Antioxidative and Hepatoprotective Diarylheptanoids from the Bark of<i>Alnus japonica</i>

Tung, Nguyen Hưu; Kim, Sang Kyum; Chan, Jeong; Zhao, Yongfeng; Sohn, Dong Hwan; Kim, Young Ho

doi:10.1055/s-0029-1240595

Cited by 47 publications

(32 citation statements)

References 14 publications

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“…These compounds are characteristic for Zingiber, Curcuma, Alpinia, Betula, and Alnus. They exhibit antioxidative (Matsuda et al 1998;Tung et al 2010a), anti-inflammatory (Lai et al 2012), antiviral (Tung et al 2010b), cytotoxic (Mshvildadze et al 2007;Choi et al 2008;Liu et al 2008;Sun et al 2008), and anticancer activities (Mshvildadze et al 2007;Choi et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the diarylheptanoids from the black and green alder

Novaković

Cvetković

et al. 2015

Braz. J. Bot

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Antimicrobial activity of fourteen diarylheptanoids isolated from the bark of black and green alder against twelve bacterial species (five Gram-positive and seven Gram-negative) and eight fungal strains has been reported. The most sensitive bacterial species were Klebsiella pneumoniae and Pseudomonas aeruginosa (Gramnegative), and Streptosporangium longisporum and Bacillus subtilis (Gram-positive). Among fungal strains the most sensitive to the diarylheptanoids were Fusarium equiseti, F. tricinctum, Candida albicans, and Saccharomyces cerevisiae. Oregonin (8), platyphyllenone (13), hirsutenone (14), (5S)-5-hydroxy-1,7-bis(4-hydroxyphenyl)heptan-3-one-5-O-b-D-apiofuranosyl(1 ? 6)-b-D-glucopyranoside (2), and platyphylloside (1) were the most active diarylheptanoids against both bacteria and fungi, especially against fungi. Eleven of fourteen investigated diarylheptanoids exhibited stronger antifungal activity than standards nystatin and fluconazole against C. albicans and eight against S. cerevisiae. Structure/activity analysis revealed the importance of the enone moiety in the structure of diarylheptanoids for the antifungal activity. Significant antifungal activity and high content of oregonin (8) and hirsutenone (14) in the black alder bark chloroform/ methanol (1:1) extract recommend the use of these compounds as easily accessible potential antifungal remedies.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the diarylheptanoids from the black and green alder

Novaković

Cvetković

et al. 2015

Braz. J. Bot

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“…It has been used in traditional oriental medicine to treat fever, hemorrhage, diarrhea, and alcoholism. Recent studies have shown that Alnus japonica has various phytochemicals, such as diarylheptanoids, triterpenoids, and flavonoids91011121314. In this study, we isolated a lignan [(−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS] from Alnus japonica and explored its activity against colon cancer.…”

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confidence: 99%

A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocation

Dong

Jeong

Lee

et al. 2017

Sci Rep

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Colon cancer is one of the most common cancers. In this study, we isolated a lignan [(−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS] from Alnus japonica (Betulaceae) and investigated its biological activity and mechanism of action on colon cancer. DFS reduced the viability of colon cancer cells and induced cell cycle arrest. DFS also suppressed β-catenin nuclear translocation and β-catenin target gene expression through a reduction in FoxM1 protein. To assess the mechanism of the action of DFS, we investigated the effect of DFS on endogenous and exogenous FoxM1 protein degradation in colon cancer cells. DFS-induced FoxM1 protein degradation was suppressed by lysosomal inhibitors, chloroquine and bafilomycin A1, but not by knock-down of proteasomal proteins. The mechanism of DFS for FoxM1 degradation is lysosomal dependent, which was not reported before. Furthermore, we found that FoxM1 degradation was partially lysosomal-dependent under normal conditions. These observations indicate that DFS from A. japonica suppresses colon cancer cell proliferation by reducing β-catenin nuclear translocation. DFS induces lysosomal-dependent FoxM1 protein degradation. This is the first report on the lysosomal degradation of FoxM1 by a small molecule. DFS may be useful in treating cancers that feature the elevated expression of FoxM1.

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“…Chemical constituents of A. japonica have been reported including numerous diarylheptanoids, along with several triterpenoids, and flavonoids [2][3][4][5]. Our previous study also led to the identification of many diarylheptanoids from the bark of A. japonica, and some of which exhibited antioxidant and antiviral activities [6,7]. In our ongoing study on phytochemical components from this plant, three diarylheptanoids (1-3), including a new one, namely epihirsutanonol, were isolated from the bark (Figure 1).…”

Section: Introductionmentioning

confidence: 97%