Antioxidants in Sepsis

Wilson, John X.

doi:10.1007/978-3-642-30018-9_62

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Immunomodulatory therapies in which patients are prescribed corticosteroids, anti-TNF-αantibodies, anti-interleukin antibodies, platelet-activating factor (PAF) antagonists, antioxidants, as well as the use of selenium modulation of coagulation and complement pathway, have been accepted as beneficial [26, 27, 28, 29, 30, 31, 32], and indeed, some of these strategies proved to be efficacious upon septic patients survival of [33].…”

Section: Personalised Medicine In Sepsismentioning

confidence: 99%

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Lazăr

Georgescu

Vitin

et al. 2019

The Journal of Critical Care Medicine

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In recent years, a new form of medicine has become increasingly significant, namely, personalised medicine (PM). PM is a form of care in which treatment is tailored for an individual patient. PM is about using multiple data sets to create a digital human mapping. A person’s biological traits are determined by the interactions of hundreds of genes and gene networks, as well as external factors such as diet and exercise. Combining and then investigating these multiple databases with powerful statistical tools, allows a new understanding of how genetic intricacy drives health and disease and so leads to a closer personalised medical approach that targets each individual’s unique genetic make-up. Sepsis is a systemic inflammatory response to infection, ranging from systemic inflammatory response syndrome (SIRS) to septic shock and multiple organ dysfunction syndromes (MODS). Sepsis is the most common cause of death in intensive care patients. Treatments in an ICU may need to be adapted to the continuous and rapid changes of the disease, making it challenging to identify a single target. PM is thus seen as the future of sepsis treatment in the ICU. The fact that individual patients respond differently to treatment should be regarded as a starting point in the approach to providing treatment. The disease itself comes secondary to this concept.

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Section: Personalised Medicine In Sepsismentioning

confidence: 99%

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Lazăr

Georgescu

Vitin

et al. 2019

The Journal of Critical Care Medicine

View full text Add to dashboard Cite

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New horizon in the treatment of sepsis: a systematic review of alternative medicine

Mousavi

Ghannadi

Meidani

2016

Journal of Complementary and Integrative Medicine

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BackgroundDespite great advancement in treatment of sepsis, mortality of sepsis remains unacceptably high, even with the modern antibiotic and intensive care technologies. Considering the key role of immune dysfunction in sepsis pathophysiology, different treatments were evaluated, but failed to improve survival of patients. Natural remedies have been tested in various studies to overcome sepsis. In this study, we aim to review some of the evidence from clinical, in vitro and in vivo studies about the effect of alternative medicine on sepsis management. MethodsThe following databases were searched up to March 2014: PubMed, Scopus, Web of Science, Ovid and Google Scholar using combination of Mesh term. All in vitro and in vivo studies, also clinical trials, published in English, which evaluated alternative medicine in management of sepsis were included. Results Out of 95 relevant studies, the inclusion criteria were met for 79 cases. Among them, 18 studies were performed on humans. The most herbal medicine, including Xubijing (n=10) and then Rhubarb (n=3). Most of the reviewed botanical medicines modulate the immune system. Reduction of mortality was also reported in studies. ConclusionsModulation of immune system, anti-inflammatory activities and improvement of survival were the action of herbal medicine. A monovalent approach is not enough for treatment of sepsis, we recommend further studies to identify active component of herbal and use them in combination. Also an animal model of sepsis does not exactly mimic human sepsis, so more clinical studies should be performed. With no new drug on the horizon, herbal medicine will be promising for treatment of sepsis.

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Antioxidants in Sepsis

Cited by 2 publications

References 61 publications

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

Precision Medicine and its Role in the Treatment of Sepsis: A Personalised View

New horizon in the treatment of sepsis: a systematic review of alternative medicine

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