Antioxidative activities of some chemotherapeutics. A possible mechanism in reducing gingival inflammation

Abstract

Inflammatory periodontal diseases are related to dental plaque formation. Increase in the perfusion of the inflamed tissue results in increased oxygen supply. Although oxygen has healing effects, it is bound to be a mediator of peroxidation in biological membranes. Chemotherapeutic agents such as chlorhexidine, listerine, sanguinarine, and cetylpridinium chloride and oral antibiotics such as tetracycline HCl and doxycyline were tested for their antioxidative activities. While doxycycline has the highest antioxidant activity in lower volumes (0.1 ml), sanguinarine, listerine and a pace after them, tetracycline HCl, had similar effects in higher volumes (0.3 and 0.4 ml). The results showed that in addition to their antiseptic or antimicrobial effects, these preparations have an antioxidative activity against spontaneous oxidation.

Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells—Nuclear vs. mitochondrial effects

“…One possible explanation for this behaviour would be that SANG would decrease mitochondrial DC for the highest concentrations, thus decreasing calcium entry and hence pore opening but measurements of DC using a TPP-selective electrode excluded this hypothesis. Another likely explanation is that SANG can act as an antioxidant [52,53], effective for the highest concentrations tested, thus inhibiting pore opening by reducing the amount of oxidized thiol groups in the pore complex [54]. The differential activity of SANG on calcium loading capacity (Fig.…”

Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation

“…In human peripheral blood neutrophils, sanguinarine has been shown to inhibit PMA-induced oxidative bursts and generation of superoxide anions (5,17). Also, sanguinarine has been shown to have antioxidative activity against spontaneous oxidation (40). Therefore, it is possible that sanguinarine suppresses NF-B activation by inhibiting reactive oxygen intermediate generation.…”

“…Sanguinarine exhibits antimicrobial, anti-inflammatory, and antioxidant properties (5,(11)(12)(13)(14)(15)(16)(17). Since anti-inflammatory compounds like aspirin and glucocorticoid have been shown to inhibit activation of NF-B (18 -20), we investigated the effect of sanguinarine on activation of NF-B induced by a wide variety of agents including TNF.…”

Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

“…For example, some papers claimed, for chlorhexidine, an anti-oxidant but still partially unclear role in its molecular mechanism (Goultschin and Levy, 1986;Firatli et al, 1994); however, chlorhexidine and salicylic acid reduce 02.-produced by PMN (Shapira et al, 1997).…”