Antioxidants as a Double-Edged Sword in the Treatment of Cancer

Asadi-Samani, Majid; Farkhad, Najmeh Kaffash; Mahmoudian-Sani, Mohammad Reza; Shirzad, Hedayatollah

doi:10.5772/intechopen.85468

Cited by 32 publications

(28 citation statements)

References 47 publications

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“…The statistical results between Vit C, GO-NEs, and GO showed a significant difference between GO and GO groups (p>0.01), demonstrate the high ROS scavenging ability of the GO-NEs as compared to GO. Also, GO, and GO-NEs in HC treatments substantially increase the ROS and approve the double-edged sword hypothesis 29 .…”

Section: Antioxidant Stability Assay and Cellular Ros Detection The supporting

confidence: 63%

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

Zeinali

Abbaspour‐Ravasjani

Soltanfam

et al. 2021

Preprint

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Skin cancer is the most widespread cancer worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents in routinely daily used cosmetics may prevent UV-related skin damages and skin cancers. γ-Oryzanol (GO) is a natural component derived from rice bran oil, with potential antioxidant and skin anti-aging properties. We biologically thorough studied the antioxidant and anticancer effects of GO in vitro to found the effective signaling pathways, then evaluated the sun protection factor of prepared formulation, and finally investigated the long-term preventive effects of GO-loaded nanoethosomes (GO-NEs) against UVB-induced skin cancer in mice. Our results suggest that GO-NEs could effectively prevent UVB-induced skin cancer and could be utilized as an innovative ingredient in cosmetics.

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Section: Antioxidant Stability Assay and Cellular Ros Detection The supporting

confidence: 63%

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

Zeinali

Abbaspour‐Ravasjani

Soltanfam

et al. 2021

Preprint

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“…Instead, it is known and reported in the literature (Mittler, 2017) that ROS are essential for many cell functions, such as cell proliferation, innate immune responses and differentiation. Additionally, it is reported that ROS balance is strictly important to maintain cell homeostasis, because also faint imbalances could result in toxic consequences, thus their level is kept under control (Singh et al, 2018;Asadi-Samani et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Racca

Limongi

Vighetto

et al. 2020

Front. Bioeng. Biotechnol.

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In the last years, different nanotools have been developed to fight cancer cells. They could be administered alone, exploiting their intrinsic toxicity, or remotely activated to achieve cell death. In the latter case, ultrasound (US) has been recently proposed to stimulate some nanomaterials because of the US outstanding property of deep tissue penetration and the possibility of focusing. In this study, for the first time, we report on the highly efficient killing capability of amino-propyl functionalized ZnO nanocrystals (ZnO NCs) in synergy with high-energy ultrasound shock waves (SW) for the treatment of cancer cells. The cytotoxicity and internalization of ZnO NCs were evaluated in cervical adenocarcinoma KB cells, as well as the safety of the SW treatment alone. Then, the remarkably high cytotoxic combination of ZnO NCs and SW was demonstrated, comparing the effect of multiple (3 times/day) SW treatments toward a single one, highlighting that multiple treatments are necessary to achieve efficient cell death. At last, preliminary tests to understand the mechanism of the observed synergistic effect were carried out, correlating the nanomaterial surface chemistry to the specific type of stimulus used. The obtained results can thus pave the way for a novel nanomedicine treatment, based on the synergistic effect of nanocrystals combined with highly intense mechanical pressure waves, offering high efficiency, deep and focused tissue penetration, and a reduction of side effects on healthy cells.

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“…B lymphocytes and granulocytic cells were identified among the proliferating cells when taro extract was intraperitoneally administered (1 mg/animal). Moreover, tarin-sensitized splenocytes were stimulated to release IL-2, IL-1b, TNF- α, and INF- γ, which are essential cytokines involved in the anticancer response, as mentioned previously [ 86 , 88 , 96 , 97 ].…”

Section: Bioactive Compounds and Pharmacological Properties Of Tarmentioning

confidence: 98%

“…To be used as a supportive therapy during cancer treatments, it might take into account the type of cancer, general patient status, and antioxidant dosage and type to reach the best performance. Another suggestion is to administer a single antioxidant prescribed by a unique kind of cancer, since antioxidants, as mentioned previously, can play synergic or antagonistic effects and even lead to uncontrollable effects in the human body when administrated as a non-controlled combination [ 96 ].…”

Section: Bioactive Compounds and Pharmacological Properties Of Tarmentioning

confidence: 99%

Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop

Pereira

Mattos

Corrêa

et al. 2020

IJMS

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Taro corms contain valuable bioactive molecules effective against cancer and cancer-related risk factors, such as carcinogens and biological agents, several pathophysiological conditions, including oxidative stress and inflammation, while controlling metabolic dysfunctions and boosting the immunological response. Such broad effects are achieved by the taro health-influencing compounds displaying antitumoral, antimutagenic, immunomodulatory, anti-inflammatory, antioxidant, anti-hyperglycemic, and anti-hyperlipidemic activities. Taro bioactivities are attributed to the combination of tarin, taro-4-I polysaccharide, taro polysaccharides 1 and 2 (TPS-1 and TPS-2), A-1/B-2 α-amylase inhibitors, monogalactosyldiacylglycerols (MGDGs), digalactosyldiacylglycerols (DGDGs), polyphenols, and nonphenolic antioxidants. Most of these compounds have been purified and successfully challenged in vitro and in vivo, proving their involvement in the aforementioned activities. Although these health-promoting effects have been recognized since ancient times, as well as other valuable features of taro for food profit, such as hypo-allergenicity, gluten-free, and carbohydrates with medium-glycemic index, taro crop remains underexploited. The popularization of taro intake should be considered a dietary intervention strategy to be applied to improve the overall health status of the organism and as supportive therapy to manage tumorigenesis.

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Antioxidants as a Double-Edged Sword in the Treatment of Cancer

Cited by 32 publications

References 47 publications

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

Prevention of UV-Induced Skin Cancer in Mice by Gamma Oryzanol-Loaded Nanoethosomes

Zinc Oxide Nanocrystals and High-Energy Shock Waves: A New Synergy for the Treatment of Cancer Cells

Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop

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