Antioxidant, α-amylase, and acetylcholinesterase inhibitory activities of <i>Hertia cheirifolia</i> essential oils: Influence of plant organs and seasonal variation

Rahali, Najoua; Mehdi, Sameh; Younsi, Faten; Boussaïd, Mohamed; Messaoud, Chokri

doi:10.1080/10942912.2017.1352597

Cited by 16 publications

(21 citation statements)

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“…Species of other genera, such as Hertia cheirifolia , showed significant variation in the composition of the essential oil between the different parts of the plant, where the flower buds and flowers were characterized by a higher content of drimane-type sesquiterpenes (34.08% and 32.55%, respectively), while the leaves and fruits predominantly contained α-pinene (35.63% and 33.17%, respectively) [41]. In addition, the essential oils of the roots, leaves, branches, inflorescences, and fruits of Kelussia odoratissima Mozaff.…”

Section: Resultsmentioning

confidence: 99%

Chemical profile of Lippia thymoides, evaluation of the acetylcholinesterase inhibitory activity of its essential oil, and molecular docking and molecular dynamics simulations

et al. 2019

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The essential oils of the fresh and dry flowers, leaves, branches, and roots of Lippia thymoides were obtained by hydrodistillation and analyzed using gas chromatography (GC) and GC-mass spectrometry (MS). The acetylcholinesterase inhibitory activity of the essential oil of fresh leaves was investigated on silica gel plates. The interactions of the key compounds with acetylcholinesterase were simulated by molecular docking and molecular dynamics studies. In total, 75 compounds were identified, and oxygenated monoterpenes were the dominant components of all the plant parts, ranging from 19.48% to 84.99%. In the roots, the main compounds were saturated and unsaturated fatty acids, having contents varying from 39.5% to 32.17%, respectively. In the evaluation of the anticholinesterase activity, the essential oils (detection limit (DL) = 0.1 ng/spot) were found to be about ten times less active than that of physostigmine (DL = 0.01ng/spot), whereas thymol and thymol acetate presented DL values each of 0.01 ng/spot, equivalent to that of the positive control. Based on the docking and molecular dynamics studies, thymol and thymol acetate interact with the catalytic residues Ser203 and His447 of the active site of acetylcholinesterase. The binding free energies (ΔG bind) for these ligands were-18.49 and-26.88 kcal/mol, demonstrating that the ligands are able to interact with the protein and inhibit their catalytic activity.

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Section: Resultsmentioning

confidence: 99%

Chemical profile of Lippia thymoides, evaluation of the acetylcholinesterase inhibitory activity of its essential oil, and molecular docking and molecular dynamics simulations

et al. 2019

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Section: Resultsmentioning

confidence: 99%

“…The methanolic and chloroformic extracts of the aerial parts of H. pallens contain a large amount of sesquiterpenes [1]. The methanolic extract of H. cheirifolia has significant antioxidant activity [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies of H. cheirifolia essential oil showed the presence of monoterpenes and sesquiterpene compounds [14]. Zellagui et al [23] found the drimenin was the main constituent of the essential oil of H. cheirifolia; however, the study of Segueni et al [15] showed that the majorities' compounds were monoethyl-hexyl phthalate and valeranone.…”

Section: Introductionmentioning

confidence: 99%

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Chemical composition, antimicrobial activity and chromosome number of Hertia cheirifolia L. from Algeria

Ounoughi

Ramdani

Lograda

et al. 2020

Acta Scientifica Naturalis

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The aims of this work are to investigate the chemical composition, the antibacterial activity of the essential oil and the chromosome numbers of two populations of Hertia cheirifolia. The samples were collected in the flowering stage, in eastern Algeria locality. The aerial parts of H. cheirifolia were submitted to a hydro-distillation. GC and GC / MS analysed the chemical compositions of the obtained essential oils. The antibacterial activity of essential oils was evaluated using the disks diffusion method against ten bacterial strains. For karyotypic analysis, the squashing method is used. Fifty-eight compounds representing 98.93% of the total oil were identified in H. cheirifolia. The chemical composition is dominated by the presence of major products, α-pinene (48.49 - 53.85%) and Germacrene-D (2.64 - 12.66%). Two distinct chemical breeds were identified, the α-pinene-spathulenol of Batna population, and the α-pinene-germacrene-D of Setif population. The essential oil of H. cheirifolia has a moderate activity against bacteria tested. In contrast, the strains E. coli ATCC 25922, P. syringae ATCC 53543 and E. fecalis ATCC 49452 are resistant to H. cheirifolia essential oils. The observations of root cells meristematic at metaphase of H. cheirifolia gave a diploid chromosome number 2n = 2x = 20, with a basic chromosome number (x= 10).

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“…In fact, many herbal plants possess the ability to prevent some diseases, e.g., diabetes or Alzheimer's disease [6][7][8][9][10]. Basil is widely used in traditional medicine in different cultures and is also known for its culinary uses [11].…”

Section: Introductionmentioning

confidence: 99%

Potential Acetylcholinesterase, Lipase, α-Glucosidase, and α-Amylase Inhibitory Activity, as well as Antimicrobial Activities, of Essential Oil from Lettuce Leaf Basil (Ocimum basilicum L.) Elicited with Jasmonic Acid

et al. 2020

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The aim of this study was to investigate the influence of the elicitation with jasmonic acid on the biological activities of essential oils (EOs) from lettuce leaf basil (Ocimum basilicum L.). Specifically, 0.01 µM jasmonic acid (JA1), 1 µM jasmonic acid (JA2), and 100 µM jasmonic acid (JA3) were used as elicitors. The results indicated that the elicitation increased the acetylcholinesterase, lipase, and α-amylase inhibitory activity of essential oils. A significant difference in α-glucosidase inhibition was noted only for the JA3 extract (IC50 = 0.81 µL/mL), as this activity was lower than in the control sample without elicitation (IC50 = 0.68 µL/mL). The studied basil EOs exhibited similar activity against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). Based on the value of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentrations (MBC), the best antimicrobial activity was observed for JA2 and JA3.

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Antioxidant, α-amylase, and acetylcholinesterase inhibitory activities of Hertia cheirifolia essential oils: Influence of plant organs and seasonal variation

Cited by 16 publications

References 50 publications

Chemical profile of Lippia thymoides, evaluation of the acetylcholinesterase inhibitory activity of its essential oil, and molecular docking and molecular dynamics simulations

Chemical profile of Lippia thymoides, evaluation of the acetylcholinesterase inhibitory activity of its essential oil, and molecular docking and molecular dynamics simulations

Chemical composition, antimicrobial activity and chromosome number of Hertia cheirifolia L. from Algeria

Potential Acetylcholinesterase, Lipase, α-Glucosidase, and α-Amylase Inhibitory Activity, as well as Antimicrobial Activities, of Essential Oil from Lettuce Leaf Basil (Ocimum basilicum L.) Elicited with Jasmonic Acid

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