Antioxidants: The good, the bad and the ugly

Tardif, Jean‐Claude

doi:10.1016/s0828-282x(06)70988-6

Cited by 21 publications

(14 citation statements)

References 54 publications

(46 reference statements)

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“…Nevertheless, the in vivo relevance of oxidative processes in atherosclerosis remains speculative. Several well-powered human clinical trials of antioxidant vitamins, such as vitamin E and vitamin C, have failed to show a reduction of cardiovascular events 35 , pushing the field to consider alternative bases for foam cell formation.…”

Section: Foam Cell Formation In Atherosclerosismentioning

confidence: 99%

Macrophages in atherosclerosis: a dynamic balance

2013

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Preface Atherosclerosis is a chronic inflammatory disease arising from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall. Through the analysis of animal models of atherosclerosis progression and regression, there is a growing understanding that the balance of macrophages in the plaque is dynamic, with both macrophage numbers and an inflammatory phenotype influencing plaque fate. Here we summarize recently identified pro- and anti-inflammatory pathways linking lipid and inflammation biology with the retention of macrophages in plaques, as well as factors with the potential to promote their egress from these sites.

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Section: Foam Cell Formation In Atherosclerosismentioning

confidence: 99%

Macrophages in atherosclerosis: a dynamic balance

2013

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“…This study was designed to investigate possible effects of ionic high-osmolar contrast medium in liver, bladder, and ovary tissues from rats. Antioxidants combat with free radicals, thus, preventing oxidative damage in tissues (Gey, 1990;Tardif, 2006). Some studies suggested that consumption of vitamin C-rich foods, such as fruits and vegetables, reduces oxidative damage (Block et al, 2001;Joshipura et al, 2001;Liu et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective role

et al. 2009

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High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective roleAbstract The purpose of this study was to investigate effects of ionic highosmolar contrast medium on oxidative metabolism in liver, urinary bladder, and ovary tissues and to obtain information about possible protective effects of vitamin C. Twenty-one female rats, 14 weeks old, were used in this study. They were divided into three groups of seven rats: Sham (group I), contrast (group II), contrast ? vitamin C (group III). Vitamin C was given orally to the animals in group III during the study period. On the fifth day, contrast medium was given via intravenous infusion as a single dose to the animals in groups II and III. On the sixth day of the study, the animals were killed with anesthesia by ketamine hydrochloride. Then, their liver, bladder, and ovary tissues were removed to measure analyses parameters. Our results suggested that contrast medium led to some increases in malondialdehyde levels in the liver, bladder, and ovary tissues and that vitamin C prevented these increases in the tissues. Nitric oxide level also was found to increase in the contrast-treated animals and vitamin C prevented this increase in the liver tissue. MEDICINAL CHEMISTRY RESEARCHIonic high-osmolar contrast medium leads to weak oxidant stress in rat liver, bladder, and ovary tissues, and vitamin C prevents this oxidant stress.

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“…The mitochondria, the cellular membrane oxidases, such as NADPH oxidase, nitric oxide synthase and myeloperoxidase are major sources of ROS. The byproducts associated with the metabolism of arachidonic acid by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase also result in the production of ROS [238]. The ROS produced in the body include superoxide (O 2 − ), hydroxyl (OH − ), hydroperoxyl (HOO − ), peroxyl (ROO − ), and alkoxyl (RO − ) radicals, and the reactive nitrogen species (RNS) include nitric oxide (NO − ) and the peroxynitrite anion (ONOO − ) [231].…”

Section: Molecular Targets For Natural Chemopreventive Agentsmentioning

confidence: 99%

Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

Pratheeshkumar

Sreekala²,

Zhang³

et al. 2012

ACAMC

152

100

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Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.

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Antioxidants: The good, the bad and the ugly

Cited by 21 publications

References 54 publications

Macrophages in atherosclerosis: a dynamic balance

Macrophages in atherosclerosis: a dynamic balance

High osmolar contrast medium causes mild oxidation in liver, bladder, and ovary tissues from rats: vitamin C has protective role

Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

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