Antioxidants for preventing and reducing muscle soreness after exercise: a Cochrane systematic review

Ranchordas, Mayur; Rogerson, David; Soltani, Hora; Costello, Joseph

doi:10.1136/bjsports-2018-099599

Cited by 30 publications

(29 citation statements)

References 77 publications

(305 reference statements)

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“…This may be particularly relevant to the heavy training loads of many high-performance athletes, as well as the competition recovery in multievents in track-and-field athletics or the programs of middledistance runners with heats and finals across several events at major competition. Other anti-inflammatory nutrients include flavonoids such as quercetin and green tea extract, plus fish oil, each of which may have a beneficial effect on delayed onset muscle soreness (Ranchordas et al, 2018). Consumption of highly colored vegetables/fruit is often advised; this advice is appropriate for elite athletes (previously mentioned), as these flavonoids (including blueberries, blackcurrants, and cherries) have a beneficial effect on exercise-induced inflammation, muscle damage, and illness (Bermon et al, 2017).…”

Section: Therapeutic Nutritional Supplements and Prophylactic Aidsmentioning

confidence: 99%

Sports Foods and Dietary Supplements for Optimal Function and Performance Enhancement in Track-and-Field Athletes

Peeling

Castell

Derave

et al. 2019

International Journal of Sport Nutrition and Exercise Metabolism

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Athletes are exposed to numerous nutritional products, attractively marketed with claims of optimizing health, function, and performance. However, there is limited evidence to support many of these claims, and the efficacy and safety of many products is questionable. The variety of nutritional aids considered for use by track-and-field athletes includes sports foods, performance supplements, and therapeutic nutritional aids. Support for sports foods and five evidence-based performance supplements (caffeine, creatine, nitrate/beetroot juice, β-alanine, and bicarbonate) varies according to the event, the specific scenario of use, and the individual athlete’s goals and responsiveness. Specific challenges include developing protocols to manage repeated use of performance supplements in multievent or heat-final competitions or the interaction between several products which are used concurrently. Potential disadvantages of supplement use include expense, false expectancy, and the risk of ingesting banned substances sometimes present as contaminants. However, a pragmatic approach to the decision-making process for supplement use is recommended. The authors conclude that it is pertinent for sports foods and nutritional supplements to be considered only where a strong evidence base supports their use as safe, legal, and effective and that such supplements are trialed thoroughly by the individual before committing to use in a competition setting.

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Section: Therapeutic Nutritional Supplements and Prophylactic Aidsmentioning

confidence: 99%

Sports Foods and Dietary Supplements for Optimal Function and Performance Enhancement in Track-and-Field Athletes

Peeling

Castell

Derave

et al. 2019

International Journal of Sport Nutrition and Exercise Metabolism

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“…The intake of polyphenols, a component of phytochemicals, has resulted in controversial findings, and their use cannot be fully supported [80]. A systematic review (50 randomized, placebo-controlled trials were included) evaluated the effects of antioxidant supplements for preventing and reducing the severity and duration of DOMS [89]. The authors concluded that there is moderate to low-quality evidence that high dose antioxidant supplementation does result in a clinically relevant reduction in muscle soreness after exercise at up to 6 hrs or at 24, 48, 72 and 96 hrs after exercise [89].…”

Section: The Role Of Oral Medications and Nutritionmentioning

confidence: 99%

“…A systematic review (50 randomized, placebo-controlled trials were included) evaluated the effects of antioxidant supplements for preventing and reducing the severity and duration of DOMS [89]. The authors concluded that there is moderate to low-quality evidence that high dose antioxidant supplementation does result in a clinically relevant reduction in muscle soreness after exercise at up to 6 hrs or at 24, 48, 72 and 96 hrs after exercise [89]. Controversially, Lynn et al reported in a recently published study a small to moderate increase in exercise-induced DOMS and c-reactive protein after the consumption of polyphenol rich bilberry juice in 21 recreationally trained runners completing a half-marathon [81].…”

Section: The Role Of Oral Medications and Nutritionmentioning

confidence: 99%

Advances in Delayed-Onset Muscle Soreness (DOMS) – Part II: Treatment and Prevention

Heiß

Lutter

Freiwald

et al. 2019

Sportverletz Sportschaden

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Delayed-onset muscle soreness (DOMS) describes an entity of ultrastructural muscle damage. The manifestation of DOMS is caused by eccentric muscle contractions or unaccustomed forms of exercise. Clinical signs include impaired muscular force capacities, painful restriction of movement, stiffness, swelling, and altered biomechanics in adjacent joints. Although DOMS is categorised as a mild type of muscle damage, it is one of the most common reasons for compromised sportive performance. In the last decade, many hypotheses have been developed to explain the aetiology of DOMS, and there are a wide range of different interventions aiming to prevent or alleviate the symptoms. Many studies have evaluated various types of cold or heat therapy, compression, massage, physical therapy or nutritional interventions. Treatment considerations focus on the primary prevention of ultrastructural lesions during exercise, the treatment of the inflammatory response that leads to DOMS, and recovery strategies for manifest DOMS. This narrative review aims to present an overview of the current treatment and preventive strategies in the field of DOMS.

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“…This may induce further inflammation and oxidative stress, leading to secondary muscle damage. In these orchestrated sequences of events, some factors seem to play important roles in muscle regeneration and remodeling 8-10 . When the excess mechanical and biochemical stress produced at the time of exercise overcome the antioxidant and anti-inflammatory capacity of the body, there will be sustained inflammation and oxidative stress, which ultimately lead to muscle injury, fatigue, and DOMS 10 .…”

Section: Introductionmentioning

confidence: 99%

“…In these orchestrated sequences of events, some factors seem to play important roles in muscle regeneration and remodeling 8-10 . When the excess mechanical and biochemical stress produced at the time of exercise overcome the antioxidant and anti-inflammatory capacity of the body, there will be sustained inflammation and oxidative stress, which ultimately lead to muscle injury, fatigue, and DOMS 10 . Given these facts, a natural product with known anti-inflammatory and antioxidant activity with a good record of accomplishment of safety may provide a better intervention to DOMS.…”

Section: Introductionmentioning

confidence: 99%

AmLexin, a Standardized blend of Acacia catechu and Morus alba, shows benefits to delayed onset muscle soreness in healthy runners

Yimam¹,

Talbott

et al. 2018

JENB

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[Purpose]Sudden and exhaustive exercise causes muscle damage accompanied by oxidative stress and inflammation, leading to muscle fatigue and soreness. AmLexin contains a standardized blend of extracts from the heartwood of Acacia catechu and the root bark of Morus alba, and is known to possess antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of this proprietary blend supplementation on muscular pain and redox balance in healthy runners, in comparison to a placebo.[Methods]A double-blind placebo-controlled clinical trial was carried out over 9 weeks in a single center. Thirty physically active male and female subjects within 18−70 years of age were randomized into AmLexin (mean age = 42.92 ± 2.48 and gender 7/5, male/female, respectively) and placebo (mean age = 41.15 ± 3.5 and gender 10/3, male/female, respectively) groups. Subjects were supplemented with 400 mg of AmLexin/day or a look-alike placebo during an 8-week training program, and for one week following a 13.1-mile half-marathon. Twenty-six subjects completed the 9-week supplementation trial.[Results]Results showed the AmLexin group experienced significantly lower levels of post-exercise pain on day 1−3 following the half-marathon compared to the placebo group. The AmLexin group also showed lower post-exercise oxidative stress and higher antioxidant capacity on days 1 and 6 following the half-marathon. These results demonstrated the rapid benefits of AmLexin on pain and oxidative stress within 1−6 days post-exercise.[Conclusion]Our data suggest that AmLexin could be a safe, effective botanical alternative for delayed onset muscle soreness.

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Antioxidants for preventing and reducing muscle soreness after exercise: a Cochrane systematic review

Cited by 30 publications

References 77 publications

Sports Foods and Dietary Supplements for Optimal Function and Performance Enhancement in Track-and-Field Athletes

Sports Foods and Dietary Supplements for Optimal Function and Performance Enhancement in Track-and-Field Athletes

Advances in Delayed-Onset Muscle Soreness (DOMS) – Part II: Treatment and Prevention

AmLexin, a Standardized blend of Acacia catechu and Morus alba, shows benefits to delayed onset muscle soreness in healthy runners

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