Antioxidants and Periodontal Diseases

Talmaç, Ahmet Cemil; Çalışır, Metin

doi:10.5772/intechopen.81815

Cited by 3 publications

(3 citation statements)

References 104 publications

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“…Several herbal extracts or natural compounds play an important role in treating various disease symptoms of periodontitis diseases due to their antioxidant properties [ 70 , 71 ]. Free radicals and reactive oxygen species play an essential role in an increased inflammatory response in the pathogenesis of periodontitis, which leads to the destruction of periodontal tissues and alveolar bone [ 8 , 72 ]. Antioxidant activity of S. baicalensis radix extract and binary mixtures were investigated by using two methods of different mechanisms, such as ABTS •+ radical cation assay and ferrous ion-chelating assay.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Chanaj-Kaczmarek

Osmałek

Szymańska

et al. 2021

IJMS

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Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, and wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel approach for periodontal diseases treatment. Two types of chitosan were employed in preliminary studies on binary mixtures with S. baicalensis radix lyophilized extract standardized for baicalin, baicalein, and wogonin. Thermosensitive hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose derivatives and evaluated in terms of rheological and mucoadhesive behavior. The presence of chitosan altered the release profile of active compounds but did not affect their in vitro permeation behavior in PAMPA assay. The synergistic effects of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-chelating activity, inhibition of hyaluronidase, and pathogen growth were observed. The thermosensitive gelling system showed shear-thinning properties, gelation temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with porcine buccal mucosa, which was enhanced in the presence of binary mixture of S. baicalensis radix extract and chitosan. The release tests showed that baicalin and baicalein were liberated in a prolonged manner with a fast onset from hydrogel formulations.

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Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Chanaj-Kaczmarek

Osmałek

Szymańska

et al. 2021

IJMS

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“…Chaplle et al [81,152,153], found lower total antioxidant concentration in the saliva of periodontitis patients when compared to health controls [24,154]. Salivary antioxidant levels (SOD, GPx, reduced GHS, ascorbic acid, alfa tocopherol, were observed to the lower in periodontal patients (Canacki) [146,[155][156][157]. In the present study, sulfhydryl (thiol), in gingival tissue, was observed in reduced quantities in the patients with gingivitis and periodontitis (groups B The pathological events which lead to the destruction of the periodontal tissues during gingival inflammation and periodontal destruction have been related to the effect of an imbalance between oxidants and antioxidants in patients with gingivitis and periodontitis (Sakalilioglu) [61,129,137].…”

Section: Discussionmentioning

confidence: 96%

“…Chaplle et al [81,152,153], found lower total antioxidant concentration in the saliva of periodontitis patients when compared to health controls [24,154]. Salivary antioxidant levels (SOD, GPx, reduced GHS, ascorbic acid, alfa tocopherol, were observed to the lower in periodontal patients (Canacki) [146,[155][156][157]. In the present study, sulfhydryl (thiol), in gingival tissue, was observed in reduced quantities in the patients with gingivitis and periodontitis (groups B and C), compared with the people from healthy group (Group A) [158,159].…”

Section: Discussionmentioning

confidence: 96%

The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases

Cerkezi,

Nakova,

Gorgoski

et al. 2024

Biomedicines

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Aim. The sulfhydryl (thiols) group of glutathione plays an important role in the neutralization of foreign organic compounds and the reduction in peroxides. The purpose of the study is to evaluate the concentration of sulfhydryl groups in the gingival tissue of healthy individuals and those with gingivitis or periodontitis, and to examine the differences between these groups. Material and methods. To assess the concentration of sulfhydryl groups (thiols) in the gingival tissue of healthy individuals and those with gingivitis or periodontitis, we used spectrophotometric analysis using dithionitrobenzoate (DTNB) as a reagent to measure the accessible sulfhydryl groups present in gingival tissue proteins. The sample was divided into three distinct groups: individuals with periodontal health, gingivitis, and periodontitis, and different indices were used to assess the periodontal status of the participants. Next, a statistical analysis was conducted to compare the concentrations of sulfhydryl groups among the different groups of patients. Conclusions. The results of this study showed significantly decreased levels of sulfhydryl (thiols) groups in gingival tissue from patients with gingivitis and periodontitis, compared with healthy people (control group). These results confirm the role of sulfhydryl (thiols) groups in defense against free radicals. They share a significant role in detoxification, signal transduction, apoptosis, and various other functions at the molecular level.

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Indicators of antioxidant protection of blood in necrotizing ulcerative gingivitis in experimental animals

et al. 2021

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This article highlights the results of a study of blood parameters in animals with simulated necrotizing ulcerative gingivitis and compares them, under the same conditions, with animals that received local treatment with a developed complex of antioxidant drugs. Following the work tasks, the nature of changes in the state of the antioxidant - prooxidant system and their influence on quantitative and functional indicators of markers of inflammatory intensity was analyzed and investigated during the pathological process in the background and without treatment with a developed complex. This work shows the changes of malonic dialdehyde concentration as an indicator of lipid peroxidation intensity in experimental animals, the level of catalase activity in the blood of animals, and antioxidant-prooxidant balance in the dynamics of necrotizing ulcerative gingivitis.

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Antioxidants and Periodontal Diseases

Cited by 3 publications

References 104 publications

Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment

The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases

Indicators of antioxidant protection of blood in necrotizing ulcerative gingivitis in experimental animals

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