Antioxidants and carcinogenesis: butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats

Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats

“…It has been reported that synthetic and natural phenolic compounds (antioxidants) may inhibit chemical carcinogenesis in various organs, including the liver [ 15,19,20]. It is considered that these compounds, in general, prevent the formation of carcinogens from precursor chemicals, or scavenge reactive forms of carcinogenic agents [ 151.…”

PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

“…Of importance is the observation that PBB has many properties similar to phenobarbital (31,32) and butylated hydroxytoluene (31)(32)(33)(34), in that these chemicals can inhibit chemically induced carcinogenesis if administered prior to the carcinogen, but they act as promoters when given after carcinogen exposure. These observations in animals, plus our in vitro results, lead us to believe that, i7l vivo, PBB could be a promoter of certain types of tumors under conditions where the organism has been previously initiated.…”

Effects of butylated hydroxyanisole and butylated hydroxytoluene on dna adduct formation and arylamine N‐acetyltransferase activity in human bladder tumour cells

“…The amounts of the acetylated product and remaining non-acetylated substrate were determined by HPLC. 20,21 An aliquot of the reaction mixture was injected onto a C18 reversed-phase column (Spherisorb, 4.6 × 250 mm) of a Beckman HPLC instrument (pump 168 and detector 126) and eluted at a flow rate of 1.2 ml min −1 . For 2-AF and 2-AAF, the solvent system was 20 mM KH 2 PO 4 (pH 4.5)-CH 3 CN(53 : 47) with detection at 280 nm.…”