Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice

Chen, Chiu-Mei; Yin, Mei‐chin; Hsu, Cheng‐Chin; Liu, Ting-chun

doi:10.1016/j.nut.2007.05.004

Cited by 50 publications

(39 citation statements)

References 29 publications

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“…It is reasonable to suspect that an age-related decline in brain glutathione and Nrf2 could exacerbate their progression. Indeed, NAC has shown efficacy in rodent models of these disorders (Offen et al 1996;Martinez 2000;Chen et al 2007;Clark et al 2010;Berman et al 2011;Martinez-Banaclocha 2012;Smeyne and Smeyne 2013;Moreira et al 2007;Huang et al 2010;Pocernich and Butterfield 2012;Hsiao et al 2012;Farr et al 2003). NAC is also beneficial in a mouse model of ALS (Andreassen et al 2000).…”

Section: Supplemental Nac In Aging Humans and Rodents Provides Versatmentioning

confidence: 99%

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

McCarty

DiNicolantonio

2015

AGE

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Restricted dietary intakes of protein or essential amino acids tend to slow aging and boost lifespan in rodents, presumably because they downregulate IGF-I/ Akt/mTORC1 signaling that acts as a pacesetter for aging and promotes cancer induction. A recent analysis of the National Health and Nutrition Examination Survey (NHANES) III cohort has revealed that relatively low protein intakes in mid-life (under 10 % of calories) are indeed associated with decreased subsequent risk for mortality. However, in those over 65 at baseline, such low protein intakes were associated with increased risk for mortality. This finding accords well with other epidemiology correlating relatively high protein intakes with lower risk for loss of lean mass and bone density in the elderly.

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Section: Supplemental Nac In Aging Humans and Rodents Provides Versatmentioning

confidence: 99%

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

McCarty

DiNicolantonio

2015

AGE

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“…Several animal models of PD have shown that NAC ameliorates dopaminergic neuronal loss [10e15]. NAC administered to MPTPtreated mice showed restoration of dopamine, GSH, total tissue thiol levels and glutathione peroxidase activity in the SNc [12,14,15]. NAC has also been shown to increase GSH within the substantia nigra, decrease the loss of dopaminergic terminals, and reduce the accumulation of a-synuclein in the striatum in transgenic mice overexpressing wild-type human a-synuclein [13].…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease

Katz

Won

Park

et al. 2015

Parkinsonism & Related Disorders

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a b s t r a c tIntroduction: Depletion of neuronal glutathione may contribute to the pathogenesis of Parkinson's disease (PD). N-acetylcysteine (NAC) can restore neuronal glutathione levels, but it has not been established whether NAC can cross the bloodebrain barrier in humans. Methods: Twelve patients with PD were given oral NAC twice daily for 2 days. Three doses were compared: 7 mg/kg, 35 mg/kg, and 70 mg/kg. NAC, cysteine, and glutathione were measured in the cerebrospinal fluid (CSF) at baseline and 90 min after the last dose. Cognitive and motor functions were assessed pre-and post-NAC administration using the Montreal Cognitive Assessment (MoCA) and the Unified Parkinson's Disease Rating Scale part III motor subscore (UPDRS-III). Results: Oral NAC produced a dose-dependent increase in CSF NAC concentrations (p < 0.001), with the highest dose producing a CSF concentration of 9.26 ± 1.62 mM. There were no significant adverse events.NAC had no acute effect on motor or cognitive function. Conclusion: Orally administered NAC produces biologically relevant CSF NAC concentrations at doses that are well tolerated. The findings support the feasibility of NAC as a potential disease-modifying therapy for PD.

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“…There is a strong need to develop preventive strategies for neurodegenerative diseases in those with genetic predisposition. However, despite promising results with dietary phytonutrient supplements in rodent models that are genetically susceptible to develop Alzheimer or Parkinson’s disease [44,45,46,47,48], the knowledge base for humans is currently insufficient to make genotype-specific recommendations. …”

Section: Nutrigenetics and Nutrigenomics In Optimising Well-being Andmentioning

confidence: 99%

Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice

et al. 2011

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Nutrigenetics and nutrigenomics hold much promise for providing better nutritional advice to the public generally, genetic subgroups and individuals. Because nutrigenetics and nutrigenomics require a deep understanding of nutrition, genetics and biochemistry and ever new ‘omic’ technologies, it is often difficult, even for educated professionals, to appreciate their relevance to the practice of preventive approaches for optimising health, delaying onset of disease and diminishing its severity. This review discusses (i) the basic concepts, technical terms and technology involved in nutrigenetics and nutrigenomics; (ii) how this emerging knowledge can be applied to optimise health, prevent and treat diseases; (iii) how to read, understand and interpret nutrigenetic and nutrigenomic research results, and (iv) how this knowledge may potentially transform nutrition and dietetic practice, and the implications of such a transformation. This is in effect an up-to-date overview of the various aspects of nutrigenetics and nutrigenomics relevant to health practitioners who are seeking a better understanding of this new frontier in nutrition research and its potential application to dietetic practice.

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Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice

Cited by 50 publications

References 29 publications

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease

Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice

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