Antioxidants for male subfertility

Ligny, Wiep de; Smits, Roos M.; Mackenzie‐Proctor, Rebecca; Jordan, Vanessa; Fleischer, Kathrin; Bruin, Jan Peter de; Showell, Marian

doi:10.1002/14651858.cd007411.pub5

Cited by 40 publications

(57 citation statements)

References 241 publications

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“…Thirteen studies (1813 men) had data on DNA fragmentation; however, due to high heterogeneity, pooling of these results was not possible. Regarding reproductive outcomes, like the previous 2019 Cochrane review, the authors found that antioxidants may lead to increased live birth rates (OR 1.43, 95% CI 1.07 to 1.91, p = 0.02, I 2 = 44%) [ 73 ]. Again, however, only a limited number of studies included live birth rate as an endpoint (246 live births from 1283 couples in 12 small- or medium-sized studies), leading the authors to consider this increase in live birth rate “very low-certainty evidence”.…”

Section: Methods For Overcoming High Sdfmentioning

confidence: 65%

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Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines

Marinaro

2023

IJMS

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Sperm deoxyribonucleic acid (DNA) damage has recently emerged as one of the most controversial topics in male reproductive medicine. While level I evidence indicates that abnormal sperm DNA damage has substantial adverse effects on reproductive outcomes (including chance of pregnancy and risk of miscarriage), there is limited consensus on how sperm DNA fragmentation (SDF) testing should be performed and/or interpreted in clinical practice. In this article, we review: (1) how SDF is assessed, (2) cumulative evidence regarding its impact on reproductive outcomes, (3) methods for mitigating high SDF, and (4) the most recent practice guidelines available for clinicians regarding the use and interpretation of SDF testing.

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Section: Methods For Overcoming High Sdfmentioning

confidence: 65%

“…Both MOXI and FAZST were included in the most recent version of the Cochrane review, published in 2022 [ 73 ]. Of the 90 studies and over 10,000 subfertile men included in the updated systematic review, 65 studies were included in the meta-analysis.…”

Section: Methods For Overcoming High Sdfmentioning

confidence: 99%

Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines

Marinaro

2023

IJMS

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“…Overall, there is no evidence that antioxidant therapy increases the chance of miscarriage. Therefore, subfertile couples should be advised that the existing research on the efficacy of antioxidant therapy in improving male fertility is inconclusive [ 103 ]. The question of antioxidant therapy that could mitigate the toxicity of EDCs in men facing fertility problems is therefore still open, and needs to be further researched.…”

Section: Resultsmentioning

confidence: 99%

From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

2022

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Exposure to endocrine-disrupting chemicals (EDCs) may result in oxidative stress and endocrine system disturbance, which can have an impact on human reproduction and development. In male reproductive health, EDCs have been related to impaired reproductive function and male infertility, altered fetal development, and testicular germ-cell, prostate, and breast cancers. We conducted an electronic search using PubMed on endocrine disruptors related to oxidative stress and male infertility, and evaluated their association with endocrine-disrupting chemicals (bisphenols, phthalates, and parabens) in 25 articles. Higher levels of urinary bisphenols showed correlation with impaired semen quality and increased DNA damage. Considering phthalates and their metabolites, all studies found a positive association between urinary levels of phthalates and at least one semen parameter indicative of low semen quality; some studies also revealed sperm DNA damage. The studies on parabens less often revealed correlation of urinary parabens concentrations with a decrease in sperm count, as well as motility and DNA damage. Moreover, EDCs can elevate ROS production and lipid peroxidation, increase apoptosis, induce epigenetic modifications, and change the Y:X sperm chromosome ratio and sperm protein composition. Our review revealed detrimental effects of EDCs on semen quality and sperm DNA integrity—especially in BPA and phthalates, but also in parabens.

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“…While a healthy diet is certainly conducive to a healthy body and hence a potential association with gamete quality [ 120 ] and genome stability, we are a long way from concluding that the supplementation of the diet would be beneficial for male infertility. Large, randomized placebo-controlled trials are required to address this question as concluded in the last Cochrane review of antioxidants for male infertility [ 121 ].…”

Section: Discussionmentioning

confidence: 99%

Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions

et al. 2022

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Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The extent to which men with and without subfertility are exposed to several adverse lifestyle factors and the impact on sperm DNA fragmentation (SDF), sperm chromatin maturity (condensation and decondensation), stability (hypo- and hypercondensation) and sperm aneuploidy are assessed in this study. Standardized assays employing flow cytometry were used to detect genome instability in 556 samples. Semen parameters deteriorated with age, BMI, increased physical activity and smoking. Age and BMI were associated with increased SDF. Increased BMI was associated with increased hypocondensed chromatin and decreased decondensed chromatin. Increase in age also caused an increase in sex chromosome aneuploidy in sperms. Surprisingly, alcohol abuse reduced chromatin hypercondensation and drug abuse reduced SDF. Although genome instability was more pronounced in the subfertile population as compared to the fertile group, the proportion of men with at least one lifestyle risk factor was the same in both the fertile and subfertile groups. While one in three benefited from nutritional supplementation, one in five showed an increase in SDF after supplementation. Whilst the message of ‘no smoking, no alcohol, no drugs, but a healthy diet’ should be offered as good health advice, we are a long way from concluding that nutritional supplementation would be beneficial for male fertility.

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Antioxidants for male subfertility

Abstract: Trusted evidence. Informed decisions. Better health.

Cited by 40 publications

References 241 publications

Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines

Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines

From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality

Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions

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