Antioxidants from different citrus peels provide protection against cancer

Abstract

Cancer is one of the leading causes of death. Despite significant advancements in the discovery of medications for the treatment of cancer, these drugs are hindered by applicability and efficacy issues and frequently exhibit major side effects that can further impair patients 'quality of life. Therefore, the development of therapeutically sound anti-cancer medicines derived from natural products has gained prominence in the field of functional foods. Some of these compounds have shown efficacy in the prevention and treatment of cancer as well as low toxicity. Additionally, many recent studies have explored the recycling of agro-industrial waste to create bioactive chemicals. Citrus peels are produced in vast quantities in the food processing sector; due to their abundance of flavonoids, they may be inexpensive sources of protection against several cancers. Citrus is a common type of fruit that contains a variety of nutrients. In particular, the antioxidant chemicals found in citrus peel have been identified as potential cancer-fighting agents. Antioxidant substances such as flavonoids prevent the development of cancer by inhibiting the metastatic cascade, decreasing the mobility of cancer cells in the circulatory system, promoting apoptosis, and suppressing angiogenesis. To explore the most effective uses of citrus peel-derived antioxidants, this review presents background information, an overview of the role of citrus antioxidants in cancer therapy, and a discussion of the key underlying molecular mechanisms.

Anti-Aging Potential of Plants of the Anak Dalam Tribe, Jambi, Indonesia

“…Therefore, there is a demand for natural antioxidant alternatives that are abundantly available in nature. Natural antioxidants work systemically and possess the ability to prevent aging in cells and tissues [ 14 ]. Examples of plants that meet these criteria include those from the Zingiberaceae family, such as C. heyneana and C. longa , which demonstrate antioxidant and anti-aging activities [ 68 , 69 ].…”

“…Long-term use of synthetic antioxidants has been associated with potential carcinogenic effects, whereas natural antioxidants are abundantly available in nature without side effects. Furthermore, natural antioxidants are relatively safer and more cost-effective than synthetic antioxidants [ 14 , 15 , 16 ].…”

Formulation of Antioxidant Gummies Based on Gelatin Enriched with Citrus Fruit Peels Extract

“…However, the citrus industry produces high amounts of waste, accounting for about 50% of the total fruit, mainly peels, seeds, pomace, and wastewaters [5][6][7]. In particular, peels reach 10 million MT each year, representing a heavy environmental burden related to high costs of management [8,9]. Nevertheless, citrus peels can represent a valuable raw material owing to their composition, rich in natural antioxidants, pectin, enzymes, and essential oils using advanced methods [10,11].…”

“…The antioxidant properties of the polyphenols in these extracts counter pathologies linked to excessive reactive species, especially free radicals [9,22,23]. These antioxidants neutralize free radicals, mitigating their harm by forming stable species.…”

Antioxidant Activities and Phytochemical Screening of Ethanol Extract From Surian Leaves (Toona Sinensis)

“…Commonly used synthetic antioxidants include butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and tetrabutyl hydroxyquinone (TBHQ). However, prolonged use of these synthetic antioxidants has side effects as they are considered carcinogenic [6]. Therefore, there is a need for natural antioxidants, abundantly available in nature.…”