Antioxidants entrapment in polycaprolactone microparticles using supercritical assisted injection in a liquid antisolvent

Palazzo, Ida; Campardelli, Roberta; Reverchon, Ernesto

doi:10.1016/j.fbp.2020.07.010

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…In this process, carbon dioxide has the role of a co-solute, whereas water has the role of the antisolvent. SAILA technique has been successfully applied for the micro/nanonization of pure compounds [148][149][150][151][152] or for the attainment of polymer/drug coprecipitates [146,153,154]. The organic solvents commonly used for this process are acetone and ethanol; however, in some cases, isopropanol has also been used.…”

Section: Production Of Nanoparticles By Using Co 2 As a Co-solutementioning

confidence: 99%

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

Franco

Marco

2021

Applied Sciences

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Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to their dissolution rate inadequate to treat the pathology of interest. A large drug particle size creates an additional problem if a specific site of action in the human body has to be reached. For this reason, active ingredient size reduction using micronization/nanonization techniques is a valid approach to improve the efficacy of active compounds. Supercritical carbon-dioxide-assisted technologies enable the production of different morphologies of different sizes, including nanoparticles and nanocrystals, by modulating operating conditions. Supercritical fluid-based processes have numerous advantages over techniques conventionally employed to produce nanosized particles or crystals, such as reduced use of toxic solvents, which are completely removed from the final product, ensuring safety for patients. Active compounds can be processed alone by supercritical techniques, although polymeric carriers are often added as stabilizers, to control the drug release on the basis of the desired therapeutic effect, as well as to improve drug processability with the chosen technology. This updated review on the application of supercritical micronization/nanonization techniques in the pharmaceutical field aims at highlighting the most effective current results, operating conditions, advantages, and limitations, providing future perspectives.

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Section: Production Of Nanoparticles By Using Co 2 As a Co-solutementioning

confidence: 99%

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

Franco

Marco

2021

Applied Sciences

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“…The Supercritical Antisolvent technique has been widely used for the precipitation and encapsulation of pharmaceutical compounds as recently reviewed [28]. Some examples found in the literature about drug encapsulation with supercritical fluids involve polymers whose mechanical and biological properties are far from the ELRs, as encapsulation of ibuprofen or antioxidants with poly(l-lactic acid), EUDRAGIT L100 ® or polycaprolactone, among others [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Production of elastin-like recombinamer-based nanoparticles for docetaxel encapsulation and use as smart drug-delivery systems using a supercritical anti-solvent process

Vallejo

González‐Valdivieso

Santos

et al. 2021

Journal of Industrial and Engineering Chemistry

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“…The microparticles tend to be spherical particles ranging in size from 1 to 1000 µm [ 11 ]. They are composed of natural polymers (sodium alginate [ 12 ], carrageenan [ 13 ], chitosan [ 14 ], and gellan gum [ 15 ]), and synthetic ones (polylactide [ 16 ], and poly (lactic-co-glycolic acid) (PLGA) [ 17 ], and polycaprolactone [ 18 ]. The microparticles can be divided into two groups: microspheres and microcapsules [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

Stachowiak

Kowalonek

2021

Materials

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Gelatin/polyvinylpyrrolidone/hydroxyethyl cellulose/glycerol porous matrices with microspheres made of sodium alginate or pectin and sodium alginate were produced. A surfactant was loaded into these microparticles. The microspheres were characterized using optical microscopy, scanning electron microscopy SEM, and laser diffraction particle size analyzer. For the matrices, the density, porosity, swelling capacity, dissolution in phosphate saline buffer were determined and SEM, mechanical, and thermogravimetric studies were applied. The results showed that the size of the two-component microspheres was slightly larger than that of single-ingredient microparticles. The images confirmed the spherical shape of the microparticles. The prepared matrices had high water uptake ability and porosity due to the presence of hydrophilic polymers. The presence of microparticles in the matrices caused a decrease in these parameters. Degradation of the composites with the microspheres was significantly faster than the matrix without them. The addition of microparticles increased the stiffness and toughness of the prepared materials. The efficiency of the thermal decomposition main stage was reduced in the samples with microspheres, whereas a char residue increased in these composites.

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Antioxidants entrapment in polycaprolactone microparticles using supercritical assisted injection in a liquid antisolvent

Cited by 7 publications

References 37 publications

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review

Production of elastin-like recombinamer-based nanoparticles for docetaxel encapsulation and use as smart drug-delivery systems using a supercritical anti-solvent process

Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate

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