Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High‐Cholesterol Diet

Zhang, Guangyin; Li, Ming; Xu, Yinzhi; Li, Peng; Yang, Chunrong; Zhou, Yanan; Zhang, Junping

doi:10.1155/2016/6929306

Cited by 9 publications

(9 citation statements)

References 46 publications

(51 reference statements)

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“…The HFD administered to our rabbits enhances lipid oxidation. This is indicated by MDA rise according to Yu et al [ 55 ], Zhang et al [ 65 ], Sethi et al [ 63 ], Apaijai et al [ 66 ], and Pipatpiboon et al [ 67 ]. It also minimizes the total antioxidant protection by AOA and ascorbic acid level reduction as in the study of Moor de Burgos et al [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits

Sibouakaz

Othmani-Mecif

Fernane

et al. 2018

Analytical Cellular Pathology

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Early weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. Experiments were carried on 24 prepubertal New Zealand white rabbits, randomly assigned to male and female control (MC and FC, resp.) or HFD (MHFD and FHFD, resp.) groups (n = 6) for 3 months. Body and heart weights and some biochemical and oxidative stress parameters such as lipids, calcium, CKMB, MDA, uric acid, ascorbic acid, and AOA are evaluated in plasma and the left ventricle. Under HFD effect, plasma parameters, such as lipids (TL, PL, and LDL-C), MDA, and CK-MB, increase more significantly in male than in female groups, when AA decreases. Some cardiac parameters such as TG and UA increase, when AA and AOA decrease; these variations are more significant in FHFD. In both male and female rabbits, HFD caused changes in heart ultrastructure, junctional complexes, mitochondria size and form, and so on. Early HFD feeding induced overweight, oxidative stress, and metabolic alterations in plasma and the heart of prepubertal rabbits, whereas lipotoxicity has especially a negative impact on male plasma but affects more the female heart ultrastructure.

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Section: Discussionmentioning

confidence: 99%

Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits

Sibouakaz

Othmani-Mecif

Fernane

et al. 2018

Analytical Cellular Pathology

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“…Atherosclerotic cardiovascular disease is a major cause of morbidity and mortality worldwide [1]. Hypercholesterolaemia has been shown to be a major risk factor for atherosclerosis, associated with increasing oxidative stress and impaired endothelial function [2, 3]. The normal endothelium plays an important role in maintaining vascular homeostasis and regulating basal vascular tone through the production of several vasoactive substances, including nitric oxide (NO) and endothelin [4].…”

Section: Introductionmentioning

confidence: 99%

Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression

Pengnet

Prommaouan

Sumarithum

et al. 2019

BioMed Research International

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Hypercholesterolaemia is associated with oxidative stress and endothelial dysfunction and leads to the development of atherosclerosis. Naringin exhibits cardiovascular protective and antioxidant properties. Therefore, the aim of this study was to assess the effect of naringin administration on vascular oxidative stress and endothelial dysfunction in hypercholesterolaemic rats and to elucidate its underlying mechanism. Sprague Dawley rats were fed a diet with 1.5% cholesterol (HCD) for 8 weeks to induce hypercholesterolaemia. Naringin (100 mg/kg body weight) was orally administrated to rats during the last 4 weeks of the diet treatment. After 8 weeks, the thoracic aorta was isolated to determine vascular function and nitric oxide (NO) levels. The aortic superoxide anion (O2−) level was detected using dihydroethidium (DHE) fluorescence staining. Protein expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits, and inducible nitric oxide synthase (iNOS), as well as oxidative damage markers, was also evaluated in aortae. Naringin treatment of hypercholesterolaemic rats enhanced aortic NO levels, restored endothelium-dependent responses to acetylcholine (ACh), and reduced aortic O2− levels. Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats. These results demonstrate that naringin treatment improves endothelium dysfunction in hypercholesterolaemic rats, at least partially by decreasing oxidative stress via downregulation of LOX-1 and NADPH oxidase.

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“…The previous data reported that that simvastatin improved the antioxidant status via prevention of oxidative stress 56 . Also, Zhang et al 2016 57 indicated statins reversed the increase in lipid peroxidation the decrease in GSH-Px expression in the hippocampus hypercholesterolemic rabbits compared to the control group. Moreinga oleifera extract has been shown to decrease immobility duration, as well as a reduction in blood MDA 58 .…”

Section: Discussionmentioning

confidence: 98%

The Potential of Moringa oleifera to Induce Cerebral Leptin mRNA Expression and to Attenuate Oxidative Stress, Cognitive and Motor Deficits, Depression- and Anxiety- Like Behavior in Experimental Obese Model

Mahmoud¹,

Metwally²,

Rashad³

et al. 2017

IJPCR

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Moringa oleifera showed an evident role against obesity and leptin resistance. However, Moringa oleifera potential effects on alteration of moods, cognitive as well as motor deficits in obese animal model have not been evaluated in a mechanistic way. So, the aim of the current study is to examine the potential of Moringa oleifera to induce cerebral leptin mRNA expression, and consequently its effects on amelioration of behavioral and biochemical alterations in obese female rats. Ethanolic extract of Moringa oleifera was orally administered (600 mg/kg b.wt) for 12 weeks to those obese rats. Memory behavior, depression- and anxiety-like behavior, as well as motor activity were examined by object recognition test, forced swim test, light and dark test, and open field test, respectively. Leptin mRNA gene expression and its concentration were determined in cerebral cortex using quantitative real time-PCR and ELISA, respectively. Oxidative stress markers malondialdehyde and glutathione were also evaluated in the cerebral cortex. Moringa oleifera significantly up-regulated cerebral leptin mRNA expression and its level, as well compared to control obese rats. Moreover, Moringa oleifera decreased lipid peroxidation significantly, whereas they improved glutathione significantly in comparison with those untreated rats. Regarding behavioral deficits, Moringa oleifera attenuated the declined memory, depression and anxietylike behavior, as well as the motor deficit that observed in obese untreated rats. This study indicated the potential of Moringa oleifera in triggering cerebral leptin mRNA expression, hence protection of brain from oxidative damage as well as improvement of cognition, moods and motor deficits in obese rats.

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Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High‐Cholesterol Diet

Cited by 9 publications

References 46 publications

Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits

Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits

Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression

The Potential of Moringa oleifera to Induce Cerebral Leptin mRNA Expression and to Attenuate Oxidative Stress, Cognitive and Motor Deficits, Depression- and Anxiety- Like Behavior in Experimental Obese Model

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