Antioxidative, anti-inflammatory and anti-apoptotic action of ellagic acid against lead acetate induced testicular and hepato-renal oxidative damages and pathophysiological changes in male Long Evans rats

Bidanchi, Rema Momin; Lalrindika, Lalrinsanga; Khushboo, Maurya; Bhanushree, Baishya; Dinata, Roy; Das, Milirani; Nisa, Nisekhoto; Lalrinzuali, Sailo; Manikandan, Bose; Saeed-Ahmed, Laskar; Sanjeev, Sanasam; Murthy, Meesala Krishna; Roy, Vikas Kumar; Gurusubramanian, Guruswami

doi:10.1016/j.envpol.2022.119048

Cited by 36 publications

(12 citation statements)

References 89 publications

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“…Glycosyldeoxycholic acid (GUDCA) is considered to have antiapoptotic, antioxidant, and anti-inflammatory properties [ 23 ]. It has been found that GUDCA could reduce the production of lactate dehydrogenase, TNF- α , and IL-1 β in the nervous system and reduce the production of cytochrome C peroxidase in neurodegenerative models [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS

Zhou

Luo

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Stable angina pectoris (SAP) is one of the main types of coronary heart disease (CHD). To improve treatment outcomes, more effective biomarkers are needed. Currently, studies on the metabolic characteristics of SAP are lacking. Here, we explored the serum metabolomic profile of SAP and identified potential biomarkers and related pathways to assist the clinical diagnosis and treatment of SAP. Method. Thirty patients with SAP patients and 30 healthy controls (CON) without stenosis were selected for this study. All patients underwent coronary angiography. The metabolites of the two groups’ serum samples were investigated using UHPLC-QE-MS. Changes in serum metabolic profile were evaluated using multivariate statistical analysis and pathway analysis. Result. OPLS-DA analysis identified significant differences in the serum metabolic profiles between patients with SAP and CON. Twenty-five differential metabolites were identified between patients from SAP and CON groups, including choline, creatine, L-arginine, beta-guanidinopropionic acid, isopalmitic acid, xanthine, LysoPC (18 : 1), and LysoPC (20 : 3). Pathway analysis found that these differential metabolites were involved in energy metabolism, oxidative stress, purine metabolism, and other metabolic pathways. Conclusion. By comparing the serum metabolic profiles of SAP patients with a control group, we identified 25 potential biomarkers that could improve the clinical diagnosis and treatment of SAP.

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Section: Discussionmentioning

confidence: 99%

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS

Zhou

Luo

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Several studies have reported that GB exhibits antioxidant [ 53 , 54 , 55 ] and anti-inflammatory [ 56 , 57 ] activities. GB administration decreased homocysteine levels [ 57 , 58 ] in several organisms and increased S-adenosyl methionine and glutathione contents, with high antioxidant activity [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, GB administration was found to reduce the accumulation of fats in the liver caused by ethanol consumption [ 53 , 56 ] and high-calorie diets [ 61 ]. Moreover, GB treatment was suggested to exert reductive effects on hepatic dysfunction and fibrosis induced by ethanol and carbon tetrachloride [ 57 ] and dimethylnitrosamine [ 59 ] in rats and by carbon tetrachloride in chicken [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Glycine Betaine Relieves Lead-Induced Hepatic and Renal Toxicity in Albino Rats

Abdelrazek

Salama

Alharthi

et al. 2022

Toxics

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Lead (Pb) is a widespread and nondegradable environmental pollutant and affects several organs through oxidative mechanisms. This study was conducted to investigate the antioxidant protective effect of glycine betaine (GB) against Pb-induced renal and hepatic injury. Male albino rats (n = 45) were divided into three groups: G1 untreated control, G2 Pb-acetate (50 mg/kg/day), and G3 Pb-acetate (50 mg/kg/day) plus GB (250 mg/kg/day) administered for 6 weeks. For G3, Pb-acetate was administered first and followed by GB at least 4 h after. Pb-acetate treatment (G2) resulted in a significant decrease in renal function, including elevated creatinine and urea levels by 17.4% and 23.7%, respectively, and nonsignificant changes in serum uric acid levels. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphates (ALP) activities were significantly increased with Pb treatment by 37.6%, 59.3%, and 55.1%, respectively. Lipid peroxidation level was significantly increased by 7.8 times after 6 weeks of Pb-acetate treatment. The level of reduced glutathione (GSH-R) significantly declined after Pb-acetate treatment. Pb-acetate treatment also reduced the activities of superoxide dismutase (SOD), glutathione-S-transferase (GST), and glutathione peroxidase (GSH-PX) by 74.1%, 85.0%, and 40.8%, respectively. Treatment of Pb-intoxicated rats with GB resulted in a significant reduction in creatinine, urea, ALT, AST, and lipid peroxidation, as well as a significant increase in the level of GSH-R and in the activities of ALP, SOD, GST, and GSH-PX. The molecular interaction between GB and GSH-PX indicated that the activation of GSH-PX in Pb-intoxicated rats was not the result of GB binding to the catalytic site of GSH-PX. The affinity of GB to bind to the catalytic site of GSH-PX is lower than that of H2O2. Thus, GB significantly mitigates Pb-induced renal and liver injury through the activation of antioxidant enzymes and the prevention of Pb-induced oxidative damage in the kidney and liver.

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“…As we known, drug metabolism in the body is a complex progress. DWPE produced extensive metabolic reactions in rats and the absorbed compounds in vivo were mainly the metabolites of glansreginin A (Gla A), gallic acid (GA), and ellagic acid (EA), which were the effective components of DWPE in vivo (Bidanchi et al, 2022;Haramiishi et al, 2020;Tošović & Bren,…”

Section: Introductionmentioning

confidence: 99%

Effect of defatted walnut powder extract on pigment gallstones and its metabolism in vitro

FANG

et al. 2023

Food Sci. Technol

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Gallstones disease is classified as cholesterol, pigment and mixed gallstones. Pigment gallstones is a common disease, and some patients experienced complications such as biliary pain and cholecystitis. Defatted walnut powder extract (DWPE) is extracted from the main by-product after oil extraction of the functional food walnut and can treat cholesterol gallstones. However, the effect of DWPE on pigment gallstones has not been reported. Thus, this paper aimed at exploring the potential mechanism of alleviating pigment gallstones and the metabolism of DWPE in vitro by UPLC-Q-Exactive Orbitrap MS to elucidate potential pharmacodynamic substances. It was found that DWPE significantly reduced the incidence of gallstones, the contents of unconjugated bilirubin and calcium, the inflammation of gallbladder tissue, the edema and congestion of gallbladder tissue, and the infiltration of inflammatory cells. In metabolism, a total of 35 metabolites of DWPE, including its main compounds ellagic acid and glansreginin A, were characterized in the intestine with various metabolic reactions. Presumably, the small molecular compounds generated after the metabolism by intestinal bacteria may be the pharmacodynamic substances of DWPE on pigment gallstones. This study revealed the effect of DWPE in treating pigment gallstones and their metabolism in vitro.

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Antioxidative, anti-inflammatory and anti-apoptotic action of ellagic acid against lead acetate induced testicular and hepato-renal oxidative damages and pathophysiological changes in male Long Evans rats

Cited by 36 publications

References 89 publications

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS

Glycine Betaine Relieves Lead-Induced Hepatic and Renal Toxicity in Albino Rats

Effect of defatted walnut powder extract on pigment gallstones and its metabolism in vitro

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