Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark of<i>Juglans mandshurica</i>

Ngoc, Tran Minh; Hung, Tran Manh; Thương, Phương Thiện; Kim, Jin-Cheon; Choi, Jae Sue; Bae, KiHwan; Hattori, Masao; Choi, Chul-Hee; Lee, Joon Seok; Min, Byung‐Sun

doi:10.1271/bbb.80222

Cited by 41 publications

(16 citation statements)

References 25 publications

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“…Compounds 7 , 8 , 9 , 10, and 12 were identified as galloyl monosaccharides, which resulted from esterification of glucose by 3–5 GA units (galloyl, m/z 170). Interestingly, it has been shown that the number of galloyl units determine antioxidant capacity of galloylglucose isomers ( Ngoc et al, 2008 ). Peaks 11 , 13 , 14, and 15 were tentatively identified as myricetin-derived compounds ( Gordon et al, 2011 ).…”

Section: Resultsmentioning

confidence: 99%

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

et al. 2016

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Syzygium cumini (L.) Skeels (Myrtaceae) has been traditionally used to treat a number of illnesses. Ethnopharmacological studies have particularly addressed antidiabetic and metabolic-related effects of extracts prepared from its different parts, especially seed, and pulp-fruit, however. there is a lack of studies on phytochemical profile and biological properties of its leaf. As there is considerable interest in bioactive compounds to treat metabolic syndrome and its clustered risk factors, we sought to characterize the metabolic effects of hydroethanolic extract of S. cumini leaf (HESc) on lean and monosodium L-glutamate (MSG)-induced obese rats. HPLC-MS/MS characterization of the HESc polyphenolic profile, at 254 nm, identified 15 compounds pertaining to hydrolysable tannin and flavanol subclasses. At 60 days of age, both groups were randomly assigned to receive HESc (500 mg/kg) or vehicle for 30 days. At the end of treatment, obese+HESc exhibited significantly lower body weight gain, body mass index, and white adipose tissue mass, compared to obese rats receiving vehicle. Obese rats treated with HESc showed a twofold increase in lipolytic activity in the periepididymal fat pad, as well as, brought triglyceride levels in serum, liver and skeletal muscle back to levels close those found in lean animals. Furthermore, HESc also improved hyperinsulinemia and insulin resistance in obese+HESc rats, which resulted in partial reversal of glucose intolerance, as compared to obese rats. HESc had no effect in lean rats. Assessment of ex vivo glucose-stimulated insulin secretion showed HESc potentiated pancreatic function in islets isolated from both lean and obese rats treated with HESc. In addition, HESc (10-1000 µg/mL) increased glucose stimulated insulin Syzygium cumini Dual Effect in MSG-Obese Rats secretion from both isolated rat islets and INS-1E β-cells. These data demonstrate that S. cumini leaf improved peripheral insulin sensitivity via stimulating/modulating β-cell insulin release, which was associated with improvements in metabolic outcomes in MSG-induced obese rats.

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Section: Resultsmentioning

confidence: 99%

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

et al. 2016

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“…They have many health‐beneficial effects that have been attributed to the antioxidant activity of the phenolics 40. As gallic acid is considered one of the most important bioactive compounds influencing the antioxidant activity in plant tissue,41 frequent consumption of hazelnut kernels can be recommended. Respecting the amount of gallic acid and (−)‐epicatechin, the cultivars TGDL, Daria, ID, F. Coutard, Romai and Morell may be favoured.…”

Section: Resultsmentioning

confidence: 99%

Characterisation of selected hazelnut cultivars: phenology, growing and yielding capacity, market quality and nutraceutical value

Solar

Štampar

2011

J Sci Food Agric

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“…Nineteen diarylheptanoids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) have been found in Juglans, including 11 cyclic-and 8 linear-diarylheptanoids. The cyclicdiarylheptanoids are divided into two types, based on the connection of the two benzene rings.…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Antioxidant activity: Research has shown that walnuts possess greater antioxidant activities than any other nuts [98]. The other parts of Juglans also exhibit the ability to scavenge free radicals, such as green husk, stem bark, and leaves [16,18]. The majority of this antioxidant activity can be accredited to the polyphenols.…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…These plants mainly contain diarylheptanoids, juglone and its derivatives, polyphenols, flavones and terpenes [11][12][13][14][15]. The pharmacological activities of these chemical constituents have been primarily focused on antitumor [2], antioxidant [16][17][18] and antibacterial activities [19]. With the rising need for new cancer treatments, these Juglans species have become of great interest for their anticancer value [20][21][22][23].…”

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confidence: 99%

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Phytochemistry, Bioactivity and Potential Impact on Health of Juglans: the Original Plant of Walnut

Zhao

Jiang

et al. 2016

Natural Product Communications

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Walnuts can nourish brain cells to improve human memory. Other parts of the plant are also employed as traditional Chinese medicines. Modern research on Juglans species has been mostly focused on the above-mentioned species, the seeds of which are all called walnuts. Juglans species have diverse chemical constituents, including diarylheptanoids, quinones, polyphenols, flavones and terpenes. The diarylheptanoids and quinones have notable antitumor activity, supplying new lead compounds for preparing antitumor drugs. The potent pain-relieving, antioxidant, antibacterial and antitumor activities of these plants are significant. In the review, comprehensive information on the nutritional characteristics, traditional functions, chemical constituents, and biological activities of the Juglans species, together with the seeds used as walnuts is provided to explore their potential and to advance research.

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Antioxidative Activities of Galloyl Glucopyranosides from the Stem-Bark ofJuglans mandshurica

Cited by 41 publications

References 25 publications

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

Characterisation of selected hazelnut cultivars: phenology, growing and yielding capacity, market quality and nutraceutical value

Phytochemistry, Bioactivity and Potential Impact on Health of Juglans: the Original Plant of Walnut

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