Antioxidants and lipid peroxidation status in the blood of patients with alopecia

Nazıroğlu, Mustafa; Kökçam, İbrahim

doi:10.1002/1099-0844(200009)18:3<169::aid-cbf870>3.0.co;2-t

Cited by 60 publications

(45 citation statements)

References 17 publications

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“…Some studies have suggested the use of antioxidants as supplements for the treatment of AA based on these evidences. 5,13 Few human-and animal-based studies have demonstrated enhanced hair growth as a result of antioxidant use. 28,29 We think that properly conducted interventional studies are required to elucidate the role of antioxidants in the management of AA patients.…”

Section: Association Between Aa and Oxidative Damage Products/ Oxidantsmentioning

confidence: 99%

“…4 Several studies have investigated the levels of oxidative stress markers, antioxidants, and oxidative damage products in plasma, erythrocytes, and scalp tissues of AA patients. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] We conducted this systematic review and meta-analysis to investigate the association between AA and oxidative stress and to clarify the inconsistent findings across previous studies.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress in alopecia areata: a systematic review and meta‐analysis

Acharya

Mathur

2019

Int J Dermatology

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Background Several studies have investigated the oxidative stress parameters in alopecia areata (AA) patients with variable results. This study aims to analyze the association between oxidative stress and AA based on current literature. Methods A systematic review of the existing literature was performed in PubMed, Scopus, and Cochrane databases by two authors independently. Mean and standard deviation values of oxidative stress parameters of AA patients and healthy controls were extracted for quantitative analysis. Results A total of 18 studies were included in the analysis. Patients with AA had impaired oxidative balance with elevated levels of serum malondialdehyde, nitric oxide, and total oxidant capacity and lower levels of serum superoxide dismutase, paraoxonase, glutathione peroxidase, and total antioxidant capacity. Levels of oxidative parameters were significantly higher in severe AA compared to mild/moderate AA. Heterogeneity in the baseline characteristics of the included studies and limited available data for most parameters were the limitations of this study. Conclusions Current evidence suggests that AA is associated with oxidative stress. More studies are needed to strengthen this association. Moreover, studies evaluating the role of antioxidant use in AA may be rewarding.

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Section: Association Between Aa and Oxidative Damage Products/ Oxidantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative stress in alopecia areata: a systematic review and meta‐analysis

Acharya

Mathur

2019

Int J Dermatology

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“…Vitamin E is another nutrient involved in the oxidant/antioxidant pathway, serving an instrumental role in defense against free-radical damage to the plasma membrane [89]. Investigators in Egypt assessed serum and tissue vitamin E levels in 15 patients with AA, finding lower levels in cases compared to healthy controls [90].…”

Section: Micronutrientsmentioning

confidence: 99%

“…Investigators in Egypt assessed serum and tissue vitamin E levels in 15 patients with AA, finding lower levels in cases compared to healthy controls [90]. In contrast, investigators from Turkey found no differences in vitamin E levels, but did identify lower levels of beta-carotene in AA cases vs. controls [89]. Beta-carotene is a precursor to vitamin A and an antioxidant [63].…”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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“…Few studies have recently proposed the role of oxidative stress in AA. [6][7][8] Oxidative stress is a condition of oxidant ⁄ antioxidant disequilibrium, in which increased reactive oxygen species (ROS) generation overwhelms antioxidant defence mechanisms leading to oxidative damage of cellular molecules. Of these, lipids are the most sensitive in that polyunsaturated fatty acids in cell membrane react with free radicals to form peroxidation products.…”

Section: Introductionmentioning

confidence: 99%