Antioxidative enzymes and increased oxidative stress in depressive women

Kodydková, Jana; Vávřová, Lucie; Zeman, Miroslav; Jirák, Roman; Macášek, Jaroslav; Staňková, Barbora; Tvrzická, E; A, Žák

doi:10.1016/j.clinbiochem.2009.06.006

Cited by 171 publications

(104 citation statements)

References 46 publications

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“…For example, decreased red blood cell (RBC) SOD activity was reported in patients diagnosed with recurrent depressive disorder (Rybka et al, 2013), lowered serum SOD levels in patients with major depression (Herken et al, 2007, Stefanescu andCiobica, 2012), and even greater reductions in serum SOD in patients with recurrent depression, compared to a first episode group (Stefanescu and Ciobica, 2012). However, in other studies increased RBC SOD in depressed patients were found (Bilici et al, 2001, Galecki et al, 2009a, Kodydkova et al, 2009, Kotan et al, 2011, Sarandol et al, 2007, and serum SOD was positively associated with increasing severity of depression (Khanzode et al, 2003). Reasons for these inconsistent findings are not clear, although may be related to variable collection protocols, analysis methods and whether RBC or serum was analysed (e.g., RBC levels were elevated in four out of five studies reviewed, while serum levels were lower in two out of three studies reviewed).…”

Section: Accepted M Manuscriptmentioning

confidence: 85%

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A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

312

180

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Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.

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Section: Accepted M Manuscriptmentioning

confidence: 85%

“…Levels of RBC glutathione peroxidase (GPx) have been most commonly evaluated in depressed populations with decreases (Kodydkova et al, 2009, Rybka et al, 2013, increases (Bilici et al, 2001), and no differences (Galecki et al, 2009a) found between depressed and healthy control groups.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

312

180

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“…Since the activity of GLR maintains a high ratio of reduced to oxidized glutathione (GSH/GSSG), our results of a decreased GLR/GPx ratio suggest shifting the GSH balance to the oxidative form (GSSG) and diminished capacity of GPx for antioxidative defence, which could lead to oxidative stress in lymphocytes of depressed patents. Indeed, reduced levels of GSH are reported in depressed patients as well as in other psychiatric disorders [1,31]. …”

Section: Discussionmentioning

confidence: 99%

“…Likewise, CAT activity was found to be unchanged [25,30] or increased [28,29] in MDD patients. Concerning enzymes involved in GSH metabolism, it was shown that GPx activity was decreased [31,32,33] or unchanged [25,28,30], while GSH levels were reported to be reduced [31] in the blood of MDD patients compared to healthy subjects. This data inconsistency with regard to AOEs in MDD could be a consequence of methodological approach, since the data reflect AOE activities in serum, plasma, red blood cells or leucocytes of patients with different stages of illness and thus they rather indicate systematic changes in redox state in the peripheral blood of these patients.…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients

Lukić¹,

Mitić²,

Djordjević³

et al. 2014

Neuropsychobiology

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Background: Oxidative stress is reliably observed in major depressive disorder (MDD). However, molecular data on the principal cellular redox-sensitive transcriptional factors and the levels of their downstream-regulated antioxidant enzymes in MDD are scarce. Methods: In the peripheral blood mononuclear cells (PBMC) of subjects with a current episode of MDD (n = 30) and healthy controls (n = 35), we investigated alterations in the levels of redox-sensing nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein, its inhibitor Keap1, and nuclear factor-κB (NF-κB), along with their cognate downstream effectors, the antioxidant enzymes (AOEs): manganese and copper zinc superoxide dismutase (MnSOD and CuZnSOD, respectively), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR). Results: MDD subjects exhibited higher levels of Nrf2 and its regulator Keap1, as well as NF-κB in the cytoplasm of PBMC compared to controls. This state was further reflected by increased levels of MnSOD, CuZnSOD and CAT proteins and by the lack of correlation between MnSOD and CAT, which could indicate impaired oxidative detoxification capacity in MDD patients. Moreover, increased levels of MnSOD, CuZnSOD and CAT in MDD patients positively correlated with levels of Nrf2, while increased levels of SODs were also positively related to NF-κB. There were no differences regarding the levels of GPx and GLR proteins, but the ratio of GLR/GPx was reduced, suggesting diminished capacity of GPx in antioxidative defence in PBMC of MDD subjects. Conclusion: These data provide evidence that MDD is characterized by up-regulation of redox-sensitive transcriptional factors (Nrf2 and NF-κB) and AOEs (MnSOD, CuZnSOD and CAT), indicating pro-oxidative state in the PBMC of MDD patients.

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“…The ox-LDL measurement was performed using an oxidized LDL ELISA kit (Mercodia, Uppsala, Sweden). Activities of antioxidant enzymes were determined by spectrophotometric kinetic methods as previously described [19], and concentration of CD/LDL was measured according to Ahotupa et al [20]. The concentration of nitrotyrosine was measured using a solid-phase sandwich ELISA kit (Biovendor, Brno, Czech Republic).…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Increased inflammatory markers with altered antioxidant status persist after clinical recovery from severe sepsis: a correlation with low HDL cholesterol and albumin

et al. 2015

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Markers of oxidative stress and antioxidant status in relation to inflammatory mediators in septic patients (SPs) during the course of sepsis and after recovery were analysed. Patients were 30 critically ill adults in severe sepsis/septic shock, 19 of which completed 3 samplings (S1: within 24 h after onset of sepsis, S7: 7 days after S1, R7: 7 days after clinical recovery). Comparing SPs with healthy controls (HCs), enhanced C-reactive protein, procalcitonin, bilirubin and CuZn-superoxide dismutase activity were found at S1 only. Oxidized low-density lipoprotein, conjugated dienes and nitrotyrosine were increased at S1, culminated at S7 and reverted nearly to HC levels at R7. Reduced catalase activity and serum amyloid were observed at S1 and endured until R7. Increase in IL-6, IL-10 and tumour necrosis factor alpha (TNF-α) with accompanying decrease in apolipoprotein A1, high-density lipoprotein (HDL) cholesterol, selenium, zinc, albumin, paraoxonase 1 and glutathione peroxidase 1 activity appeared at S1 and persisted until R7. TNF-α, IL-10 and markers of oxidative stress were in negative correlation with HDL cholesterol and albumin at R7. After clinical recovery, increased cytokines and decreased antioxidants were accompanied by lower albumin and HDL cholesterol levels. During this important and beneficial period of tissue repair, patients with prolonged persistence of this status are probably more vulnerable to secondary infections and should be dealt with as constituting a high-risk population.

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Antioxidative enzymes and increased oxidative stress in depressive women

Cited by 171 publications

References 46 publications

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lymphocyte Levels of Redox-Sensitive Transcription Factors and Antioxidative Enzymes as Indicators of Pro-Oxidative State in Depressive Patients

Increased inflammatory markers with altered antioxidant status persist after clinical recovery from severe sepsis: a correlation with low HDL cholesterol and albumin

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