Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro

Akintunde, J. K.; Akintunde, Daniel G.; Irondi, Emmanuel Anyachukwu; Babaita, Kehinde; Labaika, Ramat; Sunday, Ojo

doi:10.5455/oams.240516.or.097

Cited by 10 publications

(8 citation statements)

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“…The methanolic stem bark extract scavenged DPPH in a dose-dependent manner with IC 50 = 175 µg/mL. Kigelia africana significantly (p < 0.05) scavenged the DPPH stable radical at IC 50 = 175 µg/mL by 16.75%, 27.57%, 38.28% and 53.2%, respectively, when compared to ascorbic acid [33].…”

Section: Antioxidant Activitymentioning

confidence: 92%

“…Dermatitis-fruit ointment, constipation, gynecological disorders, hemorrhoids, psoriasis, eczema, diarrhea, malaria, rheumatism, retained placenta, dressing for wounds, purgative, galactagogue and dizziness [16,22,25,33,34] Bark Antimicrobial, cytotoxicity and anti-implantation activities [3,22,35,36] Cameroon Stem bark decoction Abortifacient, filariasis and cataract [22] Ghana Bark preparation Dysentery and rheumatism [37] Togo Fruits Cancer [9] Ivory Coast Fruit infusion Rheumatism and back pains [22] Benin, Ivory Coast, and South Africa Leaf decoction Jaundice [6] Nigeria Bark Anti-inflammatory, dysentery and anticancer [5,12,37] Fruits Psoriasis, eczema, leprosy, rheumatism, snakebites, syphilis and chronic abdominal pain [38,39] Root decoction Ante and postnatal disorders, fibroid and conception [6] Fruits and flowers mixed with alcohol or water Fertility treatment among women and men of childbearing age [36] Leaves Diarrhea, abortifacient, aphrodisiac, tonic and impotence [40] Tanzania and Nigeria Hot decoction of stem bark Galactagogue [26] Africa (general)…”

Section: Fruitsmentioning

confidence: 99%

“…Bark decoction Laxative [27] Ash leaves mixed with honey High blood pressure [22] Fruits Mature fruit is used for treating wounds, abscesses, dressing wounds, skin cancer, reducing breast metastasis, ulcers, syphilis, rheumatism, fungal infections, boils, psoriasis, leprosy, venereal diseases and acne [3,14,22,23,27,35,42] Leaves Malaria, rheumatism, wounds, ulcers, retained placenta, venereal diseases and diarrhea [43] Fruit and bark (lesser extent) extracts Dysentery, hemorrhoids, constipation, wounds, ulcers, boils, abscesses, rheumatism, syphilis and gonorrhea [30,33] Fruit and root decoction…”

Section: Fruitsmentioning

confidence: 99%

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Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

Nabatanzi

Nkadimeng

Lall

et al. 2020

Plants

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Kigelia africana has been used in the management of human ailments since time immemorial. Ethnobotanists have documented the traditional uses of K. africana, which include treatment of skin disorders, cancer and gynecological complaints, among others. This has interested scientists, who have examined K. africana plant parts for their bioactivity. This review provides an insightful understanding on the ethnobotany, phytochemistry and pharmacology of K. africana. Web search engines Google and Google Scholar, as well as the databases of PubMed, Scopus, JSTOR, HINARI, SID, AJOL and Springer Link, were exhaustively searched using key words and phrases. Institutional reports and conference papers were also consulted. A total of 125 relevant international literature sources meeting the inclusion criteria were included. Kigelia africana has biologically active phytochemicals, many of which have been isolated. Whilst the fruits are most often cited in pharmacological studies, other plant parts are also used in herbal preparations. Commercially available products have been formulated from K. africana, though many have not been fully standardized. Despite many efforts by researchers to scientifically validate traditional uses of K. africana, many remain merely claims, thus the need to conduct more research, scientifically validate other traditional uses, isolate new bioactive phytochemicals and standardize K. africana products.

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Section: Antioxidant Activitymentioning

confidence: 92%

Section: Fruitsmentioning

confidence: 99%

Section: Fruitsmentioning

confidence: 99%

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Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

Nabatanzi

Nkadimeng

Lall

et al. 2020

Plants

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“…Kigelia africana occurs throughout tropical Africa, particularly in western, central and southern regions. It is widely used in West Africa by the traditional healers as an herbal remedy for the treatment of various ailments [7]. Some studies have highlighted its analgesic, anti-inflammatory and antimicrobial activities [8].…”

Section: Introductionmentioning

confidence: 99%

<i>In Vitro antisickling</i> and Free Radical Scavenging Activities of <i>Kigelia africana</i> (LAM) Stem Bark

Kple¹,

Joël²,

Kra³

et al. 2021

JDMP

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Kigelia africana dried bark has been recommended in the management of sickle cell anemia by traditional practitioners. The aim of this study was to evaluate in vitro antioxidant and sickling inhibitory activities of Kigelia africana. Quantitative estimation of phenolic compounds was performed using colorimetric method in hydro-ethanolic extract (70%) and decocted. The sickling inhibitory activity was determinate according to Emmel method and the evaluation of antioxidant properties was carried out using the method of scavenging the free radical DPPH. The obtained results indicated that Kigelia africana species contains flavonoids (8.61±1.08 mg QE and 9.78±1.14 mg QE/g of dry weight) and total phenols (9.48±0.19b mg GAE/g and 11.11±0.22 mg GAE /g of dry weight) in decocted and hydroethanolic extract respectively. The IC 50 values of the ethanolic extract and the decocted were 0.320±0.01 and 0.468±0.04 mg/mL respectively. The in vitro sickle-formation inhibition test indicated the value of 89% and 82.36% for the ethanolic extract and the decocted at 10mg/mL respectively. Those values were higher than 80% which was the phenylalanine value. Both extracts showed antioxidant and sickling inhibitory activities. Overall, there could have a correlation between these activities and phenolic compound content in this studied plant extracts. These results would justify the use of this plant in rural environment.

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“…K. africana fruits boiled with milk are used in Botswana to treat sexually transmitted diseases; the bark of K. africana is used in Nigeria to treat inflammation, dysentery, and cancer [9,10], and K. africana fruits are used as anti-inflammatories in Kenya, Embu community [11]. Furthermore, antioxidant [12][13][14] and anti-inflammatory studies [15,16] have been conducted on the various parts of K. africana and the species has proven effective. e anti-inflammatory activity of S. campanulata has also been documented and scientifically validated.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti‐Inflammatory Activities of Kigelia africana (Lam.) Benth.

Nabatanzi

Nkadimeng

Lall

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Kigelia africana is used to manage inflammation among indigenous communities. We hypothesized that K. africana extracts contain phytoconstituents with good antioxidant and anti-inflammatory activities. The methanolic extract of K. africana fruits and Spathodea campanulata leaves (SPK04), K. africana aqueous fruit extract (KFM02), and K. africana acetone fruit extract (KFM05) were subjected to antioxidant and anti-inflammatory assays. Antioxidant activity was evaluated using the ABTS radical scavenging assay, and the MTT cell viability assay was used for cytotoxicity. The extracts were preincubated with enzymes and assayed for 15-LOX and COX-2 enzyme activity using an ELISA method. Nitric oxide (NO) inhibitory effect of the extracts was evaluated and measurement of proinflammatory cytokines (IL-1β, TNF-α, and IL-6) and the anti-inflammatory cytokine (IL-10) was done using ELISA kits. SPK04 had the highest antioxidant activity with a mean inhibition of 99.37 ± 0.56% and an IC50 of 4.28 µg/mL. SPK04 and KFM05 did not inhibit 15-LOX as their IC50 values were >1000 μg/mL. All extracts were safe on Vero cells at the highest concentration (200 µg/mL) tested. KFM02 was the best inhibitor of NO production and had the highest cell viability at both the lowest (50 µg/mL) and highest concentrations (200 µg/mL). SPK04 was the best COX-2 inhibitor while KFM05 expressed the strongest suppression effect for IL-β and IL-6. KFM02 did not inhibit IL-6 at the highest concentration (200 µg/mL). The order of suppression of TNF-α by the extracts differed across concentrations, KFM05 > SPK04 > KFM02 at 200 µg/mL, KFM02 > SPK04 > KFM05 at 100 µg/mL, and SPK04 > KFM02 > KFM05 at 50 µg/mL. All the tested extracts had no inhibitory effect against IL-10. SPK04, KFM05, and KFM02 had good antioxidant and anti-inflammatory activity and this supports their use as potential anti-inflammatory therapies. This study presents for the first time the antioxidant and anti-inflammatory activity of K. africana and S. campanulata polyherbal extract. It is also among the very few studies that have reported the inhibitory effect of cytokines IL-1β, TNF-α, IL-6, and IL-10 by K. africana.

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Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro

Cited by 10 publications

References 0 publications

Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

<i>In Vitro antisickling</i> and Free Radical Scavenging Activities of <i>Kigelia africana</i> (LAM) Stem Bark

Antioxidant and Anti‐Inflammatory Activities of Kigelia africana (Lam.) Benth.

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Antioxidants from stem bark of Kigelia africana inhibits free radicals and membrane lipid damage in rat testes in vitro

Cited by 10 publications

References 0 publications

Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae)

&lt;i&gt;In Vitro antisickling&lt;/i&gt; and Free Radical Scavenging Activities of &lt;i&gt;Kigelia africana&lt;/i&gt; (LAM) Stem Bark

Antioxidant and Anti‐Inflammatory Activities of Kigelia africana (Lam.) Benth.

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<i>In Vitro antisickling</i> and Free Radical Scavenging Activities of <i>Kigelia africana</i> (LAM) Stem Bark