Antioxidants as Modulators

Bourg, Éric Le; Rattan, S. I. S.

doi:10.1007/978-94-017-0283-6_11

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…13 However, the results are not convincing enough to conclude that the feeding of VE can prolong the lifespans of animals. 13 A recent review on this issue also concluded that there is no evidence that the feeding of VE could prevent oxidative tissue damage induced during aging. 13 Many prospective and retrospective epidemiological studies in humans addressing its efficacy on human health and survivals are also inconclusive in terms of the question of whether the intake of VE as a supplement can prevent some disorders caused by oxygen-induced tissue damage or prolong the remaining life expectancy of a human population.…”

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 97%

“…It is a general trend that the supplementation with VA, β‐carotene in particular, in a pharmacological dose, is discouraged rather than encouraged for the health of humans. A number of studies are available which tested the effect of feeding vitamin E (VE) on survivals of animals, mostly Caenorhabditis elegans , as reviewed by Le Bourg 13 . However, the results are not convincing enough to conclude that the feeding of VE can prolong the lifespans of animals 13 .…”

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

“…A number of studies are available which tested the effect of feeding vitamin E (VE) on survivals of animals, mostly Caenorhabditis elegans , as reviewed by Le Bourg 13 . However, the results are not convincing enough to conclude that the feeding of VE can prolong the lifespans of animals 13 . A recent review on this issue also concluded that there is no evidence that the feeding of VE could prevent oxidative tissue damage induced during aging 13 .…”

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

“…13 A recent review on this issue also concluded that there is no evidence that the feeding of VE could prevent oxidative tissue damage induced during aging. 13 Many prospective and retrospective epidemiological studies in humans addressing its efficacy on human health and survivals are also inconclusive in terms of the question of whether the intake of VE as a supplement can prevent some disorders caused by oxygen-induced tissue damage or prolong the remaining life expectancy of a human population. [14][15][16][17] Although some authors are still quite enthusiastic about giving a pharmacological dose of VE, 16 the author is of the opinion that the intake of a pharmacological dose of VE should be discouraged, because there is no clear evidence that it is beneficial to human health and because some studies have shown an adverse effect of supplementary intake of VE.…”

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

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Pharmacological interventions in aging and age‐associated disorders

Kitani

2007

Geriatrics Gerontology Int

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In the present study, past attempts using different pharmaceuticals and chemicals which were reported to prolong lifespans of animals are critically reviewed. Despite a large number of trials in animals and humans, the validity of supplementation of antioxidant vitamins such as vitamins A, E and C for improving human health remains unresolved at present. A recent approach using antioxidant mimetics called the EUK series which, despite an initial enthusiastically reported success in prolonging the lifespan of nematodes, remains again unsettled because of the failure in reproducing the initial success by follow-up studies. a-Phenyl-tert-butylnitrone and related nitrones were initially introduced as radical scavengers. Some of these (e.g. disodium 2,4-disulfophenyl-N-tertbutylnitrone) are at phase 3 clinical trials as an agent to treat cerebral stroke. This effect, however, appears at least in part to be related to signal transduction which makes these agents effective against cerebral stroke even when they are administered later than its onset. (-)Deprenyl is a monoamine oxidase-B inhibitor and has some neuroprotective and anti-apoptotic effects. The drug has also been shown to prolong the lifespans of at least four different animal species. The drug upregulates superoxide dismutase and catalase activities in selective brain regions of dopaminergic nature. These effects on antioxidant enzyme activities are suspected to be causally related to its effect on lifespans of animals. Future trials using these and other drugs are expected to open new doors for interventions in aging and age-associated disorders in humans.

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Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 97%

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

Section: Antioxidant Vitamins (A E and C)mentioning

confidence: 99%

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Pharmacological interventions in aging and age‐associated disorders

Kitani

2007

Geriatrics Gerontology Int

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The Fact and Fiction of Nutritional Claims About Health and Longevity

Bourg

2021

Healthy Ageing and Longevity

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For centuries, various feeding regimens have been proposed to live longer with a better health. However, in many cases, they have not been proven to have any positive effect, and they can even have negative ones. This chapter reviews the claims of various regimens (e.g. detox diets, fasting). It is doubtful that they could increase human lifespan and improve health, provided one adopts a balanced regime with no excessive intake and avoids junk food.

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