Antioxidants, Enzyme Inhibitors, and Biogenic Compounds in Grain Extracts of Barleys

Maliar, Tibor; Slaba, Gabriela; Nemeček, Peter; Maliarová, Mária; Benková, Michaela; Havrlentová, Michaela; Ondrejovič, Miroslav; Kraic, Ján

doi:10.1002/cbdv.201400419

Cited by 6 publications

(4 citation statements)

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“…Experimental data evaluated by the correlation analysis revealed several correlations ( Table ). Some of them were consistent with those observed in hop, oat and barley [ ][ ][ ] but others were different. No correlations between TPC and other compounds, inhibitory and antioxidant activities were detected in poppy extracts.…”

Section: Resultssupporting

confidence: 86%

“…On the contrary, correlations between TPC and antioxidant activity were identified in extracts from hop cones, oat and barley grains. [ ][ ][ ] Antioxidant activity in poppy grain extracts correlated mainly with TFC, TTC, TAC, and TPAC ( Table ). Biogenic amines (TAC) correlated with AA RP , supporting the existence of their antioxidant properties in biological systems .…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant and Proteinase Inhibitory Activities of Selected Poppy (Papaver somniferum L.) Genotypes

Krošlák

Maliar

Nemeček

et al. 2017

Chemistry & Biodiversity

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Poppy seeds (Papaver somniferum L.) belong to tasty food ingredients however, they should be considered also as valuable source of biologically active compounds. Content of selected metabolites, antioxidant and proteinase inhibitory activities were analyzed in vitro in extracts from seeds of fifteen poppy genotypes. Considerable variation in all parameters was detected within the set of analyzed poppy genotypes. The genotype Major expressed the highest antioxidant activity determined by all four methodological approaches (DPPH, ABTS, FRAP, RP). The genotype MS 423 exhibited the highest inhibitory activities against trypsin, thrombin and collagenase. Very specific position among all had the genotype Redy. Its grain extract reached significantly high levels in 9 out of 14 measured parameters (TPC, TFC, TTC, TAC, FRAP, RP, inhibitory activities against trypsin, thrombin, collagenase). Edible grains of poppy are valuable source of natural compounds which may be beneficial in pathological states associated with oxidative stress or increased proteinase activities.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Antioxidant and Proteinase Inhibitory Activities of Selected Poppy (Papaver somniferum L.) Genotypes

Krošlák

Maliar

Nemeček

et al. 2017

Chemistry & Biodiversity

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“…The proteinases were selected as the third group of variables (secondary metabolites content, antioxidant activity parameters). As the result, the presented paper represents a continuity of several, yet published papers with identical methodology and alternate plant subjectbarley (Maliar et al 2015), oat (Krošlák et al 2016) and poppy (Krošlák et al 2017), enabling comparison and discussion of obtained results. Further, the selected secondary metabolites are main carriers of antioxidant activity as well as proteinase inhibition activity in the plant tissue (Meijersen et al 1991;Fink et al 2000;Maliar et al 2015;Yu et al 2018).…”

Section: Determination Of Proteinase Inhibition Activity Parametersmentioning

confidence: 87%

Biologically valuable components, antioxidant activity and proteinase inhibition activity of leaf and callus extracts of Salvia sp.

Vulganová¹,

Maliar²,

Maliarová³

et al. 2019

Nova Biotechnologica Et Chimica

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Sage is medicinal plant, known for its antioxidant and anti-inflammatory effects. Eight extract samples were tested in this study: extract from Salvia officinalis L. varieties from two different geographical localities (Jaslovské Bohunice and Pobedim, Slovakia), Salvia officinalis L., variety “bicolor”, Salvia officinalis L., variety “purpurescens”, Salvia apiana, Salvia divinorum, and two callus cultures of Salvia sclarea L. and Salvia aethiopis L. The highest values for composite parameters were observed for extract from Salvia apiana. It can be concluded that prepared sage extract samples are rich on polyphenolic acids (2 950±265 μg.mL−1 GAeq.) and amines (197±5.50 μg.mL−1 TRPeq.). HPLC analysis confirmed the dominant content of rosmarinic acid in the extracts; the highest content was detected in the Salvia apiana extract (1 120±15 μg.mL−1). Extract from Salvia apiana expressed too the highest antioxidant activity (1 710 – 4 669 μg.mL−1TEAC). Similarly, the highest inhibition activity was observed for this extract on thrombin (57±3.3 %) and on other proteinases (over 80 %). Spearman correlation analysis and PCA analyses revealed a coherence between antioxidant activity of samples and their content of rosmarinic acid as well as inhibitory activity towards particular proteases, and revealed the significance of thiol based secondary metabolites. Cluster analysis demonstrates the differences of Salvia apiana extract from extracts of S. officinalis L., the group of S. divinorum extract and from callus cultures.

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“…Their development and occurrence are thought to be closely linked to oxidative stress [ 8 ]. Furthermore, certain enzymes, such as α-amylase, α-glucosidase, lipase, angiotensin-converting enzyme, urokinase, and pancreatic enzymes, are considered promising drug targets for metabolic diseases prevention and treatment [ 9 , 10 , 11 ]. Polyphenols, a class of aromatic hydroxy derivatives, have strong antioxidant activity and can inhibit free radical-induced polymerization chain reactions.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

et al. 2023

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Five different solvent extracts of highland barley bran were analyzed and compared for their polyphenol profile, antioxidant activity, and α-glucosidase and α-amylase inhibitory activities. The highland barley bran acetone extract had the highest total phenolic content, total flavonoid content, and antioxidant capacity. It was followed by the methanol and ethanol extracts, while n-butanol and ethyl acetate extracts exhibited lower measured values. Diosmetin, luteolin, protocatechuic acid, vanillic acid, ferulic acid, phlorogucinol, diosmin, isoquercitrin, catechin, and isovitexin were among the most abundant phenolic compounds identified in different solvent extracts, and their concentrations varied according to the solvent used. The highest α-glucosidase and α-amylase inhibitory activity were observed in the ethyl acetate extract of highland barley bran, followed by the acetone and methanol extracts. In contrast, n-butanol and ethanol extracts exhibited lower measured values. The different solvent extracts were effective inhibitors for α-glucosidase and α-amylase with activity reaching to 34.45–94.32% and 22.08–35.92% of that of positive control acarbose, respectively. There were obvious correlations between the phenolic content and composition of different solvent extracts and their in vitro antioxidant activity, α-glucosidase inhibition activity and α-amylase inhibition activity. Black barley bran is an excellent natural raw material for developing polyphenol-rich functional foods and shows good antioxidant and hypoglycemic potential to benefit human health.

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Antioxidants, Enzyme Inhibitors, and Biogenic Compounds in Grain Extracts of Barleys

Cited by 6 publications

References 61 publications

Antioxidant and Proteinase Inhibitory Activities of Selected Poppy (Papaver somniferum L.) Genotypes

Antioxidant and Proteinase Inhibitory Activities of Selected Poppy (Papaver somniferum L.) Genotypes

Biologically valuable components, antioxidant activity and proteinase inhibition activity of leaf and callus extracts of Salvia sp.

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

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