2020
DOI: 10.1016/j.heliyon.2020.e05743
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Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

Abstract: Oxidative stress, chronic inflammation, dyslipidemia, hyperglycemia, and shear stress (physical effect) are risk factors associated with the pathogenesis of atherosclerosis. Rice bran, a by-product of rice milling process, is known to house polyphenols and vitamins which exhibit potent antioxidant and anti-inflammatory properties. Through recent emerging knowledge of rice bran in health and wellness, the present study was aimed to assess the ameliorative effects of rice bran extracts (RBE) derived from Japanes… Show more

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Cited by 12 publications
(15 citation statements)
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“…According to different pigmentation types of the outer layer, whole grain rice can be classified as black, green, red, etc. Pigmented rice is also becoming more popular due to its beneficial cardiovascular effects against atherosclerosis and hypertension, mainly due to its antioxidant properties ( Jan-On et al, 2020 ; Tan et al, 2020 ). However, comparing the antioxidant properties of different pigmented RBEs, including their vasorelaxant effects and underlying mechanisms, remains unclear ( Jun et al, 2012 ).…”
Section: Discussionmentioning
confidence: 99%
“…According to different pigmentation types of the outer layer, whole grain rice can be classified as black, green, red, etc. Pigmented rice is also becoming more popular due to its beneficial cardiovascular effects against atherosclerosis and hypertension, mainly due to its antioxidant properties ( Jan-On et al, 2020 ; Tan et al, 2020 ). However, comparing the antioxidant properties of different pigmented RBEs, including their vasorelaxant effects and underlying mechanisms, remains unclear ( Jun et al, 2012 ).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the mechanisms involved in white adipose tissue (WAT) dysfunction could represent a potential therapeutic target for the treatment of obesity-associated disorders. Red rice (Oryza sativa L.) and its bran are abundant sources of bioactive compounds, such as phenolic compounds, flavonoids, anthocyanins, proanthocyanidins, protocatechuic acid, ferulic acid, γ-oryzanol, and vitamin E [10][11][12][13][14]. Red rice bran extract (RRBE) has been reported to show various beneficial properties, including antioxidant [10], metabolic [11], and anti-inflammatory activities [12,15], which may occur due to the presence and combination of phenolic compounds, such as anthocyanins and proanthocyanidins.…”
Section: Introductionmentioning
confidence: 99%
“…Red rice (Oryza sativa L.) and its bran are abundant sources of bioactive compounds, such as phenolic compounds, flavonoids, anthocyanins, proanthocyanidins, protocatechuic acid, ferulic acid, γ-oryzanol, and vitamin E [10][11][12][13][14]. Red rice bran extract (RRBE) has been reported to show various beneficial properties, including antioxidant [10], metabolic [11], and anti-inflammatory activities [12,15], which may occur due to the presence and combination of phenolic compounds, such as anthocyanins and proanthocyanidins. A previous study using in vitro chemical-based assays has shown that RRBE from the Hawm or Hawm Dowk Mali Deang variety exhibits the highest phenolic content and antioxidant activities in comparison with the extracts from other colored rice varieties [10].…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, red rice bran showed the highest effectiveness on the antidiabetic activity among pigmented rice [ 24 ]. Interestingly, rice bran extracts the ameliorative effects of atherosclerosis in high-fat diet (HFD)-induced mice by lowering cholesterol, triglycerides, and oxidized LDL [ 27 ]. In addition, the anti-inflammatory activity of proanthocyanidin from red rice extract decreased the production of TNF-α and IL-6 by downregulating the expression of activator proteins-1 (AP-1) and nuclear factor kappa B (NF-Κb) pathways in LPS-stimulated RAW264.7 macrophage cells [ 28 ].…”
Section: Introductionmentioning
confidence: 99%