Antioxidants and Whole Food Phytochemicals for Cancer Prevention

Liu, Rui Hai; Felice, Dana L.

doi:10.1021/bk-2007-0956.ch003

Cited by 12 publications

(6 citation statements)

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“…Phenolics are secondary metabolites which are not only involved in the reproduction and physiology of plant, but also associated with reduced risk of major chronic diseases due to their antioxidant, anticancer and anti-microbial activities [14,15,16]. A present finding indicated that abundant phenolics in bud, xylem and phloem could contribute to further utilization of Boehmeria nivea L. in cosmetics, textiles, and fiber reinforcements.…”

Section: Resultsmentioning

confidence: 70%

Comparative Study of Phenolic Profiles, Antioxidant and Antiproliferative Activities in Different Vegetative Parts of Ramie (Boehmeria nivea L.)

et al. 2019

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Ramie (Boehmeria nivea L.) is usually cultivated as a fiber crop, but it is also well known for its potential use in animal feeding with viable commercial applications. In this study, the phenolics profile as well as cellular antioxidant and antiproliferative activities were investigated in free and bound fractions of six different vegetative parts from Boehmeria nivea L. The highest total phenolic content was observed in bud (4585 ± 320 mg GAE/100 g DW), whereas root and petiole had the lowest total phenolic contents, 442.8 ± 9.8 and 630.9 ± 27.0 mg GAE/100 g DW, respectively. Likewise, phloem had the most abundant total flavonoids (2755 ± 184 mg CE/100 g DW), whereas the lowest flavonoid contents was found in root and petiole, 636.9 ± 44.2 and 797.4 ± 87.6 mg CE/100 g DW, respectively. Xylem and bud depicted remarkable antioxidant and antiproliferative activities, which could be explained by their diverse phenolic composition, especially chlorogenic acid and epicatechin. The Boehmeria nivea L. plant might be a valuable resource for high value-added phenolic compounds used in food and non-food industries.

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Section: Resultsmentioning

confidence: 70%

Comparative Study of Phenolic Profiles, Antioxidant and Antiproliferative Activities in Different Vegetative Parts of Ramie (Boehmeria nivea L.)

et al. 2019

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“…Cancer control can be achieved by decreasing the rate of oxidative stress and enhancing antioxidant defense mechanisms. In this context the role of F/V and dietary redox-active phytochemicals in reducing the risk of cancer including BC [ 11 , 27 , 30 , 34 ], by regulating antioxidant defense mechanisms and redox signaling, has long been described [ 35 – 37 ]. Dermal carotenoids can be regarded as biomarkers of the body antioxidant status [ 16 , 38 ], as well as of fruit and vegetable intake in nutritional studies [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Raman Spectroscopic Measurements of Dermal Carotenoids in Breast Cancer Operated Patients Provide Evidence for the Positive Impact of a Dietary Regimen Rich in Fruit and Vegetables on Body Oxidative Stress and BC Prognostic Anthropometric Parameters: A Five‐Year Study

Perrone

Pintaudi

Traina

et al. 2016

Oxidative Medicine and Cellular Longevity

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Dermal carotenoids are a feasible marker of the body antioxidative network and may reveal a moderate to severe imbalance of the redox status, thereby providing indication of individual oxidative stress. In this work noninvasive Resonance Raman Spectroscopy (RRS) measurements of skin carotenoids (skin carotenoid score (SCS)) were used to provide indications of individual oxidative stress, each year for five years, in 71 breast cancer (BC) patients at high risk of recurrence. Patients' SCS has been correlated with parameters relevant to BC risk, waist circumference (WC), and body mass index (BMI), in the aim of monitoring the effect of a dietary regimen intended to positively affect BC risk factors. The RRS methodological approach in BC patients appeared from positive correlation between patients' SCS and blood level of lycopene. The level of skin carotenoids was inversely correlated with the patients' WC and BMI. At the end of the 5 y observation BC patients exhibited a significant reduction of WC and BMI and increase of SCS, when strictly adhering to the dietary regimen. In conclusion, noninvasive measurements of skin carotenoids can (i) reveal an oxidative stress condition correlated with parameters of BC risk and (ii) monitor dietary-related variations in BC patients.

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“…Thus, cancer control can be achieved by decreasing the rate of oxidative stress and enhancing antioxidant defense mechanisms. The potential role of dietary antioxidants present in nutraceuticals in reducing the risk of cancer by suppressing the state of oxidative stress has been well documented in the literature 23–25 …”

Section: Role Of Nutraceuticals Against Neoplastic Developmentmentioning

confidence: 99%

“…The potential role of dietary antioxidants present in nutraceuticals in reducing the risk of cancer by suppressing the state of oxidative stress has been well documented in the literature. [23][24][25] Another major cause of neoplastic development is the dysregulation of body homeostasis, a fundamental characteristic of living beings. The balance between cell proliferation and apoptosis is a critical step in the maintenance of homeostasis.…”

Section: Role Of Nutraceuticals Against Neoplastic Developmentmentioning

confidence: 99%

Combinatorial strategies employing nutraceuticals for cancer development

Shukla

George

2011

Annals of the New York Academy of Sciences

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Cancer is the second leading cause of death worldwide. Therefore, the fight against cancer is one of the most important areas of research in medicine, and one that possibly contributes to the increased interest in chemoprevention as an alternative approach to the control of cancer. Cancer prevention by nutraceuticals present in fruits and vegetables has received considerable attention because of their low cost and wide safety margin. A substantial amount of evidence from human, animal, and cell culture studies has shown cancer chemopreventive effects from these natural products. However, single-agent intervention has failed to produce the expected outcome in clinical trials; therefore, combinations of nutraceuticals are gaining increasing popularity. Thus, combinations of nutraceuticals that mimic real-life situations and are competent in targeting multiple targets with very little or virtually no toxicity are needed. In this review, we summarize the results of those studies that report combinatorial cancer chemopreventive action of various nutraceuticals and their combinations with anticancer drugs.

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Antioxidants and Whole Food Phytochemicals for Cancer Prevention

Cited by 12 publications

References 0 publications

Comparative Study of Phenolic Profiles, Antioxidant and Antiproliferative Activities in Different Vegetative Parts of Ramie (Boehmeria nivea L.)

Comparative Study of Phenolic Profiles, Antioxidant and Antiproliferative Activities in Different Vegetative Parts of Ramie (Boehmeria nivea L.)

Raman Spectroscopic Measurements of Dermal Carotenoids in Breast Cancer Operated Patients Provide Evidence for the Positive Impact of a Dietary Regimen Rich in Fruit and Vegetables on Body Oxidative Stress and BC Prognostic Anthropometric Parameters: A Five‐Year Study

Combinatorial strategies employing nutraceuticals for cancer development

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