Antioxidative Activities of Medicinal Plants from TCM

Liu, Qi-Mei; Jiang, Jian-Guo

doi:10.2174/138955712802762239

Cited by 26 publications

(15 citation statements)

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“…Therefore, the Yangjing capsule extract can exert a protective effect on Leydig cells in vitro . It is reported that polysaccharides exert antiapoptosis and antioxidative activities [28, 29]. It has been demonstrated that Rhizoma Polygonati Sibirici polysaccharides were able to prevent apoptosis in hypoxic neurons through upregulation of Bcl-2 protein expression, downregulation of Bax-2 protein expression and raising the ratio of Bcl-2/Bax [30].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells

Sun

Cui²,

Jin³

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Objectives. This study aimed to explore the effect and mechanism of Yangjing capsule on testosterone secretion in mouse Leydig tumor cells (MLTC-1). Methods. MLTC-1 cells were treated with the Yangjing capsule extract for 24 h. The testosterone level in medium was measured by radioimmunoassay. The expression of steroidogenic enzymes (StAR, CYP11A1, and HSD3B) in the cells was examined using real-time RT-PCR and immunoblotting. Additionally, MLTC-1 cells were treated for 48 h in a serum-free medium. The cell viability was measured by MTT assay. The cell cycle and apoptosis were analyzed using flow cytometry. The expression of activated caspase-3 was analyzed using RT-PCR and a colorimetric protease assay. Results. The Yangjing capsule extract increased testosterone production and the expression of StAR, CYP11A1, and HSD3B mRNAs and proteins compared with the control. H89 significantly inhibited these effects. The medicine improved the viability of MLTC-1 cells, decreased the number of cells in G0/G1 phase, and increased the number of cells in S-phase, as well as prevented cell apoptosis by inhibiting caspase-3. Conclusion. The Yangjing capsule can stimulate MLTC-1 cells to secrete testosterone and may be an alternative treatment for diseases characterized by insufficient testosterone production.

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Section: Discussionmentioning

confidence: 99%

Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells

Sun

Cui²,

Jin³

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Many chronic degenerative diseases and cancer have a direct or indirect relationship with the damaging effects of free radicals (Bielli, Scioli, Mazzaglia, Doldo, & Orlandi, 2015). Medicines possessing antioxidant activity can reduce oxidative stress injury caused by free radicals (Hong, Hu, Liu, Zhou, & Zhao, 2014;Liu & Jiang, 2012;Zhou, Tang, Keep, Ma, & Xiang, 2014). Many components of S. miltiorrhiza Bge.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating

Fan

Wang

et al. 2018

Biomedical Chromatography

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Salvia miltiorrhiza Bge. is a traditional Chinese medicine applied in the treatment of various diseases in clinical practice. In the course of its processing, S. miltiorrhiza Bge. is usually processed by sweating. This study employed 10-component contents determination coupled with high-performance liquid chromatography (HPLC) fingerprint and antioxidant activity to investigate the effect of sweating on S. miltiorrhiza Bge. so as to evaluate the quality of S. miltiorrhiza Bge. The HPLC method was performed using C and 0.05% phosphoric acid aqueous solution-acetonitrile with a gradient elution system. It was validated for linearity, precision, repeatability, stability and recovery. Similarity analysis, principal components analysis and antioxidant activity assays were used to compare sweated S. miltiorrhiza Bge. (SSM) and nonsweated S. miltiorrhiza Bge. (NSSM). SSM and NSSM showed good similarities in HPLC fingerprint (>0.9), but principal components analysis could classify the HPLC fingerprint and 10-component quantitation analysis. Meanwhile, the antioxidant activity of SSM was significantly higher than that of NSSM (p < 0.01). The results of this study indicated that sweating could alter the content of chemical constituents in S. miltiorrhiza Bge., and could also improve its antioxidant activity. In addition, the method not only affords a viable strategy for comparing SSM and NSSM and assessing the quality of S. miltiorrhiza Bge., but also provides a reference for other herbal medicine that suffers from sweating.

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“…The studies on antioxidant activity of plants have increased dramatically in recent years, because they are identified as natural antioxidant resources by traditional Chinese medicine [1]. Medicinal plants have usually been applied to control the blood glucose or reduce the diabetic complications; they have the potential to increase the life span and quality of life in these patients [2].…”

Section: Introductionmentioning

confidence: 99%

Determination of Polar Compounds in Guava Leaves Infusions and Ultrasound Aqueous Extract by HPLC-ESI-MS

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2015

Journal of Chemistry

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Literature lacks publications about polar compounds content in infusion or guava leaves tea. Because of that, a comparison between different times of infusion and a conventional ultrasound aqueous extract was carried out. Several polar compounds have been identified by HPLC-ESI-MS and their antioxidant activity was evaluated by FRAP and ABTS assays. Four different classes of phenolic compounds (gallic and ellagic acid derivatives, flavonols, flavanones, and flavan-3-ols) and some benzophenones were determined. The quantification results reported that the order, in terms of concentration of the classes of polar compounds in all samples, was flavonols > flavan-3-ols > gallic and ellagic acid derivatives > benzophenones > flavanones. As expected, the aqueous extract obtained by sonication showed the highest content in the compounds studied. Significative differences were noticed about the different times of infusion and five minutes was the optimal time to obtain the highest content in polar compounds using this culinary method. All the identified compounds, except HHDP isomers and naringenin, were positively correlated with antioxidant activity.

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Antioxidative Activities of Medicinal Plants from TCM

Cited by 26 publications

References 0 publications

Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells

Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells

Comparison of the chromatographic fingerprint, multicomponent quantitation and antioxidant activity of Salvia miltiorrhiza Bge. between sweating and nonsweating

Determination of Polar Compounds in Guava Leaves Infusions and Ultrasound Aqueous Extract by HPLC-ESI-MS

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