Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge

Tolouian, Ramin; Tolouian, Audrey C; Dastan, Farzaneh; Farhangi, Vida; Peymani, Payam; Saeifar, Sanam; Montes, Oscar Felipe Borja; Mohmoodnia, Leila; Khosravifarsani, Mohammadreza; Sadighpour, Tella

doi:10.34172/npj.2022.10556

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Reactive Species (RS) are free radicals that are composed of various types of activated oxygen or nitrogen. Free Radicals Originate from Oxygen (ROS) and Nitrogen (RNS) 22 leading to changes in a cellular membrane or intracellular molecules with a relationship imbalance between RS and the antioxidant defence system depicted in Figure 2 23 . RS is constantly produced during normal physiological processes, although it is possibly removed by the antioxidant defense system 24 .…”

Section: Pathogenesis Of Aminoglycosides Induced Nephrotoxicity (Pain)mentioning

confidence: 99%

Exploring Nephroprotective Properties of Wedelia chinensis: In Vitro, In Silico, and In Vivo Investigations

Gautam,

Venkatachalam,

Senthilkumar

2024

JNR

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The purpose of this research work is to investigate the nephroprotective efficacy of Wedelia chinensis leaf extracts against gentamicin-induced nephrotoxicity for in vitro, in silico, and in vivo techniques. The extracts of Wedelia chinensis leaf rich in flavonoids were subjected to an in silico method for ligands and target proteins. The results of the in vitro antioxidant study of extracts were tested for cytoprotective MTT assay and anti-inflammatory efficacy by protein denaturation assay using Human Embryonic Kidney cells (HEK293). The in vivo nephroprotective potential of the extract was evaluated with the two doses of 250mg/kg and 500mg/kg body weight in gentamicin nephrotoxicity in rats. The biochemical parameters observed for changes in the histopathology of the kidney. While comparing with other extracts of Wedelia chinensis Hydroalcoholic Extract (WCHAE) shows great binding affinity with bonding interactions of flavonoids and phenolics-based ligands observed with the target proteins that provided early information. The in vitro cell lines study revealed no cytotoxicity and better anti-inflammatory effect on HEK293 cells with cytoprotective and nephroprotective efficacy of WCHAE. The in vivo nephroprotective activity improved at a dose of 500mg/kg of WCHAE than Wedelia chinensis Ethanolic Extract (WCEE). The histopathological findings revealed the improvement in gentamicin-induced renal toxicity by the WCHAE orally treated group compared to normal and negative control groups. These results of WCHAE are more satisfactorily effective than WCEE with marked in vitro antioxidant, and cytoprotective effects in HEK293 cells. In in silico docking, it shows good interaction scores of ligands for target proteins like (kidney injury molecule) KIM-1 and Neutrophil Gelatinase-Associated Lipocalin (NAGAL) that helps to correlate nephroprotective potential benefits of antioxidants in plant extracts against gentamicin induced nephrotoxicity in rats.

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Section: Pathogenesis Of Aminoglycosides Induced Nephrotoxicity (Pain)mentioning

confidence: 99%

Exploring Nephroprotective Properties of Wedelia chinensis: In Vitro, In Silico, and In Vivo Investigations

Gautam,

Venkatachalam,

Senthilkumar

2024

JNR

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Comprehensive Characterization of Oxidative Stress-Modulating Chemicals Using GPT-Based Text Mining

Liang,

Su,

Zhong

et al. 2024

Environ. Sci. Technol.

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The screening of hazardous environmental pollutants is hindered by the limited availability of toxicological databases. Large language model (LLM)-based text mining holds the potential to automatically extract complex toxicological information from the literature. Due to its relevance to diseases and the challenge of comprehensive characterization, oxidative stress serves as a suitable case for research by texting mining. In this study, a robust workflow utilizing a LLM (i.e., GPT-4) was developed to extract information on oxidative stress tests, including data collection, text preprocessing, prompt engineering, and performance evaluation procedures. A total of 17,780 relevant records were extracted from 7166 articles, covering 2558 unique compounds. A rising interest in oxidative stress was observed over the past two decades. A list of known prooxidants (n = 1416) and antioxidants (n = 1102) was established, with the leading chemical categories being pharmaceuticals, pesticides, and metals for prooxidants and pharmaceuticals and flavonoids for antioxidants. Structural alert analysis identified potential prooxidant (e.g., chlorobenzene, nitrobenzene, and tertiary amines) and antioxidant (e.g., flavonoid and thiol) substructures. These findings illustrate the feasibility of building toxicological databases through LLM-based text mining in a cost-efficient manner, and the information obtained from the technique holds significant promise for future applications in environmental and health research.

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Antioxidants and cisplatin nephrotoxicity; an updated review on current knowledge

Cited by 2 publications

References 24 publications

Exploring Nephroprotective Properties of <i>Wedelia chinensis: In Vitro, In Silico,</i> and <i>In Vivo</i> Investigations

Exploring Nephroprotective Properties of <i>Wedelia chinensis: In Vitro, In Silico,</i> and <i>In Vivo</i> Investigations

Comprehensive Characterization of Oxidative Stress-Modulating Chemicals Using GPT-Based Text Mining

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