Antioxidants: Friend or foe?

Sarangarajan, Rangaprasad; Meera, Shoba Sreenath; Rukkumani, R.; Sankar, P.; Anuradha, G

doi:10.1016/j.apjtm.2017.10.017

Cited by 114 publications

(87 citation statements)

References 59 publications

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“…El malondialdehído (MDA) es una molécula tóxica considerada como un biomarcador del estrés oxidativo, es uno de los ejemplos de los productos finales de las reacciones de la peroxidación lipídica (18) . En esta investigación se encontró que los grupos experimentales a los que se les administró extracto hidroalcohólico de C. engleriana, a dosis de 50 y 300 mg/kg, tuvieron porcentajes de inhibición de 22 y 45%, respectivamente.…”

Section: Discussionunclassified

Efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo en ratones con lesión hepática

Mendoza-Romero¹,

Arroyo-Acevedo²

2019

Rev. per. med. integr.

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Objetivos. Evaluar el efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl“wawillay” in vivo mediante el uso de ratones con lesión hepática inducida por tetracloruro de carbono(CCL4). Materiales y métodos. Estudio experimental. Se utilizó cuatro grupos de seis ratones albinos Musmusculus - cepa Balb/c/CNPB: un grupo blanco, un grupo control que recibió vitamina E (Vitesol® E 400U.I) y dos grupos a los que se les administró extracto hidroalcohólico de Calceolaria engleriana Kraenzl“wawillay” en dosis de 50 y 300 mg/kg. Para la evaluación del efecto antioxidante in vivo se sometió a losratones a un modelo experimental de hepatotoxicidad por tetracloruro de carbono (CCL4) antes y durantelas intervenciones. Mediante la reacción del ácido tiobarbitúrico se cuantificó el malonaldialdehido (MDA)formado y se calculó el porcentaje de inhibición de peroxidación lipídica (POL) con el que se establecierondiferencias por grupos. Resultados. El tamizaje fitoquímico mostro la presencia muy abundante deflavonoides. Los porcentajes de inhibición de la POL obtenidos fueron de un 22 y 45%, para las dosisde 50 y 300 mg/kg del extracto hidroalcohólico. Si bien se encontraron diferencias significativas en lacomparación entre grupos (p>0,05), las intervenciones experimentales no superaron los resultadosdel grupo control con vitamina E (60%). Conclusiones. En las condiciones experimentales, el extractohidroalcohólico de Calceolaria engleriana Kraenz “wawillay” a dosis de 50 y 300 mg/kg presenta actividadantioxidante, siendo esta aun menor a la mostrada por el estándar (vitamina E).

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Section: Discussionunclassified

Efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo en ratones con lesión hepática

Mendoza-Romero¹,

Arroyo-Acevedo²

2019

Rev. per. med. integr.

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“…The equilibrium between ROS generation and scavenging activity by antioxidants establishes a homeostatic system. The imbalance disrupted by impaired ROS‐scavenging antioxidants causes oxidative stress . Current researches focus on smart drug delivery systems (SDDSs), gene therapies, and anti‐miRNAs and the exploration of ROS‐scavenging agents with definitive functions to attack mitochondrial ROS .…”

Section: Applicationsmentioning

confidence: 99%

Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives

Maruf

Wang

Yin

et al. 2019

Adv Healthcare Materials

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Atherosclerosis is the root of approximately one‐third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. The assembly of nanoagents with endogenous and exogenous stimuli breaks down their shells, facilitates intracellular delivery, releases their cargo to kill the corrupt cells, and gives imaging reports. All these improvements pave the way toward personalized medicine for atherosclerosis. This review systematically summarizes the recent advances in stimuli‐responsive nanoagents for atherosclerosis management and its progress in clinical trials.

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“…Reactive oxygen species (ROS) are the intermediates generated during the normal metabolic activity, which are effectively neutralized by the antioxidant system of the human body. Any imbalance in this normal metabolism leads ROS to damage cell membranes, enzymes and DNA, which has been one of the major causes of various diseases including neurodegenerative diseases, cancer, and inflammatory condition [2]. Antioxidants are believed to prevent the damage caused by oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Effect of brewing material and various additives on polyphenolic composition and antioxidant bioactivity of commercial Tilia platyphyllos Scop. infusions

Bardakçı¹,

Barak²,

Ozdemir³

et al. 2020

jrp

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Herbal infusions have become very popular due to their pleasant flavor as well as their positive influence on health. The compositions of such infusions are affected by the extraction technique, duration, additives as well as container materials. This study implements comparison of antioxidant activities and phenolic contents of the infusions commercially purchased Tilia platyphyllos Scop. samples, one of the most preferred herbal infusions worldwide, prepared by using teapots with different materials. Antioxidant potencies of the samples were examined using tests with different mechanisms such as free radical scavenging test (DPPH), metal-related activity tests (CUPRAC, FRAP). On account of assessing the phenolic profile, total phenol, phenolic acid and flavonoid contents were estimated spectrophotometrically. In addition, the presence of protocatechuic acid in the extracts was investigated by HPTLC densitometry (between 0.762-1.037 w/w%). Besides, antioxidant activities (DPPH, CUPRAC and TOAC) of the extracts were recalculated after addition of natural/synthetic sweeteners, brown and white sugar, lemon, flower and pine honeys to the infusions. Results showed that the highest total antioxidant capacity was seen on Tiliae infusions prepared in ceramic teapot (672.80±1.40 mg AAE/g DE). Moreover, stevioside addition enhanced DPPH radical scavenging of Tiliae extracts (2781.76±44.38 EC50 in μg/mL). This is the first report related with comparison of these brewing materials and additives in respect to their phenolic content and antioxidant activity of herbal teas.

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Antioxidants: Friend or foe?

Cited by 114 publications

References 59 publications

Efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo en ratones con lesión hepática

Efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo en ratones con lesión hepática

Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives

Effect of brewing material and various additives on polyphenolic composition and antioxidant bioactivity of commercial Tilia platyphyllos Scop. infusions

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