Antioxidative activity of the crude extract of lignan glycosides from unroasted Burma black sesame meal

Shyu, Yung-Shin; Hwang, Lucy Sun

doi:10.1016/s0963-9969(01)00130-2

Cited by 182 publications

(100 citation statements)

References 18 publications

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“…The antioxidant activity of fruits, herbs and vegetables from organic and conventional farming was measured by means of free radical DPPH (2,2-diphenyl-1-picryhydrazyl) as previously reported by Brand-Williams et al (1995) and Shyu and Hwang (2002) with some modifications. This method is based on the reduction of the stable DPPH radical (2,2-dipenyl-1-picrylhydazyl) in to DPPH 2 .…”

Section: Determination Of Antioxidant Activitymentioning

confidence: 99%

Antioxidant activity in selected Slovenian organic and conventional crops

Knap

Ogrinc

Potočnik

et al. 2015

AAS

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The demand for organically produced food is increasing. There is widespread belief that organic food is substantially healthier and safer than conventional food. According to literature organic food is free of phytopharmaceutical residues, contain less nitrates and more antioxidants. The aim of the present study was to verify if there are any differences in the antioxidant activity between selected Slovenian organic and conventional crops. Method of DPPH (2,2-diphenyl-1-picryhydrazyl) was used to determine the antioxidant activity of 16 samples from organic and conventional farms. The same varieties of crops were analysed. DPPH method was employed to measure the antioxidant activity of polar antioxidants (AA p ) and antioxidant activity of fraction in ethyl acetate soluble antioxidants (EA AA). Descriptive statistics and variance analysis were used to describe differences between farming systems. Estimated differences between interactions for the same crop and different farming practice were mostly not statistically significant except for the AA p for basil and beetroot. Higher statistically significant values were estimated for conventional crops. For the EA AA in broccoli, cucumber, rocket and cherry statistically significant higher values were estimated for organic production.

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Section: Determination Of Antioxidant Activitymentioning

confidence: 99%

Antioxidant activity in selected Slovenian organic and conventional crops

Knap

Ogrinc

Potočnik

et al. 2015

AAS

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“…14) These compounds also scavenge peroxyradicals in in vitro experimental systems. [15][16][17] Kang et al 18) have reported that defatted sesame flour containing SG inhibits lipid peroxidation in hypercholesterolemic rabbits. We also observed that SG had a protective effect against Ab induced neuronal cell death 19) and showed an inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory response in astrocytes.…”

Section: )mentioning

confidence: 99%

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Ahn

Kim

et al. 2009

Biological & Pharmaceutical Bulletin

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Alzheimer's disease (AD) is characterized by progressive cognitive function deficits due to the presence of numerous senile plaques and neurofibrillary tangles in certain brain regions.1) The main component of senile plaques is b-amyloid peptide (Ab), which is derived from a large amyloid precursor protein (APP).2) Ab 25-35 contains the residues important for aggregation and toxicity including methionine 35.3) This amyloid fragment has been shown to induce neurotoxicity in vitro as well as in vivo. 4,5) In addition, the intracerebroventricular (i.c.v.) administration of Ab 25-35 into rodent brain induced histological change and cognitive deficit.6,7) The deposition of Ab may cause neuronal death via a number of possible mechanisms including oxidative stress and inflammatory response, which has been suggested to play a key role in AD pathogenesis. 2)Oxidative stress has been hypothesized to play a pivotal role in excitotoxicity, inflammation, and apoptosis in the AD brain. Marker of oxidative stress such as lipid peroxides, protein carbonyl groups, and 8-hydroxyl-2Ј-deoxyguanosine (8-OHdG) are increased in the brains of AD patients than in aged-matched control brains. 8,9) Moreover, it has been reported that Ab induces neurotoxicity via oxidative stress, and some antioxidants, such as vitamin E and ferulic acid, protect neurons from Ab-induced apoptosis. 4,10,11) Therefore, the attenuation of oxidative stress through antioxidant therapies may be useful in the treatment/prevention of AD. 12)Sesame (Sesamum indicum LINN.) is widely known as a natural healthy food, and contains sesame lignan and lignan glycosides.13) Sesame lignan compounds, including sesamin gludosides (SG), have been shown to inhibit endogenous lipid peroxidation as well as oxidative DNA damage in rat liver and kidney.14) These compounds also scavenge peroxyradicals in in vitro experimental systems. [15][16][17] Kang et al. 18) have reported that defatted sesame flour containing SG inhibits lipid peroxidation in hypercholesterolemic rabbits. We also observed that SG had a protective effect against Ab induced neuronal cell death 19) and showed an inhibitory effect on lipopolysaccharide (LPS)-induced inflammatory response in astrocytes. 20) Taking those facts into account, we hypothesized that SG exerts a neuroprotective effect in AD.Since the effect of SG on cognitive function has not been reported, we investigated whether SG can exhibit the protective effect on the Ab 25-35 -induced cognitive impairments. MATERIALS AND METHODSSample Preparation SG isolated form sesame seed was prepared according to the method described by Katsuzaki et al.13) Deffated sesame flour was extracted with distilled water at 95°C for 1 h to obtain a crude extract containing sesaminol glucosides. Crude SG was further purified by Diaion HP 20 (Mitsubishi Chemicals, Co., Tokyo, Japan) column using 60% ethanol. The extracts were concentrated under reduced pressure and freeze-dried for storage until use. Total SG content of the extract was determined by UV spectroscopy, and th...

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“…Sesame seeds contain up to 55% oil (rich in linoleic and oleic acids) and 20% protein (limited by lysine but rich in tryptophan and methionine) [44,45]. Similar results were found by Nzikou, et al (2009) [42] who reported that sesamum indicum L. seed oil is of unsaturated type and contains mainly the fatty acids oleic C18:1(38.84 %) and linoleic C18:2 (46.26%).…”

Section: Resultsmentioning

confidence: 53%

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

Rabeh¹

2016

IJNFS

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Abstract:This study was performed to investigate the effect of halawa tahinia alone or in combination with ginger and cinnamon on sex hormones as well as serum antioxidant levels. Thirty Wistar adult male rat were divided into five groups, control group fed on basal diet only and test groups (n=24) divided into 4 groups as follow, group (1) fed on basal diet supplemented with halawa tahinia at the level of (15%), while the other three groups were fed on basal diet supplemented with halawa tahinia (15%) and were given orally (500 mg/kg/day) dried ginger, (500 mg/kg/day) dried cinnamon, both dried ginger and cinnamon (500 mg/kg/day) respectively for 8 weeks. The results indicated that, halawa tahinia have a high nutritive value. The obtained results revealed also that, oral administration of ginger and/ or cinnamon with halawa tahinia caused a significant (p<0.05) protective effects on testes due to increasing the levels of serum total testosterones, follicular stimulating hormone (FSH) and luteinizing hormone (LH) also increasing serum total antioxidants capacity (TAC) levels with decreasing malondialdehyde (MDA) level as well as have no deleterious effects on liver functions as compared to control group. Moreover, both ginger and cinnamon administration has a synergistic effect on infertility due to their antioxidant properties. In conclusion: These results provide scientific evidence to substantiate the traditional use of cinnamon and ginger as a drink as well as Halawa tahinia in improving infertility in male rats which might be a product for their potent antioxidant properties and androgenic activities.

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Antioxidative activity of the crude extract of lignan glycosides from unroasted Burma black sesame meal

Cited by 182 publications

References 18 publications

Antioxidant activity in selected Slovenian organic and conventional crops

Antioxidant activity in selected Slovenian organic and conventional crops

Sesaminol Glucosides Protect .BETA.-Amyloid Peptide-Induced Cognitive Deficits in Mice

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

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