Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer

Ahmed, Kazi Rejvee; Rahman, Md. Masudur; Islam, Md. Nahidul; Fahim, Md. Maharub Hossain; Rahman, Md Ataur; Kim, Bonglee

doi:10.1016/j.biopha.2024.116497

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.116497

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Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer

Kazi Rejvee Ahmed,

Md. Masudur Rahman,

Md. Nahidul Islam

et al.

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2024

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Cited by 6 publications

References 135 publications

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In‐silico and In‐vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF‐κB Inhibitors in Oral Cancer

Gotsurve,

Das,

Kutre

et al. 2024

Chemistry & Biodiversity

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Oral cancer is a global health concern, particularly because of its aggressive tissue invasion and metastases, holding 16th position on occurrence among all carcinoma worldwide. The aberrated transcription factor NF‐κB1 influences development and spread of oral cancer, making it a potential therapeutic target. This study investigated the therapeutic potential of a few natural compounds from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla in the treatment of oral cancer. Two FDA‐approved drugs (5‐fluorouracil, Docetaxel) and 16 natural compounds, including Artocarpin, Artocarpanone, Cycloartocarpin from Artocarpus heterophyllus; Berberine, Hydrastine, Magnoflorine, Palmatine Chloride, Tetrahydropalmatine from Tinospora cordifolia; and 5‐Hydroxyarborinine, 5‐Hydroxynoracronycine, 1‐Hydroxy‐3‐methoxy‐10‐methyl‐9‐acridone, Des‐N‐methylacronycine, Des‐N‐methylnoracronycine, Kokusagenine, Noracronycin, Skimmianine from Glycosmis pentaphylla were examined using in‐silico techniques. Among the 16 natural compounds studied, Hydrastine shown the highest binding energy (‐6.87 kcal/mol) against NF‐κB1, surpassing all other drugs, including the standards 5‐fluorouracil (‐4.04 kcal/mol) and docetaxel (‐2.4 kcal/mol). Further molecular dynamics simulations and in‐vitro experiments verified Hydrastine's exceptional anti‐cancer activity. The results of in‐vitro were well‐aligned with the findings of in‐silico, revealing considerable cytotoxicity, apoptosis induction, and cell cycle arrest. The findings revealed natural compounds’ potential as safer, more effective alternatives to current cancer therapeutics, opening up new avenues for oral cancer treatment.

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In‐silico and In‐vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF‐κB Inhibitors in Oral Cancer

Gotsurve,

Das,

Kutre

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

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Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Sirotkin,

Harrath

2024

Biomedicines

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Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, such as its ability to act as an antioxidant, reduce inflammation, and inhibit the growth of cancer cells. The purpose of this review is to provide a summary of the existing knowledge regarding the effects of apigenin on female reproductive systems and its dysfunctions. Apigenin can influence reproductive processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, cell renewal and viability, ovarian blood supply, and the release of reproductive hormones. It could stimulate ovarian folliculogenesis, as well as ovarian and embryonal cell proliferation and viability, which can lead to an increase in fertility and influence the release of reproductive hormones, which may exert its effects on female reproductive health. Furthermore, apigenin could inhibit the activities of ovarian cancer cells and alleviate the pathological changes in the female reproductive system caused by environmental pollutants, harmful medications, cancer, polycystic ovarian syndrome, ischemia, as well as endometriosis. Therefore, apigenin may have potential as a biostimulator for female reproductive processes and as a therapeutic agent for certain reproductive diseases.

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Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics

Rahman,

Shaikh,

Gupta

et al. 2024

Biomedicines

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Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, and thereby cell survival. Oral health is an essential component of integrated well-being, and it is critical for developing therapeutic interventions to understand the molecular mechanisms underlying the maintenance of oral homeostasis. However, because of the complex dynamic relationship between autophagy and oral health, associated treatment modalities have not yet been well elucidated. Determining how autophagy affects oral health at the molecular level may enhance the understanding of prevention and treatment of targeted oral diseases. At the molecular level, hard and soft oral tissues develop because of complex interactions between epithelial and mesenchymal cells. Aging contributes to the progression of various oral disorders including periodontitis, oral cancer, and periapical lesions during aging. Autophagy levels decrease with age, thus indicating a possible association between autophagy and oral disorders with aging. In this review, we critically review various aspects of autophagy and their significance in the context of various oral diseases including oral cancer, periapical lesions, periodontal conditions, and candidiasis. A better understanding of autophagy and its underlying mechanisms can guide us to develop new preventative and therapeutic strategies for the management of oral diseases.

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Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer

Cited by 6 publications

References 135 publications

In‐silico and In‐vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF‐κB Inhibitors in Oral Cancer

In‐silico and In‐vitro Investigation of Flavonoids and Alkaloids from Artocarpus heterophyllus, Tinospora cordifolia, and Glycosmis pentaphylla as Potential NF‐κB Inhibitors in Oral Cancer

Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders

Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics

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