Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial

Seo, Seok Kyo; Hong, Yeon Hee; Yun, Bo Hyon; Chon, Seung Joo; Jung, Yeon Soo; Park, Joo Hyun; Cho, SiHyun; Choi, Young Sik; Lee, Byung Seok

doi:10.1016/j.jep.2014.04.051

Cited by 47 publications

(59 citation statements)

References 25 publications

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“…Studies have shown that ginseng has a number of biological activities, including as an antioxidant, anti-aging agent, inhibitor of cell apoptosis and cognition enhancer (10,11). Ginsenosides are active compounds extracted from ginseng, and it has been demonstrated that ginsenoside Rg1 is able to improve memory and has anti-dementia effects (12).…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Guo

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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The aim of the present study was to investigate the effect of ginsenoside compound K on β-amyloid (Aβ) peptide clearance in primary astrocytes. Aβ degradation in primary astrocytes was determined using an intracellular Aβ clearance assay. Aggregated LC3 in astrocyte cells, which is a marker for the level of autophagy, was detected using laser scanning confocal microscope. The effect of compound K on the mammalian target of rapamycin (mTOR)/autophagy pathway was determined using western blot analysis, and an enzyme-linked immunosorbent assay was used for Aβ detection. The results demonstrated that compound K promoted the clearance of Aβ and enhanced autophagy in primary astrocytes. In addition, it was found that phosphorylation of mTOR was inhibited by compound K, which may have contributed to the enhanced autophagy. In conclusion, compound K promotes Aβ clearance by enhancing autophagy via the mTOR signaling pathway in primary astrocytes.

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Section: Introductionmentioning

confidence: 99%

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Guo

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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“…Examples of excluded studies were those that administered ginseng with additional compounds including konjac root‐based fiber blend, mulberry, and persimmon vinegar. In total, eight studies met all inclusion criteria and were included in meta‐analyses (Ahn et al, , Delui et al, , Hong et al, , Hosseini et al, , Jung et al, , Kim, Seo, et al, , Park et al, , Seo et al, ).…”

Section: Resultsmentioning

confidence: 99%

Effects of ginseng supplementation on selected markers of inflammation: A systematic review and meta‐analysis

Mohammadi

Hadi

Kord‐Varkaneh

et al. 2019

Phytotherapy Research

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The present meta-analysis was performed to evaluate the efficacy of ginseng administration on serum level of inflammatory biomarkers. We performed a systematic search of all available randomized controlled trials (RCTs) conducted up to June 2018 in the following electronic databases: PubMed, Scopus, Cochrane, and Google Scholar. RCTs that investigated the effect ginseng supplementation on highsensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were included for final analysis. A total of seven RCTs were included in the meta-analysis. Results indicated significant reduction in IL-6 (mean difference [MD]: −0.265 pg/ml, 95% CI [−0.396, −0.135], p < .001) and TNF-α (MD: −2.471 pg/ml, 95% CI [−2.904, −2.039], p < .001) and no significant change in hs-CRP (MD: −0.125 mg/L, 95% CI [−0.597, 0.347], p = .604). Although there waspublication bias across studies, trim and fill analysis showed that results from unpublished studies could not change the results for CRP. However, removing one study in sensitivity analysis did reveal a significant reduction in CRP. We conclude that ginseng supplementation significantly lowered IL-6 and TNF-α but did not significantly lower CRP. However, these findings were not robust, because they showed sensitivity for CRP and IL-6, and future long-term well-designed dose-escalating trials are required.

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“…Thus, The North American Menopause Society recommended black cohosh for the treatment of women with menopausal symptoms [21]. A 2011-2012 randomized, double-blind, placebo-controlled clinical trial conducted on 84 early post-menopausal participants with Greene climacteric scale (GCS) scores of 15 to 42 showed that black cohosh extract reduced the total and subscale scores (vasomotor, psychiatric, physical, and sexual symptoms) during the 4-8 w of treatment [22][23][24][25]. Some studies found that chemicals in black cohosh extract do not bind to ERs in ligand binding assays with recombinant estrogen receptors [26].…”

Section: Resultsmentioning

confidence: 99%

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

Basu

Sunny

Maier

2016

Int J Pharm Pharm Sci

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Objective: This study aimed to assess the estrogenic and antiestrogenic activities of five dietary supplements, commercially available for treatment of menopausal symptoms, before and after gastrointestinal digestion by employing a yeast steroid-regulated transcription system. Methods: Supplements (S) were extracted with either 80% methanol or water. Water extracts were subjected to simulated gastrointestinal (GI) digestion. Estrogenic and antiestrogenic activities were assessed by a steroid-regulated transcription system in Saccharomyces cerevisiae expressing the human estrogen receptor alpha. Results:The highest estrogenic activities were detected in both S1 methanol (2342.5±20.83 MU) and water (1225.6±20.6 MU) extracts (400 estradiol equivalents). Extracts showed antiestrogenic properties by reducing the transcriptional activity induced by estradiol in transgenic yeast. The highest antiestrogenic activity was detected in S2 methanol extract and S3 water extract, which inhibited estradiol activity by 76% and 64%, respectively. After GI digestion, S1, S2 and S3 extracts showed significantly higher estrogenic and antiestrogenic activities as 'serum-available' than 'colon-available' samples and S4 and S5 extracts showed significantly higher activities as 'colon-available' than 'serum-available' samples. Conclusion:All dietary supplements revealed estrogenic and antiestrogenic activities. The GI digestion demonstrated the availability of phytoestrogens for absorption in the blood stream. Supplements containing soy isoflavones and alfalfa ingredients had the highest estrogenic activities and could be more effective than supplements with complex plant formulation in alleviating menopausal symptoms and treating osteoporosis. The transgenic yeast assays proved to be a powerful tool for assessing the in vitro estrogenic and antiestrogenic activities of dietary supplements.

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Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial

Cited by 47 publications

References 25 publications

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Effects of ginseng supplementation on selected markers of inflammation: A systematic review and meta‐analysis

Estrogenic and Antiestrogenic Activities of Commercial Dietary Supplements Containing Herbal Ingredients and Isoflavones

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