Antioxidative Activity of Carbazoles from<i>Murraya koenigii</i>Leaves

Tachibana, Yukari; Kikuzaki, Hiroe; Lajis, Nordin Hj; Nakatani, Nobuji

doi:10.1021/jf010621r

Cited by 251 publications

(165 citation statements)

References 18 publications

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“…Antioxidant carbazoles have been reported present in MKL may be favorably contributing to the memory enhancing effect seen in the present study. Thus, the protective effect of MKL may be attributed to its antioxidant property by virtue of which susceptible brain cells get exposed to less oxidative stress resulting in reduced brain damage and improved neuronal function (Chakrabarty et al, 1997;Ramsewak et al, 1999;Tachibana et al, 2001;Wang et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Leaf extract of Murraya koenigii have also been reported to posses antifungal, antineoplastic, nitric oxide scavenging and antioxidant activities (Das et al, 1965;Khan et al, 1996a;Chakrabarty et al, 1997;Khan et al, 1997;Ramsewak, et al, 1999;Tachibana et al, 2001;Baliga et al, 2003). Anti-oxidant, Antitumor, Anti-microbial and Anti-diabetic actives have been reported for some carbazole alkaloids, which were identified as the major compounds in Murraya koenigii leaves (Tachibana et al, 2001;Adebajo et al, 2004Adebajo et al, , 2006Ito et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYMurraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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“…Phytochemical studies on leaves, stem, bark and root of this plant have resulted in the isolation of carbazole alkaloids including murrayanine, girinimbine, mahanimbine, murrayafoline-A and one triterpene (Chakraborty et al 1978;Ito et al 1993;Baker et al 2007). Five more carbazole alkaloids viz, euchrestine B, bismurrayafoline E, mahanine, mahanimbicine and mahanimbine were reported from curry leaves and their radical RSA were ascertained (Tachibana et al 2001). This species is known to possess anti-inflammatory, antidysenteric, antioxidant, antidiabetic and has diverse pharmacological properties (Arulselvan and Subramanian 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of temperature and solvent on antioxidant properties of curry leaf (Murraya koenigii L.)

Sasidharan

Menon

2010

J Food Sci Technol

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Total polyphenol content (TPC) and antioxidant activities of curry leaf extracts (hexane, chloroform, ethanol, ethanol-water (1:1) and water at ambient (AT, 25°C) and boiling temperature (BT) (Soxhlet extraction), were determined by DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt), and total reductive potential assays. TPC was in the order ethanol-water (1:1) (AT) > water (AT) > chloroform (AT) > ethanol-water (1:1) (BT) > hexane (AT) > ethanol (BT) > water (BT) > hexane (BT). Ethanol-water (AT) had the maximum TPC of 501± 4.6 mg/g GAE and 82% radical scavenging activity (RSA) at 10 μg/ml level (DPPH) and 100% RSA (ABTS) at 10 μg/ml and at hot conditions (ethanol-water (BT)) had less TPC (28.7±0.9%), and 43% RSA by DPPH and 53.6% by ABTS assays. Hot extracts had lesser antioxidant activities than ambient extracts. The best solvent system for getting maximum antioxidant activity from curry leaves was ethanol-water (1:1)-(AT).

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“…which exhibit good anti-oxidant activity. 8 Based on their order of potency in exhibiting anti-oxidant activity, well known carbazoles of M. koenigii have demonstrated activity based on their structural aspects in following order: mahanine > bismahanine > isomahanine > euchrestine B > bispyrayafoline > bismurrayafoline > koenimbine > O-methylmahanine > O-methylmurrayamine A > mahaninebicine > mahaninebine. 9 Numerous hybridized carbazole moieties have been reported that possess high anti-oxidant activity as compared to some substituted carbazoles.…”

Section: Introductionmentioning

confidence: 99%

Schiff’s base derivatives of murrayanine demonstrated enhanced anti-oxidant activity than its parent moiety

Shivhare¹,

Mahapatra²,

Nair³

et al. 2016

IJPER

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Objective: Free radicals like superoxide anion radical (O 2 .-), hydroxyl radical (HO.), alkyl radical (R.), alkoxy radical (RO.), peroxy radical (ROO.) and nitric oxide radical (NO.) often leads to oncogenic proliferation, damage deoxyribosyl backbone of DNA, accelerate oxidation of polydesaturated fatty acids, amino acids, and several other co-factors. Several carbazole moieties present in M. koenigii L. like murrayanine, mahanimbine, curryanine, kurryam have been reported to exhibit good anti-oxidant activity. The present research represents an effort to develop few novel hybridized derivatives of murrayanine (an active carbazole derivative) by reacting with various small ligands like urea, semi carbazide and thio semi carbazide with an intention to develop Schiff's base compounds with higher and potent anti-oxidant activity than its parent moiety (murrayanine). Methods: The study protocol involved DPPH radical scavenging assay and determining in vitro reducing activity of the semi-synthetic derivatives. Results: The study revealed that compound 5 exhibited highest anti-oxidant activity (IC 50 of 6.5 μM), followed by derivative 3 which displayed activity at IC 50 value of 7.3 μM, which was superior as compared to murrayanine 1 which scavenge the radical at IC 50 of 7.6 μM. However, two semi-synthetic compounds (2 and 4) exhibited lesser activity compared to murrayanine, IC 50 s of 7.8 and 8.1μM, respectively. The compounds exhibited absorbance in range 0.76-1.3. Highest absorbance of 1.079 was demonstrated by 5. Conclusion: This study can be concluded that these derivatives may have enough potential to be used as antioxidants and open new doors for research perspectives towards the development of novel radical scavenging moiety.

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Antioxidative Activity of Carbazoles fromMurraya koenigiiLeaves

Cited by 251 publications

References 18 publications

Nootropic Potential of Murraya koenigii leaves in Rats

Nootropic Potential of Murraya koenigii leaves in Rats

Effects of temperature and solvent on antioxidant properties of curry leaf (Murraya koenigii L.)

Schiff’s base derivatives of murrayanine demonstrated enhanced anti-oxidant activity than its parent moiety

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