Antioxidants for female subfertility

Showell, Marian; Mackenzie‐Proctor, Rebecca; Jordan, Vanessa; Hart, Roger

doi:10.1002/14651858.cd007807.pub2

Cited by 118 publications

(45 citation statements)

References 110 publications

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“…Although, PCOS is considered as a hormonedependent disorder, recent evidence proposed the substantial role of oxidative stress (OS) and chronic low-grade inflammation in the pathogenesis of PCOS and its metabolic associations [1,4,5]. We have previously shown the role of oxidative and nitrosative stress and inflammatory responses (overproduction of cytokines) in the pathogenesis of hyperandrogenism-induced rat PCO [6,7].…”

Section: Introductionmentioning

confidence: 93%

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Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

et al. 2015

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Section: Introductionmentioning

confidence: 93%

“…It is estimated that 40% to 50% of cases of infertilities or subfertilities in couples are caused by female reproductive disorders [1]. Polycystic ovarian syndrome (PCOS) as a lifetime complex multigenic endocrinopathy is the leading cause of anovulatory infertility in women of reproductive age [2].…”

Section: Introductionmentioning

confidence: 99%

Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

et al. 2015

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“…Only one article was removed over duplication. Further 18 articles were excluded (Bjelakovic et al, 2012;Chen & Lina, 2016;Consales et al, 2014;Farquhar et al, 2017;Garolla et al, 2014;Hart et al, 2015;Li et al, 2016;MacArthur et al, 2014;Nicoletti et al, 2016;Nisenblat et al, 2016;Pourmand et al, 2014;Povey et al, 2012;Rubes et al, 1998;Showell et al, 2013;Showell et al, 2014;Skalkidou et al, 2017;Van et al, 2017;Varshini et al, 2012) after reviewing the titles and abstracts. Full papers were obtained for the remaining 5 articles and reviewing were done thoroughly (Figure 1).…”

Section: Studies Selectedmentioning

confidence: 99%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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“…[8][9][10][11] Recent studies showed a positive association between total antioxidant capacity and follicular fluid (FF) estradiol levels. 12,13 The FF total antioxidant capacity was higher in oocytes that successfully fertilized, but lower where the resultant embryo survived to transfer. [14][15][16] These studies reiterate the importance of oxidative stress in female reproduction.…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF

2017

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As infertility is intimately associated with endometriosis, the levels of myeloperoxidase (MPO), a leukocyte enzyme and an oxidative stress marker, were determined in a case-control prospective study of 68 women with and without endometriosis undergoing in vitro fertilization in the outpatient fertility center within a tertiary care academic medical center. Measured values included plasma and follicular fluid (FF) concentrations of MPO, plasma estradiol, as well as oocyte quality, fertilization, implantation, and pregnancy rates in these women. In FF (mean + standard error of mean [SEM]), the MPO concentrations (ng/ mL) for controls were 4.3 + 0.37, mild endometriosis (stages I-II) 3.9 + 0.17, and moderate/severe endometriosis (stages III-IV) 16.6 + 12.5 (P < 0.0143). In FF, among patients supplemented with vitamins E and C, the MPO levels decreased significantly only in moderate/severe endometriosis from 25.3 + 22.0 ng/mL to 4.9 + 1.61 ng/mL, respectively. Plasma levels of MPO between groups did not change. Outcome data revealed a trend toward decreased percentage of mature oocytes, implantation rate, and clinical pregnancy rate with severity of endometriosis and MPO levels. Myeloperoxidase may be a potential oxidative stress target for endometriosis-associated infertility.

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Antioxidants for female subfertility

Abstract: Analysis 3.1. Comparison 3 Pentoxifylline versus placebo or no treatment/standard care, Outcome 1 Live birth; pentoxifylline vs placebo or no treatment/standard treatment (natural conceptions and undergoing fertility treatments

Cited by 118 publications

References 110 publications

Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Myeloperoxidase as a Potential Target in Women With Endometriosis Undergoing IVF

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