfonction érectile, il a été mis en évidence une diminution de l'activité de la SOD entraî-nant une augmentation des ROS dans les tissus caverneux.…”

Section: L'hypertension Artérielleunclassified

“…Chez le rat hypertendu atteint de dysfonction érectile, il a été mis en évidence une diminution de l'activité de la SOD entraî-nant une augmentation des ROS dans les tissus caverneux. [25] L'hypercholestérolémie L'hypercholestérolémie est considérée comme un facteur de risque indépendant de dysfonction érectile [26]. Deux études ont démontré que l'hypercholestérolémie entraînait une diminution de l'activité de la eNOS et de la production de eNO provoquant une nette diminution de la vasoactivité des corps caverneux [27,28].…”

Section: L'hypertension Artérielleunclassified

Dysfonction érectile et cellules endothéliales caverneuses

Galiano

Pignot

Costa

et al. 2010

Progrès en Urologie

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“…A growing number of research has indicated that antioxidants can improve ED [7,12,13,14,15]. The purpose of this study was to investigate whether PNS are able to improve the erectile function of rats with DMED and whether the antioxidant effect of PNS underlies this mechanism.…”

Section: Introductionmentioning

confidence: 99%

<b><i>Panax notoginseng</i></b> Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction

He²,

Lin³

et al. 2014

Urol Int

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Panax notoginseng saponins (PNS), which have an antioxidant property, are a widely used traditional Chinese medicine. In this study we investigated whether PNS can improve erectile function in rats with erectile dysfunction and the underlying mechanism by using a rat diabetic erectile dysfunction model. The rats were randomly divided into four groups: three PNS-treated groups (50, 100 and 150 mg/kg) and one saline-treated control group. Four weeks post treatment, electrostimulation was applied to the cavernous nerve and intracavernous pressure was measured to assess erectile function. Malondialdehyde, superoxide dismutase and glutathione were detected in the penises of all rats. Ultrastructural changes in the penises were examined by electron microscopy. Expression of Akt was detected by immunohistochemistry. The results showed that intracavernous pressure was increased in PNS-treated groups (100 and 150 mg/kg) compared to the control group. The levels of superoxide dismutase, glutathione and Akt were increased (p < 0.05) while that of malondialdehyde was decreased in the PNS groups. Ruptured endothelium, impaired smooth muscle cells and thrombus in the penises were detected by electron microscopy in the control group, but not in the PNS groups (10 and 150 mg/kg). The results suggest that PNS improves erectile function in diabetic rats. This improvement was associated with increased Akt expression, suppressed oxidative stress and restored functions of endothelial cells and smooth muscle cells in the penis.

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Antioxidant Treatment with .ALPHA.-Tocopherol Improves Erectile Function in Hypertensive Rats

Abstract: There is no known treatment for erectile dysfunction (ED) in hypertensive patients. We tested whether or not antioxidative therapy improves ED in the setting of hypertension. Spontaneously hypertensive rats

Cited by 27 publications

References 14 publications

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase

Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase

Dysfonction érectile et cellules endothéliales caverneuses

<b><i>Panax notoginseng</i></b> Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction

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