Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets

Qin, Fuzhong; Rounds, Naomi K.; Mao, Weike; Kawai, Keisuke; Liang, Chang‐seng

doi:10.1016/s0008-6363(01)00323-6

Cited by 61 publications

(35 citation statements)

References 62 publications

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“…Isoproterenol induces lipid peroxidation and norepinephrine increases hydroxyl free radicals and oxidized glutathione in animal hearts. [12][13][14] Therefore, adrenergic receptor blockers are useful for catecholamine-induced oxidative stress. Actually, Kukin et al 16 reported that not only carvedilol but also metoprolol, a ␤ 1 -selective blocker, reduced plasma lipid peroxidation in patients with heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9] Experimental studies have shown the beneficial effects of antioxidants for prevention of heart failure. 5,14,32 However, the effectiveness of antioxidants for human patients with heart failure has not been clarified. Keith et al 33 reported that supplementation with vitamin E did not result in any significant improvement in patients with heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] It has been shown that isoproterenol induces lipid peroxidation and that norepinephrine generates hydroxyl free radicals in animal hearts. 12,13 Therefore, ␤-blocker therapy may prevent oxida-tive stress in patients with heart failure.…”

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confidence: 99%

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Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

et al. 2002

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Background-Oxidative stress has been implicated in the pathogenesis of heart failure. However, direct evidence of oxidative stress generation in the human failing myocardium has not been obtained. Furthermore, the effect of carvedilol, a vasodilating ␤-blocker with antioxidant activity, on oxidative stress in human failing hearts has not been assessed. This study was therefore designed to determine whether levels of lipid peroxides are elevated in myocardia of patients with dilated cardiomyopathy (DCM) and whether carvedilol reduces the lipid peroxidation level. Methods and Results-Endomyocardial biopsy samples obtained from 23 patients with DCM and 13 control subjects with normal cardiac function were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with DCM. Expression was distinct in the cytosol of cardiac myocytes. Myocardial HNE-modified protein levels in patients with DCM were significantly increased compared with the levels in control subjects (PϽ0.0001). Endomyocardial biopsy samples from 11 patients with DCM were examined before and after treatment (mean, 9Ϯ4 months) with carvedilol (5 to 30 mg/d; mean dosage, 22Ϯ8 mg/d). After treatment with carvedilol, myocardial HNE-modified protein levels decreased by 40% (PϽ0.005) along with amelioration of heart failure. Conclusions-Oxidative stress is elevated in myocardia of patients with heart failure. Administration of carvedilol resulted in a decrease in the oxidative stress level together with amelioration of cardiac function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

et al. 2002

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“…Theblocking effects of carvedilol may be important, because catecholamines such as isoproterenol or norepinephrine induce oxidative stress in the myocardium. 8,34,35 Other effects, such as anti-ischemic effects, including negative chronotropic effects via -receptors, and the direct antioxidative effect of carvedilol, may contribute to the reduction of oxidative stress. 8 Carvedilol reduced oxidative DNA damage with amelioration of heart failure, but only decreased the oxidative stress level by 19%.…”

Section: Circulation Journal Vol70 August 2006mentioning

confidence: 99%

Elevated Levels of Oxidative DNA Damage in Serum and Myocardium of Patients With Heart Failure

Kono

Nakamura

Kimura

et al. 2006

Circ J

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“…22 Alternatively, -blockers inhibit the phosphorylation of PKA and decrease the cyclic AMP-mediated Ca 2+ 24 which induces hypertrophy 25 and apoptosis. 26 Antioxidants attenuate LV hypertrophy 27,28 and apoptosis. 29 LV hypertrophy and myocardial fibrosis caused by apoptosis increase the stiffness leading to diastolic dysfunction.…”

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confidence: 99%

Rationale, Design, and Organization of the Diastolic Heart Failure Assessment Study in Tohoku District (DIAST)

Shinozaki

Watanabe

Kikuchi

et al. 2004

Circ J

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, MD; the DIAST InvestigatorsBackground High mortality and a high readmission rate characterize diastolic heart failure (DHF), but evidence-based therapeutic strategies have not been established for DHF. Methods The aim of a multicenter, randomized open trial (the Diastolic Heart Failure Assessment Study in Tohoku District, DIAST) is to evaluate the safety and prognostic efficacy of the multiple action non-selective -blocker carvedilol in 160 patients with DHF (left-ventricular ejection fraction ≥50%). The target dose of carvedilol is 10 mg twice a day and the mean follow-up is estimated to be 2 years. The primary endpoints are to evaluate (1) all-cause mortality or hospitalization, (2) cardiovascular mortality or hospitalization and (3) worsening heart failure. The secondary endpoints are to assess (1) cardiovascular events, (2) the individual components of the above combined endpoints, (3) the duration of hospitalization, (4) the functional class and exercise capacity and (5) the safety and tolerability. All patients' data are processed using an original registration system on an internet homepage. Several substudies to assess neurohumoral factors, heart rate variability, oxidative stress and sleep apnea will clarify the pathophysiology of DHF. Conclusions The DIAST will contribute to establish therapeutic guidelines for DHF. (Circ J 2004; 68: 660 -664)

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Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets

Cited by 61 publications

References 62 publications

Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium

Elevated Levels of Oxidative DNA Damage in Serum and Myocardium of Patients With Heart Failure

Rationale, Design, and Organization of the Diastolic Heart Failure Assessment Study in Tohoku District (DIAST)

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